| Full name: complement C5a receptor 1 | Alias Symbol: C5A|C5AR|CD88 | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 728 | HGNC ID: HGNC:1338 | Ensembl Gene: ENSG00000197405 | OMIM ID: 113995 |
| Drug and gene relationship at DGIdb | |||
C5AR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05150 | Staphylococcus aureus infection |
Expression of C5AR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | C5AR1 | 728 | 220088_at | 0.6737 | 0.4067 | |
| GSE20347 | C5AR1 | 728 | 220088_at | 0.6412 | 0.0006 | |
| GSE23400 | C5AR1 | 728 | 220088_at | 0.3924 | 0.0001 | |
| GSE26886 | C5AR1 | 728 | 220088_at | 0.8758 | 0.0118 | |
| GSE29001 | C5AR1 | 728 | 220088_at | 0.4733 | 0.0291 | |
| GSE38129 | C5AR1 | 728 | 220088_at | 0.6236 | 0.0105 | |
| GSE45670 | C5AR1 | 728 | 220088_at | 0.1915 | 0.4211 | |
| GSE53622 | C5AR1 | 728 | 872 | 1.0188 | 0.0000 | |
| GSE53624 | C5AR1 | 728 | 872 | 1.5535 | 0.0000 | |
| GSE63941 | C5AR1 | 728 | 220088_at | 0.7604 | 0.2361 | |
| GSE77861 | C5AR1 | 728 | 220088_at | 0.4590 | 0.0431 | |
| GSE97050 | C5AR1 | 728 | A_23_P153562 | 0.6040 | 0.1978 | |
| SRP007169 | C5AR1 | 728 | RNAseq | 4.1160 | 0.0000 | |
| SRP008496 | C5AR1 | 728 | RNAseq | 3.1327 | 0.0000 | |
| SRP064894 | C5AR1 | 728 | RNAseq | 1.4988 | 0.0001 | |
| SRP133303 | C5AR1 | 728 | RNAseq | 1.7430 | 0.0000 | |
| SRP159526 | C5AR1 | 728 | RNAseq | 1.9978 | 0.0001 | |
| SRP193095 | C5AR1 | 728 | RNAseq | 2.4994 | 0.0000 | |
| SRP219564 | C5AR1 | 728 | RNAseq | 1.8146 | 0.0383 | |
| TCGA | C5AR1 | 728 | RNAseq | 0.2399 | 0.0861 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by C5AR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of C5AR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | C5AR1 | 728 | 4 | 4 | 22 | |
| GSE20123 | C5AR1 | 728 | 4 | 3 | 23 | |
| GSE43470 | C5AR1 | 728 | 3 | 10 | 30 | |
| GSE46452 | C5AR1 | 728 | 45 | 1 | 13 | |
| GSE47630 | C5AR1 | 728 | 8 | 7 | 25 | |
| GSE54993 | C5AR1 | 728 | 17 | 4 | 49 | |
| GSE54994 | C5AR1 | 728 | 4 | 14 | 35 | |
| GSE60625 | C5AR1 | 728 | 9 | 0 | 2 | |
| GSE74703 | C5AR1 | 728 | 3 | 7 | 26 | |
| GSE74704 | C5AR1 | 728 | 4 | 1 | 15 | |
| TCGA | C5AR1 | 728 | 15 | 18 | 63 |
Total number of gains: 116; Total number of losses: 69; Total Number of normals: 303.
Somatic mutations of C5AR1:
Generating mutation plots.
Highly correlated genes for C5AR1:
Showing top 20/1020 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| C5AR1 | FCGR3A | 0.851464 | 3 | 0 | 3 |
| C5AR1 | LRRC8C | 0.775344 | 3 | 0 | 3 |
| C5AR1 | C19orf38 | 0.758807 | 3 | 0 | 3 |
| C5AR1 | MNDA | 0.753601 | 9 | 0 | 9 |
| C5AR1 | FCER1G | 0.739552 | 11 | 0 | 9 |
| C5AR1 | PRSS36 | 0.73234 | 3 | 0 | 3 |
| C5AR1 | CD163 | 0.731213 | 12 | 0 | 10 |
| C5AR1 | SUCNR1 | 0.723992 | 4 | 0 | 4 |
| C5AR1 | FCGR2A | 0.720265 | 12 | 0 | 12 |
| C5AR1 | CCRL2 | 0.717362 | 8 | 0 | 8 |
| C5AR1 | RAB34 | 0.7158 | 3 | 0 | 3 |
| C5AR1 | SLC43A2 | 0.711418 | 5 | 0 | 5 |
| C5AR1 | IPO11 | 0.705685 | 3 | 0 | 3 |
| C5AR1 | GPR4 | 0.705008 | 5 | 0 | 5 |
| C5AR1 | FAM167B | 0.703066 | 4 | 0 | 3 |
| C5AR1 | CPT1C | 0.699387 | 4 | 0 | 4 |
| C5AR1 | LILRA6 | 0.697913 | 6 | 0 | 5 |
| C5AR1 | SIGLEC1 | 0.693258 | 6 | 0 | 6 |
| C5AR1 | PARVB | 0.692061 | 9 | 0 | 8 |
| C5AR1 | IL2RA | 0.690869 | 5 | 0 | 4 |
For details and further investigation, click here
