| Full name: solute carrier family 7 member 8 | Alias Symbol: LPI-PC1|LAT2 | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 23428 | HGNC ID: HGNC:11066 | Ensembl Gene: ENSG00000092068 | OMIM ID: 604235 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC7A8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC7A8 | 23428 | 202752_x_at | 0.5886 | 0.5926 | |
| GSE20347 | SLC7A8 | 23428 | 202752_x_at | 0.6647 | 0.0674 | |
| GSE23400 | SLC7A8 | 23428 | 202752_x_at | 0.6383 | 0.0000 | |
| GSE26886 | SLC7A8 | 23428 | 216092_s_at | 0.6192 | 0.0604 | |
| GSE29001 | SLC7A8 | 23428 | 216092_s_at | 0.5411 | 0.1759 | |
| GSE38129 | SLC7A8 | 23428 | 202752_x_at | 0.7025 | 0.0211 | |
| GSE45670 | SLC7A8 | 23428 | 216092_s_at | 1.0688 | 0.0109 | |
| GSE53622 | SLC7A8 | 23428 | 143368 | 0.9785 | 0.0000 | |
| GSE53624 | SLC7A8 | 23428 | 35661 | 0.7804 | 0.0000 | |
| GSE63941 | SLC7A8 | 23428 | 216092_s_at | 0.2488 | 0.8439 | |
| GSE77861 | SLC7A8 | 23428 | 202752_x_at | 1.1187 | 0.0385 | |
| GSE97050 | SLC7A8 | 23428 | A_33_P3310301 | 0.7411 | 0.1891 | |
| SRP007169 | SLC7A8 | 23428 | RNAseq | 2.2369 | 0.0000 | |
| SRP008496 | SLC7A8 | 23428 | RNAseq | 2.4568 | 0.0000 | |
| SRP064894 | SLC7A8 | 23428 | RNAseq | 1.2202 | 0.0001 | |
| SRP133303 | SLC7A8 | 23428 | RNAseq | 1.6135 | 0.0010 | |
| SRP159526 | SLC7A8 | 23428 | RNAseq | 1.2886 | 0.0795 | |
| SRP193095 | SLC7A8 | 23428 | RNAseq | 0.8395 | 0.0079 | |
| SRP219564 | SLC7A8 | 23428 | RNAseq | 1.0021 | 0.0885 | |
| TCGA | SLC7A8 | 23428 | RNAseq | 0.0217 | 0.8524 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by SLC7A8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC7A8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC7A8 | 23428 | 9 | 1 | 20 | |
| GSE20123 | SLC7A8 | 23428 | 9 | 1 | 20 | |
| GSE43470 | SLC7A8 | 23428 | 7 | 2 | 34 | |
| GSE46452 | SLC7A8 | 23428 | 17 | 2 | 40 | |
| GSE47630 | SLC7A8 | 23428 | 11 | 10 | 19 | |
| GSE54993 | SLC7A8 | 23428 | 3 | 11 | 56 | |
| GSE54994 | SLC7A8 | 23428 | 18 | 5 | 30 | |
| GSE60625 | SLC7A8 | 23428 | 0 | 2 | 9 | |
| GSE74703 | SLC7A8 | 23428 | 6 | 2 | 28 | |
| GSE74704 | SLC7A8 | 23428 | 4 | 1 | 15 | |
| TCGA | SLC7A8 | 23428 | 27 | 15 | 54 |
Total number of gains: 111; Total number of losses: 52; Total Number of normals: 325.
Somatic mutations of SLC7A8:
Generating mutation plots.
Highly correlated genes for SLC7A8:
Showing top 20/441 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC7A8 | C14orf119 | 0.719572 | 3 | 0 | 3 |
| SLC7A8 | LOX | 0.695548 | 3 | 0 | 3 |
| SLC7A8 | ADAMTS14 | 0.688628 | 3 | 0 | 3 |
| SLC7A8 | GTF2I | 0.674296 | 3 | 0 | 3 |
| SLC7A8 | AJUBA | 0.663646 | 6 | 0 | 6 |
| SLC7A8 | SATB2 | 0.659341 | 3 | 0 | 3 |
| SLC7A8 | SULT1E1 | 0.658803 | 3 | 0 | 3 |
| SLC7A8 | ALPK2 | 0.657426 | 3 | 0 | 3 |
| SLC7A8 | DLX5 | 0.648034 | 12 | 0 | 10 |
| SLC7A8 | CEACAM19 | 0.645217 | 6 | 0 | 4 |
| SLC7A8 | MB21D2 | 0.642053 | 4 | 0 | 3 |
| SLC7A8 | RBM42 | 0.637829 | 3 | 0 | 3 |
| SLC7A8 | TAPBP | 0.635128 | 3 | 0 | 3 |
| SLC7A8 | FANCM | 0.629969 | 4 | 0 | 3 |
| SLC7A8 | SLC3A2 | 0.626445 | 13 | 0 | 9 |
| SLC7A8 | GPX8 | 0.621724 | 5 | 0 | 4 |
| SLC7A8 | ZNF558 | 0.620296 | 4 | 0 | 3 |
| SLC7A8 | GDA | 0.618125 | 3 | 0 | 3 |
| SLC7A8 | ZDHHC9 | 0.614762 | 4 | 0 | 4 |
| SLC7A8 | TENM2 | 0.614548 | 7 | 0 | 5 |
For details and further investigation, click here
