| Full name: leucine rich repeat containing 8 VRAC subunit B | Alias Symbol: TA-LRRP|KIAA0231 | ||
| Type: protein-coding gene | Cytoband: 1p22.2 | ||
| Entrez ID: 23507 | HGNC ID: HGNC:30692 | Ensembl Gene: ENSG00000197147 | OMIM ID: 612888 |
| Drug and gene relationship at DGIdb | |||
Expression of LRRC8B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRC8B | 23507 | 212978_at | 1.0259 | 0.1004 | |
| GSE20347 | LRRC8B | 23507 | 212978_at | 0.0008 | 0.9973 | |
| GSE23400 | LRRC8B | 23507 | 212978_at | 0.2543 | 0.0120 | |
| GSE26886 | LRRC8B | 23507 | 212978_at | 0.6895 | 0.0098 | |
| GSE29001 | LRRC8B | 23507 | 212978_at | 0.2635 | 0.4469 | |
| GSE38129 | LRRC8B | 23507 | 212978_at | 0.3156 | 0.0648 | |
| GSE45670 | LRRC8B | 23507 | 212978_at | 0.4252 | 0.0096 | |
| GSE53622 | LRRC8B | 23507 | 95684 | 0.5477 | 0.0000 | |
| GSE53624 | LRRC8B | 23507 | 95684 | 0.3387 | 0.0051 | |
| GSE63941 | LRRC8B | 23507 | 212978_at | 1.2886 | 0.0848 | |
| GSE77861 | LRRC8B | 23507 | 212978_at | 0.3066 | 0.2150 | |
| GSE97050 | LRRC8B | 23507 | A_23_P115167 | 0.5878 | 0.0828 | |
| SRP007169 | LRRC8B | 23507 | RNAseq | 1.1646 | 0.0111 | |
| SRP008496 | LRRC8B | 23507 | RNAseq | 0.9106 | 0.0021 | |
| SRP064894 | LRRC8B | 23507 | RNAseq | 0.2301 | 0.3779 | |
| SRP133303 | LRRC8B | 23507 | RNAseq | 0.6828 | 0.0051 | |
| SRP159526 | LRRC8B | 23507 | RNAseq | 0.3451 | 0.3211 | |
| SRP193095 | LRRC8B | 23507 | RNAseq | 0.4105 | 0.0113 | |
| SRP219564 | LRRC8B | 23507 | RNAseq | 0.1720 | 0.7136 | |
| TCGA | LRRC8B | 23507 | RNAseq | 0.0565 | 0.4369 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by LRRC8B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRC8B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC8B | 23507 | 0 | 7 | 23 | |
| GSE20123 | LRRC8B | 23507 | 0 | 7 | 23 | |
| GSE43470 | LRRC8B | 23507 | 2 | 3 | 38 | |
| GSE46452 | LRRC8B | 23507 | 1 | 1 | 57 | |
| GSE47630 | LRRC8B | 23507 | 8 | 5 | 27 | |
| GSE54993 | LRRC8B | 23507 | 0 | 1 | 69 | |
| GSE54994 | LRRC8B | 23507 | 6 | 2 | 45 | |
| GSE60625 | LRRC8B | 23507 | 0 | 0 | 11 | |
| GSE74703 | LRRC8B | 23507 | 1 | 3 | 32 | |
| GSE74704 | LRRC8B | 23507 | 0 | 5 | 15 | |
| TCGA | LRRC8B | 23507 | 6 | 23 | 67 |
Total number of gains: 24; Total number of losses: 57; Total Number of normals: 407.
Somatic mutations of LRRC8B:
Generating mutation plots.
Highly correlated genes for LRRC8B:
Showing top 20/841 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC8B | DDX28 | 0.75738 | 4 | 0 | 4 |
| LRRC8B | TTLL4 | 0.756799 | 3 | 0 | 3 |
| LRRC8B | POLA1 | 0.751344 | 3 | 0 | 3 |
| LRRC8B | EMG1 | 0.746809 | 4 | 0 | 3 |
| LRRC8B | ETV6 | 0.732179 | 3 | 0 | 3 |
| LRRC8B | TRIM28 | 0.729172 | 3 | 0 | 3 |
| LRRC8B | ZNF417 | 0.727847 | 3 | 0 | 3 |
| LRRC8B | SENP1 | 0.727115 | 3 | 0 | 3 |
| LRRC8B | SMC1A | 0.71801 | 3 | 0 | 3 |
| LRRC8B | COQ4 | 0.712434 | 3 | 0 | 3 |
| LRRC8B | TAS2R19 | 0.708925 | 3 | 0 | 3 |
| LRRC8B | IFIT5 | 0.707765 | 3 | 0 | 3 |
| LRRC8B | CDYL | 0.707332 | 3 | 0 | 3 |
| LRRC8B | GPR19 | 0.705229 | 3 | 0 | 3 |
| LRRC8B | PPP5C | 0.704316 | 4 | 0 | 4 |
| LRRC8B | NCAPD2 | 0.704219 | 5 | 0 | 4 |
| LRRC8B | PSMD7 | 0.703458 | 3 | 0 | 3 |
| LRRC8B | ORC3 | 0.702718 | 3 | 0 | 3 |
| LRRC8B | FAM110A | 0.700067 | 3 | 0 | 3 |
| LRRC8B | PSMD2 | 0.697445 | 5 | 0 | 5 |
For details and further investigation, click here
