MYLK

 

Full name: myosin light chain kinase Alias Symbol: MLCK|smMLCK|MYLK1|MLCK1
Type: protein-coding gene Cytoband: 3q21.1
Entrez ID: 4638 HGNC ID: HGNC:7590 Ensembl Gene: ENSG00000065534 OMIM ID: 600922
Drug and gene relationship at DGIdb

 

MYLK involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04510Focal adhesion
hsa04611Platelet activation
hsa04810Regulation of actin cytoskeleton
hsa04921Oxytocin signaling pathway
hsa04971Gastric acid secretion

 

Expression of MYLK:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MYLK 4638 224823_at -1.3574 0.2838
GSE20347 MYLK 4638 202555_s_at 0.5039 0.3670
GSE23400 MYLK 4638 202555_s_at -0.6592 0.0174
GSE26886 MYLK 4638 224823_at 2.2860 0.0024
GSE29001 MYLK 4638 202555_s_at -0.1730 0.8626
GSE38129 MYLK 4638 202555_s_at -0.3130 0.5860
GSE45670 MYLK 4638 224823_at -2.5792 0.0000
GSE53622 MYLK 4638 119288 -1.4502 0.0000
GSE53624 MYLK 4638 119288 -1.1311 0.0000
GSE63941 MYLK 4638 224823_at -5.3581 0.0082
GSE77861 MYLK 4638 202555_s_at 1.6179 0.0215
GSE97050 MYLK 4638 A_23_P143817 -1.7268 0.0899
SRP007169 MYLK 4638 RNAseq 3.4428 0.0000
SRP008496 MYLK 4638 RNAseq 3.7744 0.0000
SRP064894 MYLK 4638 RNAseq -0.3213 0.4599
SRP133303 MYLK 4638 RNAseq -1.1012 0.0020
SRP159526 MYLK 4638 RNAseq -0.6266 0.2718
SRP193095 MYLK 4638 RNAseq 1.3709 0.0001
SRP219564 MYLK 4638 RNAseq -0.8125 0.4945
TCGA MYLK 4638 RNAseq -0.3654 0.0042

Upregulated datasets: 5; Downregulated datasets: 5.  

 

Survival by MYLK expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MYLK:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MYLK 4638 17 0 13
GSE20123 MYLK 4638 17 0 13
GSE43470 MYLK 4638 20 0 23
GSE46452 MYLK 4638 14 5 40
GSE47630 MYLK 4638 17 4 19
GSE54993 MYLK 4638 2 7 61
GSE54994 MYLK 4638 30 4 19
GSE60625 MYLK 4638 0 6 5
GSE74703 MYLK 4638 16 0 20
GSE74704 MYLK 4638 13 0 7
TCGA MYLK 4638 54 6 36

Total number of gains: 200; Total number of losses: 32; Total Number of normals: 256.  

 

Somatic mutations of MYLK:

 

Generating mutation plots.

 

Highly correlated genes for MYLK:

 

Showing top 20/987 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MYLKTPM10.85270313013
MYLKACTA20.85268313013
MYLKACTBL20.85049303
MYLKTPM20.83001913013
MYLKTAGLN0.82450512012
MYLKACTG20.8228713013
MYLKPDLIM30.79933413013
MYLKCNN10.79860411011
MYLKMYOCD0.798475707
MYLKUBXN100.797644303
MYLKNEXN0.787413909
MYLKSORCS10.784561404
MYLKSMOC20.784407707
MYLKRASSF30.782874404
MYLKSLITRK30.781646707
MYLKMRVI10.781093807
MYLKPGM50.780203808
MYLKFERMT20.77915613013
MYLKPLN0.77656913013
MYLKTMEM470.77643313013

For details and further investigation, click here