CDK4

 

Full name: cyclin dependent kinase 4 Alias Symbol: PSK-J3
Type: protein-coding gene Cytoband: 12q14.1
Entrez ID: 1019 HGNC ID: HGNC:1773 Ensembl Gene: ENSG00000135446 OMIM ID: 123829
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 84/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CDK4 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04530Tight junction
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05214Glioma
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer

 

Expression of CDK4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDK4 1019 202246_s_at 0.9705 0.0652
GSE20347 CDK4 1019 202246_s_at 1.2624 0.0000
GSE23400 CDK4 1019 202246_s_at 1.1131 0.0000
GSE26886 CDK4 1019 202246_s_at 0.9462 0.0001
GSE29001 CDK4 1019 202246_s_at 1.0176 0.0106
GSE38129 CDK4 1019 202246_s_at 1.4995 0.0000
GSE45670 CDK4 1019 202246_s_at 0.6189 0.0034
GSE53622 CDK4 1019 71842 0.9593 0.0000
GSE53624 CDK4 1019 71842 1.2408 0.0000
GSE63941 CDK4 1019 202246_s_at 1.1555 0.0042
GSE77861 CDK4 1019 202246_s_at 0.9977 0.0016
GSE97050 CDK4 1019 A_23_P24997 0.6572 0.1726
SRP007169 CDK4 1019 RNAseq 1.3201 0.0007
SRP008496 CDK4 1019 RNAseq 1.2465 0.0000
SRP064894 CDK4 1019 RNAseq 1.0507 0.0000
SRP133303 CDK4 1019 RNAseq 0.9878 0.0000
SRP159526 CDK4 1019 RNAseq 1.1395 0.0000
SRP193095 CDK4 1019 RNAseq 0.7803 0.0000
SRP219564 CDK4 1019 RNAseq 0.8518 0.0437
TCGA CDK4 1019 RNAseq 0.3430 0.0000

Upregulated datasets: 10; Downregulated datasets: 0.  

 

Survival by CDK4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDK4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDK4 1019 7 1 22
GSE20123 CDK4 1019 7 0 23
GSE43470 CDK4 1019 2 0 41
GSE46452 CDK4 1019 8 1 50
GSE47630 CDK4 1019 10 2 28
GSE54993 CDK4 1019 0 5 65
GSE54994 CDK4 1019 4 1 48
GSE60625 CDK4 1019 0 0 11
GSE74703 CDK4 1019 2 0 34
GSE74704 CDK4 1019 5 0 15
TCGA CDK4 1019 14 10 72

Total number of gains: 59; Total number of losses: 20; Total Number of normals: 409.  

 

Somatic mutations of CDK4:

 

Generating mutation plots.

 

Highly correlated genes for CDK4:

 

Showing top 20/2158 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDK4MCM20.79567112012
CDK4RAD180.789198303
CDK4MCM70.78353812011
CDK4RFC40.77548113012
CDK4UBE2T0.769794909
CDK4CKS1B0.76346813012
CDK4TXNDC120.762153707
CDK4RUVBL10.75841113011
CDK4RNASEH2A0.75376513012
CDK4DNMT10.75166812011
CDK4SNRPB0.74817510010
CDK4SNRPE0.74350812012
CDK4NUP930.74342610010
CDK4ZBTB90.741716404
CDK4RAB340.741294303
CDK4MCM60.73922613012
CDK4NOP560.738956303
CDK4DSCC10.73846410010
CDK4PSMC20.7377410010
CDK4LSM40.73714611011

For details and further investigation, click here