| Full name: leucyl-tRNA synthetase 2, mitochondrial | Alias Symbol: KIAA0028|LEURS|MGC26121|mtLeuRS | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 23395 | HGNC ID: HGNC:17095 | Ensembl Gene: ENSG00000011376 | OMIM ID: 604544 |
| Drug and gene relationship at DGIdb | |||
Expression of LARS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LARS2 | 23395 | 34764_at | 0.6003 | 0.3028 | |
| GSE20347 | LARS2 | 23395 | 204016_at | 0.0786 | 0.4306 | |
| GSE23400 | LARS2 | 23395 | 204016_at | -0.0796 | 0.0859 | |
| GSE26886 | LARS2 | 23395 | 34764_at | 0.9566 | 0.0009 | |
| GSE29001 | LARS2 | 23395 | 34764_at | 0.1624 | 0.6439 | |
| GSE38129 | LARS2 | 23395 | 204016_at | 0.0037 | 0.9672 | |
| GSE45670 | LARS2 | 23395 | 34764_at | 0.3126 | 0.0385 | |
| GSE53622 | LARS2 | 23395 | 131021 | 0.0106 | 0.9145 | |
| GSE53624 | LARS2 | 23395 | 131021 | 0.1876 | 0.0182 | |
| GSE63941 | LARS2 | 23395 | 34764_at | -0.3154 | 0.4168 | |
| GSE77861 | LARS2 | 23395 | 204016_at | -0.2251 | 0.2938 | |
| GSE97050 | LARS2 | 23395 | A_23_P212397 | 0.1835 | 0.4399 | |
| SRP007169 | LARS2 | 23395 | RNAseq | 0.7624 | 0.0777 | |
| SRP008496 | LARS2 | 23395 | RNAseq | 0.6644 | 0.0128 | |
| SRP064894 | LARS2 | 23395 | RNAseq | 0.0247 | 0.8874 | |
| SRP133303 | LARS2 | 23395 | RNAseq | 0.1606 | 0.4130 | |
| SRP159526 | LARS2 | 23395 | RNAseq | 0.2992 | 0.2173 | |
| SRP193095 | LARS2 | 23395 | RNAseq | 0.0024 | 0.9787 | |
| SRP219564 | LARS2 | 23395 | RNAseq | -0.0173 | 0.9542 | |
| TCGA | LARS2 | 23395 | RNAseq | -0.0760 | 0.1552 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LARS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LARS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LARS2 | 23395 | 0 | 17 | 13 | |
| GSE20123 | LARS2 | 23395 | 0 | 18 | 12 | |
| GSE43470 | LARS2 | 23395 | 0 | 20 | 23 | |
| GSE46452 | LARS2 | 23395 | 2 | 17 | 40 | |
| GSE47630 | LARS2 | 23395 | 1 | 24 | 15 | |
| GSE54993 | LARS2 | 23395 | 7 | 2 | 61 | |
| GSE54994 | LARS2 | 23395 | 0 | 36 | 17 | |
| GSE60625 | LARS2 | 23395 | 5 | 0 | 6 | |
| GSE74703 | LARS2 | 23395 | 0 | 15 | 21 | |
| GSE74704 | LARS2 | 23395 | 0 | 12 | 8 | |
| TCGA | LARS2 | 23395 | 1 | 75 | 20 |
Total number of gains: 16; Total number of losses: 236; Total Number of normals: 236.
Somatic mutations of LARS2:
Generating mutation plots.
Highly correlated genes for LARS2:
Showing top 20/518 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LARS2 | MEF2A | 0.803421 | 3 | 0 | 3 |
| LARS2 | ITGA3 | 0.78384 | 3 | 0 | 3 |
| LARS2 | ATRIP | 0.783005 | 3 | 0 | 3 |
| LARS2 | TRMT61B | 0.777063 | 3 | 0 | 3 |
| LARS2 | ITPR3 | 0.755349 | 3 | 0 | 3 |
| LARS2 | SEC22C | 0.747676 | 3 | 0 | 3 |
| LARS2 | ZNF70 | 0.742931 | 3 | 0 | 3 |
| LARS2 | PDHX | 0.73397 | 3 | 0 | 3 |
| LARS2 | NUF2 | 0.732646 | 4 | 0 | 4 |
| LARS2 | YY1 | 0.726501 | 4 | 0 | 4 |
| LARS2 | TSPAN17 | 0.725046 | 3 | 0 | 3 |
| LARS2 | TMEM223 | 0.723242 | 4 | 0 | 4 |
| LARS2 | PLEKHJ1 | 0.72031 | 3 | 0 | 3 |
| LARS2 | IRF2BPL | 0.718323 | 3 | 0 | 3 |
| LARS2 | TRIAP1 | 0.716647 | 4 | 0 | 4 |
| LARS2 | CHID1 | 0.71515 | 3 | 0 | 3 |
| LARS2 | WIPF2 | 0.713736 | 3 | 0 | 3 |
| LARS2 | STOML1 | 0.713088 | 3 | 0 | 3 |
| LARS2 | BAG4 | 0.712239 | 4 | 0 | 4 |
| LARS2 | CENPE | 0.711869 | 5 | 0 | 5 |
For details and further investigation, click here
