| Full name: sphingomyelin phosphodiesterase acid like 3B | Alias Symbol: ASML3B | ||
| Type: protein-coding gene | Cytoband: 1p35.3 | ||
| Entrez ID: 27293 | HGNC ID: HGNC:21416 | Ensembl Gene: ENSG00000130768 | OMIM ID: 617737 |
| Drug and gene relationship at DGIdb | |||
Expression of SMPDL3B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMPDL3B | 27293 | 1554050_at | 0.0352 | 0.9309 | |
| GSE20347 | SMPDL3B | 27293 | 205309_at | -0.0818 | 0.2290 | |
| GSE23400 | SMPDL3B | 27293 | 205309_at | -0.0716 | 0.0648 | |
| GSE26886 | SMPDL3B | 27293 | 1554050_at | 0.2484 | 0.0486 | |
| GSE29001 | SMPDL3B | 27293 | 205309_at | -0.1792 | 0.1087 | |
| GSE38129 | SMPDL3B | 27293 | 205309_at | 0.0035 | 0.9732 | |
| GSE45670 | SMPDL3B | 27293 | 1554050_at | 0.2548 | 0.0064 | |
| GSE53622 | SMPDL3B | 27293 | 40239 | 0.5764 | 0.0000 | |
| GSE53624 | SMPDL3B | 27293 | 40239 | 0.0305 | 0.8126 | |
| GSE63941 | SMPDL3B | 27293 | 1554050_at | 0.2937 | 0.1768 | |
| GSE77861 | SMPDL3B | 27293 | 1554050_at | 0.0708 | 0.6093 | |
| GSE97050 | SMPDL3B | 27293 | A_23_P160881 | 0.5829 | 0.1534 | |
| SRP133303 | SMPDL3B | 27293 | RNAseq | 0.6813 | 0.0807 | |
| SRP159526 | SMPDL3B | 27293 | RNAseq | 1.3396 | 0.0379 | |
| TCGA | SMPDL3B | 27293 | RNAseq | -1.0216 | 0.0074 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by SMPDL3B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMPDL3B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMPDL3B | 27293 | 0 | 6 | 24 | |
| GSE20123 | SMPDL3B | 27293 | 0 | 5 | 25 | |
| GSE43470 | SMPDL3B | 27293 | 3 | 6 | 34 | |
| GSE46452 | SMPDL3B | 27293 | 5 | 1 | 53 | |
| GSE47630 | SMPDL3B | 27293 | 8 | 3 | 29 | |
| GSE54993 | SMPDL3B | 27293 | 2 | 1 | 67 | |
| GSE54994 | SMPDL3B | 27293 | 10 | 4 | 39 | |
| GSE60625 | SMPDL3B | 27293 | 0 | 0 | 11 | |
| GSE74703 | SMPDL3B | 27293 | 2 | 4 | 30 | |
| GSE74704 | SMPDL3B | 27293 | 0 | 0 | 20 | |
| TCGA | SMPDL3B | 27293 | 11 | 23 | 62 |
Total number of gains: 41; Total number of losses: 53; Total Number of normals: 394.
Somatic mutations of SMPDL3B:
Generating mutation plots.
Highly correlated genes for SMPDL3B:
Showing top 20/153 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMPDL3B | LCN10 | 0.724532 | 3 | 0 | 3 |
| SMPDL3B | NPHP4 | 0.715935 | 3 | 0 | 3 |
| SMPDL3B | C17orf67 | 0.703241 | 3 | 0 | 3 |
| SMPDL3B | CCDC151 | 0.690133 | 3 | 0 | 3 |
| SMPDL3B | GGN | 0.664605 | 3 | 0 | 3 |
| SMPDL3B | CD22 | 0.664297 | 3 | 0 | 3 |
| SMPDL3B | TMC6 | 0.659313 | 3 | 0 | 3 |
| SMPDL3B | VWA3A | 0.65929 | 3 | 0 | 3 |
| SMPDL3B | RRBP1 | 0.651653 | 3 | 0 | 3 |
| SMPDL3B | AK8 | 0.646333 | 4 | 0 | 4 |
| SMPDL3B | ARHGEF16 | 0.635501 | 4 | 0 | 4 |
| SMPDL3B | TRAPPC1 | 0.635317 | 4 | 0 | 3 |
| SMPDL3B | LINC00642 | 0.634524 | 5 | 0 | 3 |
| SMPDL3B | CYP2A13 | 0.634158 | 3 | 0 | 3 |
| SMPDL3B | GIGYF1 | 0.632134 | 4 | 0 | 3 |
| SMPDL3B | ATN1 | 0.628835 | 3 | 0 | 3 |
| SMPDL3B | STARD3 | 0.628729 | 3 | 0 | 3 |
| SMPDL3B | HOXD8 | 0.626893 | 4 | 0 | 3 |
| SMPDL3B | CDK2AP2 | 0.624503 | 4 | 0 | 4 |
| SMPDL3B | TTLL10 | 0.623515 | 4 | 0 | 3 |
For details and further investigation, click here
