| Full name: lysyl oxidase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q23.1 | ||
| Entrez ID: 4015 | HGNC ID: HGNC:6664 | Ensembl Gene: ENSG00000113083 | OMIM ID: 153455 |
| Drug and gene relationship at DGIdb | |||
Expression of LOX:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LOX | 4015 | 215446_s_at | 2.0007 | 0.1909 | |
| GSE20347 | LOX | 4015 | 215446_s_at | 1.6269 | 0.0003 | |
| GSE23400 | LOX | 4015 | 213640_s_at | 0.1392 | 0.0002 | |
| GSE26886 | LOX | 4015 | 215446_s_at | 0.6182 | 0.4607 | |
| GSE29001 | LOX | 4015 | 215446_s_at | 2.1340 | 0.0005 | |
| GSE38129 | LOX | 4015 | 215446_s_at | 1.7607 | 0.0000 | |
| GSE45670 | LOX | 4015 | 215446_s_at | 1.7161 | 0.0035 | |
| GSE53622 | LOX | 4015 | 34244 | 2.2360 | 0.0000 | |
| GSE53624 | LOX | 4015 | 34244 | 2.0665 | 0.0000 | |
| GSE63941 | LOX | 4015 | 215446_s_at | -6.4859 | 0.0015 | |
| GSE77861 | LOX | 4015 | 215446_s_at | 1.3615 | 0.1552 | |
| GSE97050 | LOX | 4015 | A_23_P122216 | 1.9135 | 0.0631 | |
| SRP007169 | LOX | 4015 | RNAseq | 2.4202 | 0.0000 | |
| SRP008496 | LOX | 4015 | RNAseq | 2.5005 | 0.0000 | |
| SRP064894 | LOX | 4015 | RNAseq | 2.8196 | 0.0000 | |
| SRP133303 | LOX | 4015 | RNAseq | 2.8420 | 0.0000 | |
| SRP159526 | LOX | 4015 | RNAseq | 0.9659 | 0.0023 | |
| SRP193095 | LOX | 4015 | RNAseq | 1.5944 | 0.0000 | |
| SRP219564 | LOX | 4015 | RNAseq | 2.8000 | 0.0000 | |
| TCGA | LOX | 4015 | RNAseq | 0.4073 | 0.0012 |
Upregulated datasets: 12; Downregulated datasets: 1.
Survival by LOX expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LOX:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LOX | 4015 | 1 | 13 | 16 | |
| GSE20123 | LOX | 4015 | 1 | 13 | 16 | |
| GSE43470 | LOX | 4015 | 3 | 8 | 32 | |
| GSE46452 | LOX | 4015 | 0 | 27 | 32 | |
| GSE47630 | LOX | 4015 | 0 | 21 | 19 | |
| GSE54993 | LOX | 4015 | 9 | 1 | 60 | |
| GSE54994 | LOX | 4015 | 2 | 14 | 37 | |
| GSE60625 | LOX | 4015 | 0 | 0 | 11 | |
| GSE74703 | LOX | 4015 | 2 | 6 | 28 | |
| GSE74704 | LOX | 4015 | 1 | 7 | 12 | |
| TCGA | LOX | 4015 | 3 | 40 | 53 |
Total number of gains: 22; Total number of losses: 150; Total Number of normals: 316.
Somatic mutations of LOX:
Generating mutation plots.
Highly correlated genes for LOX:
Showing top 20/732 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LOX | IL4I1 | 0.740867 | 3 | 0 | 3 |
| LOX | ARSI | 0.728691 | 6 | 0 | 6 |
| LOX | ZNF469 | 0.709771 | 7 | 0 | 6 |
| LOX | PMEPA1 | 0.703283 | 7 | 0 | 7 |
| LOX | SLC7A8 | 0.695548 | 3 | 0 | 3 |
| LOX | OLFML2B | 0.69262 | 10 | 0 | 8 |
| LOX | DCBLD1 | 0.690235 | 7 | 0 | 6 |
| LOX | SPON2 | 0.688815 | 3 | 0 | 3 |
| LOX | LRRC8C | 0.686486 | 3 | 0 | 3 |
| LOX | SIRPA | 0.685649 | 8 | 0 | 8 |
| LOX | MFAP2 | 0.684297 | 9 | 0 | 7 |
| LOX | ZNF148 | 0.67832 | 3 | 0 | 3 |
| LOX | PDCD1LG2 | 0.672246 | 4 | 0 | 4 |
| LOX | LOXL1 | 0.671004 | 7 | 0 | 7 |
| LOX | GPX8 | 0.6703 | 7 | 0 | 5 |
| LOX | CDH11 | 0.669984 | 10 | 0 | 8 |
| LOX | NOX4 | 0.66914 | 10 | 0 | 8 |
| LOX | THY1 | 0.666959 | 11 | 0 | 9 |
| LOX | FAM91A1 | 0.665839 | 5 | 0 | 5 |
| LOX | INHBA | 0.664497 | 10 | 0 | 8 |
For details and further investigation, click here
