| Full name: transcription factor EB | Alias Symbol: TCFEB|bHLHe35 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 7942 | HGNC ID: HGNC:11753 | Ensembl Gene: ENSG00000112561 | OMIM ID: 600744 |
| Drug and gene relationship at DGIdb | |||
Expression of TFEB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TFEB | 7942 | 50221_at | 0.4498 | 0.5144 | |
| GSE20347 | TFEB | 7942 | 50221_at | 0.0008 | 0.9974 | |
| GSE23400 | TFEB | 7942 | 221866_at | -0.1518 | 0.0007 | |
| GSE26886 | TFEB | 7942 | 50221_at | 1.5896 | 0.0000 | |
| GSE29001 | TFEB | 7942 | 50221_at | -0.1757 | 0.5523 | |
| GSE38129 | TFEB | 7942 | 50221_at | -0.2142 | 0.2552 | |
| GSE45670 | TFEB | 7942 | 50221_at | -0.2714 | 0.1619 | |
| GSE53622 | TFEB | 7942 | 126322 | -0.0065 | 0.9378 | |
| GSE53624 | TFEB | 7942 | 126322 | 0.0556 | 0.2894 | |
| GSE63941 | TFEB | 7942 | 221866_at | 0.0690 | 0.7574 | |
| GSE77861 | TFEB | 7942 | 221866_at | -0.0860 | 0.6451 | |
| GSE97050 | TFEB | 7942 | A_33_P3398634 | 0.1156 | 0.6110 | |
| SRP007169 | TFEB | 7942 | RNAseq | -0.0623 | 0.9204 | |
| SRP064894 | TFEB | 7942 | RNAseq | 0.4795 | 0.1170 | |
| SRP133303 | TFEB | 7942 | RNAseq | -0.1382 | 0.5231 | |
| SRP159526 | TFEB | 7942 | RNAseq | -0.6180 | 0.0226 | |
| SRP193095 | TFEB | 7942 | RNAseq | 0.0823 | 0.5186 | |
| SRP219564 | TFEB | 7942 | RNAseq | 0.1714 | 0.6458 | |
| TCGA | TFEB | 7942 | RNAseq | -0.1230 | 0.1109 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TFEB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TFEB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TFEB | 7942 | 6 | 1 | 23 | |
| GSE20123 | TFEB | 7942 | 6 | 1 | 23 | |
| GSE43470 | TFEB | 7942 | 6 | 0 | 37 | |
| GSE46452 | TFEB | 7942 | 2 | 9 | 48 | |
| GSE47630 | TFEB | 7942 | 8 | 4 | 28 | |
| GSE54993 | TFEB | 7942 | 3 | 2 | 65 | |
| GSE54994 | TFEB | 7942 | 11 | 4 | 38 | |
| GSE60625 | TFEB | 7942 | 0 | 1 | 10 | |
| GSE74703 | TFEB | 7942 | 6 | 0 | 30 | |
| GSE74704 | TFEB | 7942 | 3 | 1 | 16 | |
| TCGA | TFEB | 7942 | 21 | 13 | 62 |
Total number of gains: 72; Total number of losses: 36; Total Number of normals: 380.
Somatic mutations of TFEB:
Generating mutation plots.
Highly correlated genes for TFEB:
Showing top 20/341 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TFEB | CPAMD8 | 0.760896 | 3 | 0 | 3 |
| TFEB | A1BG | 0.707218 | 3 | 0 | 3 |
| TFEB | NTSR2 | 0.703715 | 3 | 0 | 3 |
| TFEB | KLK14 | 0.702944 | 3 | 0 | 3 |
| TFEB | FAM53A | 0.702592 | 3 | 0 | 3 |
| TFEB | CSH1 | 0.694508 | 3 | 0 | 3 |
| TFEB | GRAMD1A | 0.692075 | 3 | 0 | 3 |
| TFEB | HSPG2 | 0.681846 | 6 | 0 | 5 |
| TFEB | CD248 | 0.676472 | 4 | 0 | 3 |
| TFEB | TESK1 | 0.673943 | 4 | 0 | 3 |
| TFEB | SLC2A4RG | 0.673551 | 3 | 0 | 3 |
| TFEB | SLC25A29 | 0.673083 | 3 | 0 | 3 |
| TFEB | OGG1 | 0.66694 | 4 | 0 | 3 |
| TFEB | SLC22A6 | 0.666689 | 3 | 0 | 3 |
| TFEB | RHAG | 0.66425 | 4 | 0 | 4 |
| TFEB | GGT5 | 0.660886 | 3 | 0 | 3 |
| TFEB | GSK3A | 0.659282 | 5 | 0 | 5 |
| TFEB | HOXB1 | 0.658965 | 3 | 0 | 3 |
| TFEB | EGR4 | 0.657801 | 4 | 0 | 4 |
| TFEB | FRS3 | 0.655779 | 5 | 0 | 4 |
For details and further investigation, click here
