| Full name: C-C motif chemokine ligand 7 | Alias Symbol: MCP-3|NC28|FIC|MARC|MCP3 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 6354 | HGNC ID: HGNC:10634 | Ensembl Gene: ENSG00000108688 | OMIM ID: 158106 |
| Drug and gene relationship at DGIdb | |||
CCL7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CCL7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCL7 | 6354 | 208075_s_at | 0.1913 | 0.4530 | |
| GSE20347 | CCL7 | 6354 | 208075_s_at | 0.1157 | 0.1037 | |
| GSE23400 | CCL7 | 6354 | 208075_s_at | -0.0487 | 0.1405 | |
| GSE26886 | CCL7 | 6354 | 208075_s_at | 0.2050 | 0.0326 | |
| GSE29001 | CCL7 | 6354 | 208075_s_at | 0.1747 | 0.5524 | |
| GSE38129 | CCL7 | 6354 | 208075_s_at | 0.1377 | 0.1090 | |
| GSE45670 | CCL7 | 6354 | 208075_s_at | 0.1770 | 0.1514 | |
| GSE53622 | CCL7 | 6354 | 16186 | -0.0513 | 0.8212 | |
| GSE53624 | CCL7 | 6354 | 16186 | 0.0775 | 0.6341 | |
| GSE63941 | CCL7 | 6354 | 208075_s_at | -3.2365 | 0.0001 | |
| GSE77861 | CCL7 | 6354 | 208075_s_at | -0.0648 | 0.5071 | |
| TCGA | CCL7 | 6354 | RNAseq | 2.4720 | 0.0014 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by CCL7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCL7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCL7 | 6354 | 5 | 1 | 24 | |
| GSE20123 | CCL7 | 6354 | 5 | 1 | 24 | |
| GSE43470 | CCL7 | 6354 | 1 | 2 | 40 | |
| GSE46452 | CCL7 | 6354 | 34 | 0 | 25 | |
| GSE47630 | CCL7 | 6354 | 7 | 1 | 32 | |
| GSE54993 | CCL7 | 6354 | 3 | 3 | 64 | |
| GSE54994 | CCL7 | 6354 | 8 | 6 | 39 | |
| GSE60625 | CCL7 | 6354 | 4 | 0 | 7 | |
| GSE74703 | CCL7 | 6354 | 1 | 1 | 34 | |
| GSE74704 | CCL7 | 6354 | 3 | 1 | 16 | |
| TCGA | CCL7 | 6354 | 20 | 9 | 67 |
Total number of gains: 91; Total number of losses: 25; Total Number of normals: 372.
Somatic mutations of CCL7:
Generating mutation plots.
Highly correlated genes for CCL7:
Showing top 20/208 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCL7 | EXTL1 | 0.735106 | 3 | 0 | 3 |
| CCL7 | CRLF1 | 0.715276 | 3 | 0 | 3 |
| CCL7 | TMEM179 | 0.70155 | 3 | 0 | 3 |
| CCL7 | RIMS4 | 0.69521 | 3 | 0 | 3 |
| CCL7 | LIMD2 | 0.69161 | 3 | 0 | 3 |
| CCL7 | RHPN1 | 0.686439 | 3 | 0 | 3 |
| CCL7 | JSRP1 | 0.684224 | 3 | 0 | 3 |
| CCL7 | PPP1R12C | 0.683164 | 3 | 0 | 3 |
| CCL7 | NSMF | 0.681437 | 3 | 0 | 3 |
| CCL7 | DNAH17 | 0.679843 | 3 | 0 | 3 |
| CCL7 | OPRD1 | 0.679187 | 3 | 0 | 3 |
| CCL7 | SLC22A6 | 0.660974 | 3 | 0 | 3 |
| CCL7 | ANGPTL2 | 0.652051 | 3 | 0 | 3 |
| CCL7 | SHISA4 | 0.651759 | 3 | 0 | 3 |
| CCL7 | ZNF646 | 0.64905 | 3 | 0 | 3 |
| CCL7 | IL4I1 | 0.647845 | 4 | 0 | 4 |
| CCL7 | LTB4R2 | 0.645773 | 3 | 0 | 3 |
| CCL7 | MMP11 | 0.643622 | 3 | 0 | 3 |
| CCL7 | LINC00475 | 0.642774 | 4 | 0 | 4 |
| CCL7 | ELL | 0.640766 | 3 | 0 | 3 |
For details and further investigation, click here
