| Full name: protein phosphatase 1 regulatory subunit 3A | Alias Symbol: GM | ||
| Type: protein-coding gene | Cytoband: 7q31.1 | ||
| Entrez ID: 5506 | HGNC ID: HGNC:9291 | Ensembl Gene: ENSG00000154415 | OMIM ID: 600917 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PPP1R3A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04910 | Insulin signaling pathway | |
| hsa04931 | Insulin resistance |
Expression of PPP1R3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R3A | 5506 | 206895_at | 0.0157 | 0.9494 | |
| GSE20347 | PPP1R3A | 5506 | 206895_at | 0.0461 | 0.5275 | |
| GSE23400 | PPP1R3A | 5506 | 206895_at | -0.0552 | 0.0356 | |
| GSE26886 | PPP1R3A | 5506 | 206895_at | -0.0238 | 0.8378 | |
| GSE29001 | PPP1R3A | 5506 | 206895_at | -0.2169 | 0.1469 | |
| GSE38129 | PPP1R3A | 5506 | 206895_at | -0.0340 | 0.5740 | |
| GSE45670 | PPP1R3A | 5506 | 206895_at | 0.1129 | 0.1796 | |
| GSE53622 | PPP1R3A | 5506 | 10977 | -0.4614 | 0.0089 | |
| GSE53624 | PPP1R3A | 5506 | 30810 | -0.4139 | 0.0079 | |
| GSE63941 | PPP1R3A | 5506 | 206895_at | -0.1272 | 0.2353 | |
| GSE77861 | PPP1R3A | 5506 | 206895_at | -0.0402 | 0.7008 | |
| TCGA | PPP1R3A | 5506 | RNAseq | 0.1060 | 0.9562 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPP1R3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R3A | 5506 | 10 | 2 | 18 | |
| GSE20123 | PPP1R3A | 5506 | 11 | 2 | 17 | |
| GSE43470 | PPP1R3A | 5506 | 3 | 2 | 38 | |
| GSE46452 | PPP1R3A | 5506 | 8 | 1 | 50 | |
| GSE47630 | PPP1R3A | 5506 | 7 | 4 | 29 | |
| GSE54993 | PPP1R3A | 5506 | 2 | 8 | 60 | |
| GSE54994 | PPP1R3A | 5506 | 11 | 5 | 37 | |
| GSE60625 | PPP1R3A | 5506 | 0 | 0 | 11 | |
| GSE74703 | PPP1R3A | 5506 | 3 | 2 | 31 | |
| GSE74704 | PPP1R3A | 5506 | 7 | 2 | 11 | |
| TCGA | PPP1R3A | 5506 | 35 | 17 | 44 |
Total number of gains: 97; Total number of losses: 45; Total Number of normals: 346.
Somatic mutations of PPP1R3A:
Generating mutation plots.
Highly correlated genes for PPP1R3A:
Showing top 20/221 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R3A | SLC6A12 | 0.706143 | 5 | 0 | 5 |
| PPP1R3A | IFNA10 | 0.692592 | 3 | 0 | 3 |
| PPP1R3A | RNPEPL1 | 0.688364 | 3 | 0 | 3 |
| PPP1R3A | IFT122 | 0.683694 | 4 | 0 | 3 |
| PPP1R3A | SRCAP | 0.672207 | 4 | 0 | 4 |
| PPP1R3A | STXBP5L | 0.670964 | 3 | 0 | 3 |
| PPP1R3A | ZMAT4 | 0.670307 | 4 | 0 | 3 |
| PPP1R3A | KCNMB2 | 0.655429 | 4 | 0 | 3 |
| PPP1R3A | CYP3A4 | 0.65468 | 3 | 0 | 3 |
| PPP1R3A | CST8 | 0.647198 | 3 | 0 | 3 |
| PPP1R3A | CYP2A7 | 0.642458 | 4 | 0 | 4 |
| PPP1R3A | DNASE2B | 0.642212 | 4 | 0 | 4 |
| PPP1R3A | SYT2 | 0.632406 | 5 | 0 | 4 |
| PPP1R3A | ADAM22 | 0.628826 | 4 | 0 | 3 |
| PPP1R3A | CAMK2A | 0.628458 | 6 | 0 | 5 |
| PPP1R3A | SLC5A7 | 0.627669 | 4 | 0 | 3 |
| PPP1R3A | KRTAP5-9 | 0.627564 | 5 | 0 | 4 |
| PPP1R3A | PSG7 | 0.625707 | 4 | 0 | 3 |
| PPP1R3A | TAOK2 | 0.624205 | 3 | 0 | 3 |
| PPP1R3A | SLC45A2 | 0.623827 | 3 | 0 | 3 |
For details and further investigation, click here
