| Full name: general transcription factor IIi | Alias Symbol: TFII-I|BAP-135|SPIN|BTKAP1|DIWS|IB291 | ||
| Type: protein-coding gene | Cytoband: 7q11.23 | ||
| Entrez ID: 2969 | HGNC ID: HGNC:4659 | Ensembl Gene: ENSG00000263001 | OMIM ID: 601679 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
GTF2I involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway |
Expression of GTF2I:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GTF2I | 2969 | 210892_s_at | 0.2908 | 0.5152 | |
| GSE20347 | GTF2I | 2969 | 210892_s_at | 0.2346 | 0.0258 | |
| GSE23400 | GTF2I | 2969 | 210892_s_at | 0.3391 | 0.0000 | |
| GSE26886 | GTF2I | 2969 | 210892_s_at | 0.1970 | 0.3095 | |
| GSE29001 | GTF2I | 2969 | 210892_s_at | 0.4604 | 0.0093 | |
| GSE38129 | GTF2I | 2969 | 210892_s_at | 0.2688 | 0.0024 | |
| GSE45670 | GTF2I | 2969 | 210892_s_at | 0.3509 | 0.0100 | |
| GSE53622 | GTF2I | 2969 | 139829 | -0.1023 | 0.1229 | |
| GSE53624 | GTF2I | 2969 | 10577 | 0.0596 | 0.3220 | |
| GSE63941 | GTF2I | 2969 | 210892_s_at | 3.2468 | 0.0000 | |
| GSE77861 | GTF2I | 2969 | 210892_s_at | 0.0294 | 0.9169 | |
| GSE97050 | GTF2I | 2969 | A_23_P168567 | -0.4100 | 0.2842 | |
| SRP007169 | GTF2I | 2969 | RNAseq | 1.2614 | 0.0025 | |
| SRP008496 | GTF2I | 2969 | RNAseq | 1.1784 | 0.0003 | |
| SRP064894 | GTF2I | 2969 | RNAseq | -0.0794 | 0.8191 | |
| SRP133303 | GTF2I | 2969 | RNAseq | 0.1768 | 0.1138 | |
| SRP159526 | GTF2I | 2969 | RNAseq | -0.1281 | 0.6031 | |
| SRP193095 | GTF2I | 2969 | RNAseq | 0.1097 | 0.3212 | |
| SRP219564 | GTF2I | 2969 | RNAseq | -0.0852 | 0.8398 | |
| TCGA | GTF2I | 2969 | RNAseq | -0.0029 | 0.9528 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by GTF2I expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GTF2I:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GTF2I | 2969 | 14 | 1 | 15 | |
| GSE20123 | GTF2I | 2969 | 14 | 1 | 15 | |
| GSE43470 | GTF2I | 2969 | 3 | 2 | 38 | |
| GSE46452 | GTF2I | 2969 | 12 | 0 | 47 | |
| GSE47630 | GTF2I | 2969 | 7 | 2 | 31 | |
| GSE54993 | GTF2I | 2969 | 2 | 7 | 61 | |
| GSE54994 | GTF2I | 2969 | 14 | 2 | 37 | |
| GSE60625 | GTF2I | 2969 | 0 | 0 | 11 | |
| GSE74703 | GTF2I | 2969 | 3 | 1 | 32 | |
| GSE74704 | GTF2I | 2969 | 8 | 1 | 11 | |
| TCGA | GTF2I | 2969 | 44 | 7 | 45 |
Total number of gains: 121; Total number of losses: 24; Total Number of normals: 343.
Somatic mutations of GTF2I:
Generating mutation plots.
Highly correlated genes for GTF2I:
Showing top 20/290 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GTF2I | MRPL38 | 0.695079 | 4 | 0 | 3 |
| GTF2I | CNOT10 | 0.694741 | 3 | 0 | 3 |
| GTF2I | ASXL2 | 0.692895 | 4 | 0 | 4 |
| GTF2I | RNF139 | 0.683402 | 3 | 0 | 3 |
| GTF2I | FBXO11 | 0.683328 | 3 | 0 | 3 |
| GTF2I | KLHL23 | 0.682661 | 3 | 0 | 3 |
| GTF2I | SLC7A8 | 0.674296 | 3 | 0 | 3 |
| GTF2I | RRNAD1 | 0.66568 | 3 | 0 | 3 |
| GTF2I | KLHDC3 | 0.648232 | 4 | 0 | 3 |
| GTF2I | UBL7 | 0.6471 | 4 | 0 | 3 |
| GTF2I | RAB5C | 0.638979 | 3 | 0 | 3 |
| GTF2I | DNAH1 | 0.638364 | 3 | 0 | 3 |
| GTF2I | FRAT2 | 0.638175 | 3 | 0 | 3 |
| GTF2I | ECI1 | 0.636824 | 4 | 0 | 3 |
| GTF2I | AIP | 0.636821 | 4 | 0 | 4 |
| GTF2I | ALKBH7 | 0.635555 | 3 | 0 | 3 |
| GTF2I | CYB561A3 | 0.631399 | 3 | 0 | 3 |
| GTF2I | METTL8 | 0.629373 | 3 | 0 | 3 |
| GTF2I | M6PR | 0.625018 | 7 | 0 | 7 |
| GTF2I | CTDSPL2 | 0.624956 | 4 | 0 | 3 |
For details and further investigation, click here
