| Full name: solute carrier organic anion transporter family member 1B3 | Alias Symbol: OATP8|OATP1B3 | ||
| Type: protein-coding gene | Cytoband: 12p12.2 | ||
| Entrez ID: 28234 | HGNC ID: HGNC:10961 | Ensembl Gene: ENSG00000111700 | OMIM ID: 605495 |
| Drug and gene relationship at DGIdb | |||
SLCO1B3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04976 | Bile secretion |
Expression of SLCO1B3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLCO1B3 | 28234 | 206354_at | 1.0733 | 0.5204 | |
| GSE20347 | SLCO1B3 | 28234 | 206354_at | 1.6101 | 0.0017 | |
| GSE23400 | SLCO1B3 | 28234 | 206354_at | 0.7350 | 0.0000 | |
| GSE26886 | SLCO1B3 | 28234 | 206354_at | 3.0326 | 0.0000 | |
| GSE29001 | SLCO1B3 | 28234 | 206354_at | 1.9562 | 0.0166 | |
| GSE38129 | SLCO1B3 | 28234 | 206354_at | 1.7229 | 0.0000 | |
| GSE45670 | SLCO1B3 | 28234 | 206354_at | 2.6393 | 0.0123 | |
| GSE63941 | SLCO1B3 | 28234 | 206354_at | 3.4141 | 0.0651 | |
| GSE77861 | SLCO1B3 | 28234 | 206354_at | 1.4597 | 0.0640 | |
| GSE97050 | SLCO1B3 | 28234 | A_33_P3364089 | 0.5774 | 0.2556 | |
| SRP007169 | SLCO1B3 | 28234 | RNAseq | 9.6540 | 0.0000 | |
| TCGA | SLCO1B3 | 28234 | RNAseq | 3.1615 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by SLCO1B3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SLCO1B3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLCO1B3 | 28234 | 9 | 3 | 18 | |
| GSE20123 | SLCO1B3 | 28234 | 9 | 3 | 18 | |
| GSE43470 | SLCO1B3 | 28234 | 9 | 4 | 30 | |
| GSE46452 | SLCO1B3 | 28234 | 10 | 1 | 48 | |
| GSE47630 | SLCO1B3 | 28234 | 14 | 1 | 25 | |
| GSE54993 | SLCO1B3 | 28234 | 1 | 9 | 60 | |
| GSE54994 | SLCO1B3 | 28234 | 12 | 2 | 39 | |
| GSE60625 | SLCO1B3 | 28234 | 0 | 1 | 10 | |
| GSE74703 | SLCO1B3 | 28234 | 9 | 3 | 24 | |
| GSE74704 | SLCO1B3 | 28234 | 6 | 2 | 12 | |
| TCGA | SLCO1B3 | 28234 | 42 | 5 | 49 |
Total number of gains: 121; Total number of losses: 34; Total Number of normals: 333.
Somatic mutations of SLCO1B3:
Generating mutation plots.
Highly correlated genes for SLCO1B3:
Showing top 20/784 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLCO1B3 | IL31RA | 0.778163 | 4 | 0 | 4 |
| SLCO1B3 | GALNT18 | 0.748623 | 3 | 0 | 3 |
| SLCO1B3 | FANCM | 0.738572 | 3 | 0 | 3 |
| SLCO1B3 | TENM2 | 0.729938 | 4 | 0 | 4 |
| SLCO1B3 | MUCL1 | 0.716748 | 3 | 0 | 3 |
| SLCO1B3 | L3HYPDH | 0.710089 | 3 | 0 | 3 |
| SLCO1B3 | MPLKIP | 0.707969 | 3 | 0 | 3 |
| SLCO1B3 | FIBP | 0.702585 | 3 | 0 | 3 |
| SLCO1B3 | FAM169A | 0.696288 | 5 | 0 | 5 |
| SLCO1B3 | RHPN2 | 0.68929 | 4 | 0 | 3 |
| SLCO1B3 | WDR54 | 0.686432 | 5 | 0 | 5 |
| SLCO1B3 | ARHGEF10 | 0.686328 | 3 | 0 | 3 |
| SLCO1B3 | OCIAD2 | 0.685283 | 5 | 0 | 5 |
| SLCO1B3 | TMEM92 | 0.683828 | 3 | 0 | 3 |
| SLCO1B3 | LINC00460 | 0.677017 | 3 | 0 | 3 |
| SLCO1B3 | SF3A2 | 0.67486 | 3 | 0 | 3 |
| SLCO1B3 | SIX4 | 0.674846 | 5 | 0 | 4 |
| SLCO1B3 | DLX4 | 0.669872 | 3 | 0 | 3 |
| SLCO1B3 | XPO5 | 0.664122 | 3 | 0 | 3 |
| SLCO1B3 | POU6F2-AS2 | 0.660473 | 4 | 0 | 3 |
For details and further investigation, click here
