KRI1

 

Full name: KRI1 homolog Alias Symbol: FLJ12949
Type: protein-coding gene Cytoband: 19p13.2
Entrez ID: 65095 HGNC ID: HGNC:25769 Ensembl Gene: ENSG00000129347 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of KRI1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KRI1 65095 218798_at 0.6417 0.0929
GSE20347 KRI1 65095 218798_at 0.4267 0.0000
GSE23400 KRI1 65095 218798_at 0.3237 0.0000
GSE26886 KRI1 65095 218798_at 0.2695 0.1623
GSE29001 KRI1 65095 218798_at 0.3534 0.1835
GSE38129 KRI1 65095 218798_at 0.3873 0.0000
GSE45670 KRI1 65095 218798_at 0.4326 0.0004
GSE53622 KRI1 65095 11839 0.5403 0.0000
GSE53624 KRI1 65095 11839 0.5648 0.0000
GSE63941 KRI1 65095 218798_at 0.8448 0.0046
GSE77861 KRI1 65095 218798_at 0.3494 0.0731
GSE97050 KRI1 65095 A_23_P101332 0.4083 0.1725
SRP007169 KRI1 65095 RNAseq 1.5402 0.0014
SRP008496 KRI1 65095 RNAseq 1.4331 0.0003
SRP064894 KRI1 65095 RNAseq 0.9039 0.0000
SRP133303 KRI1 65095 RNAseq 0.3131 0.0418
SRP159526 KRI1 65095 RNAseq 0.6488 0.0358
SRP193095 KRI1 65095 RNAseq 0.5082 0.0004
SRP219564 KRI1 65095 RNAseq 0.8788 0.0617
TCGA KRI1 65095 RNAseq 0.3127 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by KRI1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of KRI1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KRI1 65095 4 3 23
GSE20123 KRI1 65095 3 1 26
GSE43470 KRI1 65095 3 6 34
GSE46452 KRI1 65095 47 1 11
GSE47630 KRI1 65095 4 7 29
GSE54993 KRI1 65095 16 3 51
GSE54994 KRI1 65095 6 13 34
GSE60625 KRI1 65095 9 0 2
GSE74703 KRI1 65095 3 4 29
GSE74704 KRI1 65095 0 1 19
TCGA KRI1 65095 15 14 67

Total number of gains: 110; Total number of losses: 53; Total Number of normals: 325.  

 

Somatic mutations of KRI1:

 

Generating mutation plots.

 

Highly correlated genes for KRI1:

 

Showing top 20/1666 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KRI1PACS10.784433303
KRI1SMAD10.779513303
KRI1GSK3A0.772221303
KRI1CD220.768365303
KRI1SCAF10.764481303
KRI1ARHGEF110.758048303
KRI1FAM53B0.739836303
KRI1SAPCD20.736762606
KRI1RECQL0.735162303
KRI1TFDP10.733988303
KRI1PPP5C0.733492504
KRI1DHX300.733263303
KRI1NDUFA90.731383303
KRI1SPIRE20.731283404
KRI1PTCD10.7261303
KRI1NT5DC20.721604303
KRI1LRRC580.719337403
KRI1ANKRD540.717882303
KRI1AUNIP0.713396707
KRI1GPR1600.712859303

For details and further investigation, click here