| Full name: thyrotropin releasing hormone receptor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q23.1 | ||
| Entrez ID: 7201 | HGNC ID: HGNC:12299 | Ensembl Gene: ENSG00000174417 | OMIM ID: 188545 |
| Drug and gene relationship at DGIdb | |||
TRHR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway |
Expression of TRHR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRHR | 7201 | 211438_at | 0.0355 | 0.8833 | |
| GSE20347 | TRHR | 7201 | 211438_at | 0.0652 | 0.4726 | |
| GSE23400 | TRHR | 7201 | 211438_at | -0.0749 | 0.0412 | |
| GSE26886 | TRHR | 7201 | 211438_at | 0.0066 | 0.9665 | |
| GSE29001 | TRHR | 7201 | 211438_at | -0.0206 | 0.9157 | |
| GSE38129 | TRHR | 7201 | 211438_at | -0.0559 | 0.5233 | |
| GSE45670 | TRHR | 7201 | 211438_at | 0.1163 | 0.2554 | |
| GSE53622 | TRHR | 7201 | 49117 | 0.2537 | 0.0953 | |
| GSE53624 | TRHR | 7201 | 49117 | 0.2653 | 0.0439 | |
| GSE63941 | TRHR | 7201 | 211438_at | 0.1589 | 0.3083 | |
| GSE77861 | TRHR | 7201 | 211438_at | -0.1095 | 0.2796 | |
| GSE97050 | TRHR | 7201 | A_23_P322008 | 0.0978 | 0.6166 | |
| TCGA | TRHR | 7201 | RNAseq | 0.6106 | 0.6338 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TRHR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRHR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRHR | 7201 | 16 | 0 | 14 | |
| GSE20123 | TRHR | 7201 | 17 | 0 | 13 | |
| GSE43470 | TRHR | 7201 | 23 | 0 | 20 | |
| GSE46452 | TRHR | 7201 | 25 | 0 | 34 | |
| GSE47630 | TRHR | 7201 | 24 | 0 | 16 | |
| GSE54993 | TRHR | 7201 | 0 | 20 | 50 | |
| GSE54994 | TRHR | 7201 | 37 | 1 | 15 | |
| GSE60625 | TRHR | 7201 | 0 | 4 | 7 | |
| GSE74703 | TRHR | 7201 | 20 | 0 | 16 | |
| GSE74704 | TRHR | 7201 | 11 | 0 | 9 | |
| TCGA | TRHR | 7201 | 60 | 1 | 35 |
Total number of gains: 233; Total number of losses: 26; Total Number of normals: 229.
Somatic mutations of TRHR:
Generating mutation plots.
Highly correlated genes for TRHR:
Showing top 20/581 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRHR | LUZP4 | 0.729656 | 4 | 0 | 4 |
| TRHR | ITGB3 | 0.713335 | 4 | 0 | 4 |
| TRHR | TMEM214 | 0.71276 | 3 | 0 | 3 |
| TRHR | SLC17A1 | 0.709426 | 4 | 0 | 4 |
| TRHR | CGA | 0.706403 | 4 | 0 | 4 |
| TRHR | ATXN8OS | 0.696796 | 4 | 0 | 4 |
| TRHR | SLC6A12 | 0.693056 | 4 | 0 | 4 |
| TRHR | NEUROD2 | 0.688414 | 4 | 0 | 4 |
| TRHR | COL23A1 | 0.688068 | 3 | 0 | 3 |
| TRHR | KRT38 | 0.677472 | 4 | 0 | 4 |
| TRHR | SSTR3 | 0.677029 | 3 | 0 | 3 |
| TRHR | CNR2 | 0.673385 | 5 | 0 | 5 |
| TRHR | TGFBR1 | 0.671883 | 3 | 0 | 3 |
| TRHR | ARHGEF15 | 0.671223 | 3 | 0 | 3 |
| TRHR | BPIFA1 | 0.666652 | 4 | 0 | 4 |
| TRHR | NTNG1 | 0.665628 | 4 | 0 | 4 |
| TRHR | GML | 0.665278 | 4 | 0 | 4 |
| TRHR | SLC6A5 | 0.664309 | 4 | 0 | 4 |
| TRHR | RRH | 0.663688 | 5 | 0 | 5 |
| TRHR | MTAP | 0.663093 | 6 | 0 | 5 |
For details and further investigation, click here
