CDK1

 

Full name: cyclin dependent kinase 1 Alias Symbol: CDC28A
Type: protein-coding gene Cytoband: 10q21.2
Entrez ID: 983 HGNC ID: HGNC:1722 Ensembl Gene: ENSG00000170312 OMIM ID: 116940
Drug and gene relationship at DGIdb

 

CDK1 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04115p53 signaling pathway
hsa04540Gap junction
hsa04914Progesterone-mediated oocyte maturation
hsa05168Herpes simplex infection

 

Expression of CDK1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDK1 983 203213_at 1.4738 0.0556
GSE20347 CDK1 983 203213_at 1.8968 0.0000
GSE23400 CDK1 983 210559_s_at 1.7608 0.0000
GSE26886 CDK1 983 203213_at 0.5726 0.1664
GSE29001 CDK1 983 203213_at 1.4004 0.0035
GSE38129 CDK1 983 203213_at 2.3921 0.0000
GSE45670 CDK1 983 203213_at 1.5264 0.0000
GSE53622 CDK1 983 17753 1.7571 0.0000
GSE53624 CDK1 983 17753 2.0468 0.0000
GSE63941 CDK1 983 203213_at 3.4172 0.0001
GSE77861 CDK1 983 203213_at 1.0944 0.0661
GSE97050 CDK1 983 A_23_P138507 1.3228 0.1413
SRP007169 CDK1 983 RNAseq 1.6785 0.0027
SRP008496 CDK1 983 RNAseq 1.3564 0.0002
SRP064894 CDK1 983 RNAseq 1.1971 0.0001
SRP133303 CDK1 983 RNAseq 1.8425 0.0000
SRP159526 CDK1 983 RNAseq 0.7186 0.0219
SRP193095 CDK1 983 RNAseq 0.7957 0.0000
SRP219564 CDK1 983 RNAseq 1.2407 0.1057
TCGA CDK1 983 RNAseq 0.9898 0.0000

Upregulated datasets: 12; Downregulated datasets: 0.  

 

Survival by CDK1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDK1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDK1 983 2 7 21
GSE20123 CDK1 983 2 7 21
GSE43470 CDK1 983 2 5 36
GSE46452 CDK1 983 0 11 48
GSE47630 CDK1 983 4 12 24
GSE54993 CDK1 983 9 0 61
GSE54994 CDK1 983 2 10 41
GSE60625 CDK1 983 0 0 11
GSE74703 CDK1 983 2 3 31
GSE74704 CDK1 983 1 5 14
TCGA CDK1 983 11 23 62

Total number of gains: 35; Total number of losses: 83; Total Number of normals: 370.  

 

Somatic mutations of CDK1:

 

Generating mutation plots.

 

Highly correlated genes for CDK1:

 

Showing top 20/1847 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDK1CEP550.88576212012
CDK1RAD51AP10.88540412012
CDK1ECT20.86963312012
CDK1KIF2C0.86379112012
CDK1DLGAP50.86131212012
CDK1MAD2L10.85819912012
CDK1STIL0.85815412012
CDK1NEK20.85798512012
CDK1CCNA20.85581712012
CDK1KIF110.85385112012
CDK1CENPF0.85344612012
CDK1BUB1B0.84859610010
CDK1TTK0.84794812012
CDK1KIF4A0.84729111011
CDK1NUSAP10.84689912012
CDK1KIF140.84541912012
CDK1FOXM10.84323412012
CDK1TPX20.84215812012
CDK1ATAD20.84159812012
CDK1PBK0.84054712012

For details and further investigation, click here