| Full name: complement C1q C chain | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.12 | ||
| Entrez ID: 714 | HGNC ID: HGNC:1245 | Ensembl Gene: ENSG00000159189 | OMIM ID: 120575 |
| Drug and gene relationship at DGIdb | |||
C1QC involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades | |
| hsa05133 | Pertussis | |
| hsa05142 | Chagas disease (American trypanosomiasis) | |
| hsa05150 | Staphylococcus aureus infection |
Expression of C1QC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | C1QC | 714 | 225353_s_at | 0.2762 | 0.8123 | |
| GSE26886 | C1QC | 714 | 225353_s_at | -0.0852 | 0.8131 | |
| GSE45670 | C1QC | 714 | 225353_s_at | -0.0016 | 0.9977 | |
| GSE53622 | C1QC | 714 | 4158 | 0.7558 | 0.0000 | |
| GSE53624 | C1QC | 714 | 4158 | 0.4866 | 0.0000 | |
| GSE63941 | C1QC | 714 | 225353_s_at | 0.0092 | 0.9509 | |
| GSE77861 | C1QC | 714 | 225353_s_at | 0.4681 | 0.2371 | |
| GSE97050 | C1QC | 714 | A_23_P125977 | 0.9955 | 0.1514 | |
| SRP007169 | C1QC | 714 | RNAseq | 1.7191 | 0.0091 | |
| SRP008496 | C1QC | 714 | RNAseq | 1.4575 | 0.0004 | |
| SRP064894 | C1QC | 714 | RNAseq | 1.1996 | 0.0028 | |
| SRP133303 | C1QC | 714 | RNAseq | 1.0541 | 0.0042 | |
| SRP159526 | C1QC | 714 | RNAseq | 0.6493 | 0.3252 | |
| SRP193095 | C1QC | 714 | RNAseq | 0.7823 | 0.0015 | |
| SRP219564 | C1QC | 714 | RNAseq | 2.1498 | 0.0134 | |
| TCGA | C1QC | 714 | RNAseq | 0.3632 | 0.0029 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by C1QC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of C1QC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | C1QC | 714 | 0 | 5 | 25 | |
| GSE20123 | C1QC | 714 | 0 | 4 | 26 | |
| GSE43470 | C1QC | 714 | 2 | 6 | 35 | |
| GSE46452 | C1QC | 714 | 5 | 1 | 53 | |
| GSE47630 | C1QC | 714 | 8 | 3 | 29 | |
| GSE54993 | C1QC | 714 | 2 | 1 | 67 | |
| GSE54994 | C1QC | 714 | 11 | 4 | 38 | |
| GSE60625 | C1QC | 714 | 0 | 0 | 11 | |
| GSE74703 | C1QC | 714 | 1 | 4 | 31 | |
| GSE74704 | C1QC | 714 | 0 | 0 | 20 | |
| TCGA | C1QC | 714 | 10 | 23 | 63 |
Total number of gains: 39; Total number of losses: 51; Total Number of normals: 398.
Somatic mutations of C1QC:
Generating mutation plots.
Highly correlated genes for C1QC:
Showing top 20/456 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| C1QC | C1QB | 0.870103 | 8 | 0 | 8 |
| C1QC | C1QA | 0.844862 | 8 | 0 | 8 |
| C1QC | FCER1G | 0.833155 | 7 | 0 | 7 |
| C1QC | TYROBP | 0.831917 | 8 | 0 | 8 |
| C1QC | ITGB2 | 0.7821 | 7 | 0 | 7 |
| C1QC | AIF1 | 0.780979 | 8 | 0 | 8 |
| C1QC | LAPTM5 | 0.777166 | 8 | 0 | 8 |
| C1QC | FCGR3A | 0.757256 | 3 | 0 | 3 |
| C1QC | MS4A6A | 0.756527 | 7 | 0 | 7 |
| C1QC | FPR3 | 0.752928 | 7 | 0 | 6 |
| C1QC | CD14 | 0.74395 | 8 | 0 | 8 |
| C1QC | TFEC | 0.740906 | 6 | 0 | 5 |
| C1QC | PLXNC1 | 0.739032 | 5 | 0 | 5 |
| C1QC | CSF1R | 0.734916 | 8 | 0 | 8 |
| C1QC | CD53 | 0.72721 | 6 | 0 | 6 |
| C1QC | SIGLEC1 | 0.726902 | 6 | 0 | 6 |
| C1QC | PDCD1LG2 | 0.726395 | 3 | 0 | 3 |
| C1QC | C3AR1 | 0.724752 | 7 | 0 | 5 |
| C1QC | TMEM140 | 0.724131 | 6 | 0 | 6 |
| C1QC | LAIR1 | 0.723369 | 5 | 0 | 5 |
For details and further investigation, click here
