| Full name: ubiquitin specific peptidase 22 | Alias Symbol: KIAA1063 | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 23326 | HGNC ID: HGNC:12621 | Ensembl Gene: ENSG00000124422 | OMIM ID: 612116 |
| Drug and gene relationship at DGIdb | |||
Expression of USP22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USP22 | 23326 | 200083_at | 0.6513 | 0.0331 | |
| GSE20347 | USP22 | 23326 | 200083_at | 0.2774 | 0.0170 | |
| GSE23400 | USP22 | 23326 | 200083_at | 0.4428 | 0.0000 | |
| GSE26886 | USP22 | 23326 | 200083_at | 0.2890 | 0.0773 | |
| GSE29001 | USP22 | 23326 | 200083_at | 0.3818 | 0.1859 | |
| GSE38129 | USP22 | 23326 | 200083_at | 0.4223 | 0.0003 | |
| GSE45670 | USP22 | 23326 | 200083_at | 0.4330 | 0.0002 | |
| GSE53622 | USP22 | 23326 | 11757 | 0.3880 | 0.0000 | |
| GSE53624 | USP22 | 23326 | 11757 | 0.3800 | 0.0000 | |
| GSE63941 | USP22 | 23326 | 200083_at | -0.5805 | 0.3627 | |
| GSE77861 | USP22 | 23326 | 200083_at | 0.4727 | 0.0366 | |
| GSE97050 | USP22 | 23326 | A_23_P422540 | 0.1665 | 0.5065 | |
| SRP007169 | USP22 | 23326 | RNAseq | 0.2768 | 0.3897 | |
| SRP008496 | USP22 | 23326 | RNAseq | 0.2162 | 0.3256 | |
| SRP064894 | USP22 | 23326 | RNAseq | 0.7635 | 0.0000 | |
| SRP133303 | USP22 | 23326 | RNAseq | 0.2678 | 0.0756 | |
| SRP159526 | USP22 | 23326 | RNAseq | 0.4074 | 0.0899 | |
| SRP193095 | USP22 | 23326 | RNAseq | 0.2528 | 0.0008 | |
| SRP219564 | USP22 | 23326 | RNAseq | 0.2885 | 0.3602 | |
| TCGA | USP22 | 23326 | RNAseq | -0.1277 | 0.0024 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by USP22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of USP22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USP22 | 23326 | 4 | 5 | 21 | |
| GSE20123 | USP22 | 23326 | 4 | 6 | 20 | |
| GSE43470 | USP22 | 23326 | 1 | 5 | 37 | |
| GSE46452 | USP22 | 23326 | 34 | 1 | 24 | |
| GSE47630 | USP22 | 23326 | 7 | 1 | 32 | |
| GSE54993 | USP22 | 23326 | 2 | 4 | 64 | |
| GSE54994 | USP22 | 23326 | 6 | 6 | 41 | |
| GSE60625 | USP22 | 23326 | 4 | 0 | 7 | |
| GSE74703 | USP22 | 23326 | 1 | 2 | 33 | |
| GSE74704 | USP22 | 23326 | 2 | 2 | 16 | |
| TCGA | USP22 | 23326 | 18 | 24 | 54 |
Total number of gains: 83; Total number of losses: 56; Total Number of normals: 349.
Somatic mutations of USP22:
Generating mutation plots.
Highly correlated genes for USP22:
Showing top 20/1554 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USP22 | NEK3 | 0.794868 | 3 | 0 | 3 |
| USP22 | KLHL36 | 0.79254 | 3 | 0 | 3 |
| USP22 | LRRC58 | 0.782439 | 3 | 0 | 3 |
| USP22 | ALG1 | 0.767629 | 3 | 0 | 3 |
| USP22 | USP12 | 0.765802 | 3 | 0 | 3 |
| USP22 | SMAD1 | 0.76202 | 3 | 0 | 3 |
| USP22 | PET117 | 0.755804 | 3 | 0 | 3 |
| USP22 | KBTBD6 | 0.743331 | 5 | 0 | 4 |
| USP22 | TYW5 | 0.740557 | 3 | 0 | 3 |
| USP22 | GAS2L1 | 0.740427 | 4 | 0 | 3 |
| USP22 | ARHGAP18 | 0.740068 | 3 | 0 | 3 |
| USP22 | PKIG | 0.739229 | 3 | 0 | 3 |
| USP22 | ARF3 | 0.73691 | 3 | 0 | 3 |
| USP22 | TMTC4 | 0.733085 | 5 | 0 | 4 |
| USP22 | RAB34 | 0.725802 | 3 | 0 | 3 |
| USP22 | FLVCR1 | 0.724633 | 5 | 0 | 4 |
| USP22 | ZBTB2 | 0.722268 | 4 | 0 | 4 |
| USP22 | UHMK1 | 0.722213 | 5 | 0 | 5 |
| USP22 | APLP2 | 0.719051 | 3 | 0 | 3 |
| USP22 | ZGPAT | 0.716679 | 3 | 0 | 3 |
For details and further investigation, click here
