| Full name: SMG8 nonsense mediated mRNA decay factor | Alias Symbol: FLJ10587|FLJ23205 | ||
| Type: protein-coding gene | Cytoband: 17q23.2 | ||
| Entrez ID: 55181 | HGNC ID: HGNC:25551 | Ensembl Gene: ENSG00000167447 | OMIM ID: 613175 |
Expression of SMG8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMG8 | 55181 | 218514_at | 0.1686 | 0.7096 | |
| GSE20347 | SMG8 | 55181 | 218514_at | 0.1947 | 0.2829 | |
| GSE23400 | SMG8 | 55181 | 218514_at | 0.2613 | 0.0000 | |
| GSE26886 | SMG8 | 55181 | 218514_at | -0.2026 | 0.4054 | |
| GSE29001 | SMG8 | 55181 | 218514_at | 0.2267 | 0.2620 | |
| GSE38129 | SMG8 | 55181 | 218514_at | 0.3021 | 0.0116 | |
| GSE45670 | SMG8 | 55181 | 218514_at | 0.2679 | 0.0516 | |
| GSE53622 | SMG8 | 55181 | 56621 | 0.3699 | 0.0000 | |
| GSE53624 | SMG8 | 55181 | 56621 | 0.3821 | 0.0000 | |
| GSE63941 | SMG8 | 55181 | 218514_at | -0.2984 | 0.3394 | |
| GSE77861 | SMG8 | 55181 | 218514_at | 0.2859 | 0.2017 | |
| GSE97050 | SMG8 | 55181 | A_23_P66563 | 0.2563 | 0.2827 | |
| SRP007169 | SMG8 | 55181 | RNAseq | 0.6940 | 0.1281 | |
| SRP008496 | SMG8 | 55181 | RNAseq | 0.7259 | 0.0317 | |
| SRP064894 | SMG8 | 55181 | RNAseq | 0.2643 | 0.1831 | |
| SRP133303 | SMG8 | 55181 | RNAseq | 0.5640 | 0.0021 | |
| SRP159526 | SMG8 | 55181 | RNAseq | 0.2592 | 0.1755 | |
| SRP193095 | SMG8 | 55181 | RNAseq | 0.0981 | 0.3048 | |
| SRP219564 | SMG8 | 55181 | RNAseq | 0.2522 | 0.3652 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SMG8 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SMG8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMG8 | 55181 | 6 | 1 | 23 | |
| GSE20123 | SMG8 | 55181 | 6 | 1 | 23 | |
| GSE43470 | SMG8 | 55181 | 3 | 0 | 40 | |
| GSE46452 | SMG8 | 55181 | 32 | 0 | 27 | |
| GSE47630 | SMG8 | 55181 | 7 | 1 | 32 | |
| GSE54993 | SMG8 | 55181 | 2 | 5 | 63 | |
| GSE54994 | SMG8 | 55181 | 9 | 5 | 39 | |
| GSE60625 | SMG8 | 55181 | 4 | 0 | 7 | |
| GSE74703 | SMG8 | 55181 | 3 | 0 | 33 | |
| GSE74704 | SMG8 | 55181 | 5 | 1 | 14 | |
| TCGA | SMG8 | 55181 | 26 | 7 | 63 |
Total number of gains: 103; Total number of losses: 21; Total Number of normals: 364.
Somatic mutations of SMG8:
Generating mutation plots.
Highly correlated genes for SMG8:
Showing top 20/899 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMG8 | KTI12 | 0.780329 | 3 | 0 | 3 |
| SMG8 | RLIM | 0.758822 | 3 | 0 | 3 |
| SMG8 | ARL13B | 0.746294 | 3 | 0 | 3 |
| SMG8 | TTC39C | 0.742552 | 3 | 0 | 3 |
| SMG8 | SNX30 | 0.74121 | 4 | 0 | 3 |
| SMG8 | GPR34 | 0.727019 | 3 | 0 | 3 |
| SMG8 | USP38 | 0.72398 | 4 | 0 | 3 |
| SMG8 | ARFGEF2 | 0.722314 | 3 | 0 | 3 |
| SMG8 | APIP | 0.714302 | 3 | 0 | 3 |
| SMG8 | ARHGAP18 | 0.709897 | 4 | 0 | 4 |
| SMG8 | ASH2L | 0.709402 | 5 | 0 | 4 |
| SMG8 | GPR65 | 0.708599 | 3 | 0 | 3 |
| SMG8 | UBB | 0.708364 | 4 | 0 | 4 |
| SMG8 | SLC35B1 | 0.708121 | 11 | 0 | 11 |
| SMG8 | SRFBP1 | 0.706957 | 3 | 0 | 3 |
| SMG8 | CWF19L2 | 0.704711 | 3 | 0 | 3 |
| SMG8 | MRPS23 | 0.702409 | 6 | 0 | 6 |
| SMG8 | SWT1 | 0.701096 | 3 | 0 | 3 |
| SMG8 | MMS22L | 0.699285 | 3 | 0 | 3 |
| SMG8 | E4F1 | 0.698627 | 3 | 0 | 3 |
For details and further investigation, click here
