SMC1A

 

Full name: structural maintenance of chromosomes 1A Alias Symbol: DXS423E|KIAA0178|SB1.8|Smcb
Type: protein-coding gene Cytoband: Xp11.22
Entrez ID: 8243 HGNC ID: HGNC:11111 Ensembl Gene: ENSG00000072501 OMIM ID: 300040
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 288/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

SMC1A involved pathways:

KEGG pathway Description View
hsa04110Cell cycle

 

Expression of SMC1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SMC1A 8243 201589_at 0.6202 0.0867
GSE20347 SMC1A 8243 201589_at 0.3387 0.0818
GSE23400 SMC1A 8243 201589_at 0.6329 0.0000
GSE26886 SMC1A 8243 201589_at 0.5838 0.0111
GSE29001 SMC1A 8243 201589_at 0.5746 0.1556
GSE38129 SMC1A 8243 201589_at 0.4101 0.0049
GSE45670 SMC1A 8243 201589_at 0.2820 0.0893
GSE53622 SMC1A 8243 135412 0.1863 0.0028
GSE53624 SMC1A 8243 135412 0.6705 0.0000
GSE63941 SMC1A 8243 201589_at 0.2609 0.4696
GSE77861 SMC1A 8243 201589_at 0.3753 0.0925
GSE97050 SMC1A 8243 A_33_P3290909 0.4979 0.1204
SRP007169 SMC1A 8243 RNAseq 2.4543 0.0000
SRP008496 SMC1A 8243 RNAseq 2.0973 0.0000
SRP064894 SMC1A 8243 RNAseq 0.4512 0.0761
SRP133303 SMC1A 8243 RNAseq 0.3232 0.1281
SRP159526 SMC1A 8243 RNAseq 0.5502 0.0187
SRP193095 SMC1A 8243 RNAseq 0.3308 0.0093
SRP219564 SMC1A 8243 RNAseq 0.4906 0.2141
TCGA SMC1A 8243 RNAseq 0.0441 0.3072

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by SMC1A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SMC1A:

 

No record found for this gene.

 

Somatic mutations of SMC1A:

 

Generating mutation plots.

 

Highly correlated genes for SMC1A:

 

Showing top 20/1128 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SMC1AZDHHC70.753788303
SMC1AINTS100.730528303
SMC1AANKIB10.721571303
SMC1ALRRC8B0.71801303
SMC1ARCN20.690253909
SMC1ASDHAF20.688076303
SMC1AASH2L0.686429303
SMC1AFYN0.685789303
SMC1ABIRC20.678426404
SMC1ACYBA0.670879303
SMC1ASTX20.666229303
SMC1ACDK40.664861908
SMC1ANRM0.661193403
SMC1ALARS20.659834404
SMC1ATET10.65793403
SMC1ANOL110.657872908
SMC1ASLC35A20.656824606
SMC1ASMCR80.655993403
SMC1AUBTD20.652686404
SMC1AELAVL10.652431808

For details and further investigation, click here