AJUBA

 

Full name: ajuba LIM protein Alias Symbol: MGC15563
Type: protein-coding gene Cytoband: 14q11.2
Entrez ID: 84962 HGNC ID: HGNC:20250 Ensembl Gene: ENSG00000129474 OMIM ID: 609066
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

AJUBA involved pathways:

KEGG pathway Description View
hsa04390Hippo signaling pathway

 

Expression of AJUBA:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 AJUBA 84962 225806_at 0.6627 0.4385
GSE26886 AJUBA 84962 225806_at 0.0405 0.9192
GSE45670 AJUBA 84962 225806_at 1.0906 0.0001
GSE53622 AJUBA 84962 125908 1.0818 0.0000
GSE53624 AJUBA 84962 125908 1.1150 0.0000
GSE63941 AJUBA 84962 225806_at 1.5797 0.0192
GSE77861 AJUBA 84962 225806_at 0.7572 0.0301
GSE97050 AJUBA 84962 A_23_P54055 0.8980 0.1686
SRP007169 AJUBA 84962 RNAseq 1.0031 0.0652
SRP008496 AJUBA 84962 RNAseq 0.8762 0.0073
SRP064894 AJUBA 84962 RNAseq 0.7984 0.0149
SRP133303 AJUBA 84962 RNAseq 0.7103 0.0145
SRP159526 AJUBA 84962 RNAseq 0.7089 0.0971
SRP193095 AJUBA 84962 RNAseq 0.3255 0.2637
SRP219564 AJUBA 84962 RNAseq 0.1345 0.8323

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by AJUBA expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of AJUBA:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 AJUBA 84962 9 2 19
GSE20123 AJUBA 84962 9 2 19
GSE43470 AJUBA 84962 7 2 34
GSE46452 AJUBA 84962 17 2 40
GSE47630 AJUBA 84962 11 10 19
GSE54993 AJUBA 84962 3 11 56
GSE54994 AJUBA 84962 18 5 30
GSE60625 AJUBA 84962 0 2 9
GSE74703 AJUBA 84962 6 2 28
GSE74704 AJUBA 84962 4 1 15
TCGA AJUBA 84962 27 15 54

Total number of gains: 111; Total number of losses: 54; Total Number of normals: 323.  

 

Somatic mutations of AJUBA:

 

Generating mutation plots.

 

Highly correlated genes for AJUBA:

 

Showing top 20/1230 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
AJUBAADAMTS140.756482303
AJUBAKPNA20.755172404
AJUBAACP10.748653303
AJUBANIPA20.746922303
AJUBAGINS40.742936303
AJUBASLC38A60.736721303
AJUBAHSPA90.723248303
AJUBABUB10.723004606
AJUBAG3BP10.718282404
AJUBAKIAA09300.717276505
AJUBAMGAT20.717073505
AJUBAC1orf1120.716832404
AJUBASLC9A10.715405303
AJUBAGPR1530.714841303
AJUBASLC15A20.712357303
AJUBAFARSA0.708636404
AJUBAFANCM0.707899504
AJUBADUSP180.706693303
AJUBASNX130.705646505
AJUBASKA10.70552505

For details and further investigation, click here