RMI1

 

Full name: RecQ mediated genome instability 1 Alias Symbol: FLJ12888|BLAP75
Type: protein-coding gene Cytoband: 9q21.32
Entrez ID: 80010 HGNC ID: HGNC:25764 Ensembl Gene: ENSG00000178966 OMIM ID: 610404
Drug and gene relationship at DGIdb
Screen Evidence:

 

RMI1 involved pathways:

KEGG pathway Description View
hsa03460Fanconi anemia pathway

 

Expression of RMI1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RMI1 80010 218979_at 0.6322 0.0794
GSE20347 RMI1 80010 218979_at 0.7559 0.0000
GSE23400 RMI1 80010 218979_at 0.6445 0.0000
GSE26886 RMI1 80010 218979_at 0.3208 0.1495
GSE29001 RMI1 80010 218979_at 0.9949 0.0050
GSE38129 RMI1 80010 218979_at 0.9671 0.0000
GSE45670 RMI1 80010 218979_at 0.5854 0.0015
GSE53622 RMI1 80010 104695 0.4671 0.0000
GSE53624 RMI1 80010 104695 0.7825 0.0000
GSE63941 RMI1 80010 218979_at 1.3583 0.0037
GSE77861 RMI1 80010 218979_at 0.5178 0.0690
GSE97050 RMI1 80010 A_23_P112341 0.4388 0.2092
SRP007169 RMI1 80010 RNAseq 0.7188 0.0948
SRP008496 RMI1 80010 RNAseq 0.9530 0.0011
SRP064894 RMI1 80010 RNAseq 0.6447 0.0165
SRP133303 RMI1 80010 RNAseq 0.7538 0.0000
SRP159526 RMI1 80010 RNAseq 0.4553 0.1079
SRP193095 RMI1 80010 RNAseq 0.1737 0.2717
SRP219564 RMI1 80010 RNAseq 0.7272 0.0469
TCGA RMI1 80010 RNAseq 0.1853 0.0090

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by RMI1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RMI1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RMI1 80010 5 10 15
GSE20123 RMI1 80010 5 10 15
GSE43470 RMI1 80010 6 3 34
GSE46452 RMI1 80010 6 14 39
GSE47630 RMI1 80010 1 18 21
GSE54993 RMI1 80010 4 2 64
GSE54994 RMI1 80010 6 12 35
GSE60625 RMI1 80010 0 0 11
GSE74703 RMI1 80010 5 3 28
GSE74704 RMI1 80010 3 7 10
TCGA RMI1 80010 20 28 48

Total number of gains: 61; Total number of losses: 107; Total Number of normals: 320.  

 

Somatic mutations of RMI1:

 

Generating mutation plots.

 

Highly correlated genes for RMI1:

 

Showing top 20/1481 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RMI1RACGAP10.77932510010
RMI1CDCA20.776217606
RMI1MCM60.74994613013
RMI1DTL0.74882813012
RMI1GINS10.74594112011
RMI1ATAD20.74487212012
RMI1ECT20.74266612011
RMI1SMC20.74201413012
RMI1CDK10.74073212012
RMI1TOP2A0.7398813013
RMI1TTK0.73964912012
RMI1ASPM0.73878213013
RMI1NEK20.73591713013
RMI1NUSAP10.73553113013
RMI1TIMELESS0.73177112012
RMI1REL0.729734404
RMI1AP1S30.72785303
RMI1RFC40.72676113013
RMI1SKA30.726625707
RMI1TPX20.72413312012

For details and further investigation, click here