| Full name: nephrocystin 4 | Alias Symbol: SLSN4|KIAA0673|POC10 | ||
| Type: protein-coding gene | Cytoband: 1p36.31 | ||
| Entrez ID: 261734 | HGNC ID: HGNC:19104 | Ensembl Gene: ENSG00000131697 | OMIM ID: 607215 |
| Drug and gene relationship at DGIdb | |||
Expression of NPHP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPHP4 | 261734 | 213471_at | 0.7156 | 0.0985 | |
| GSE20347 | NPHP4 | 261734 | 216344_at | -0.0650 | 0.3485 | |
| GSE23400 | NPHP4 | 261734 | 213471_at | 0.2141 | 0.0000 | |
| GSE26886 | NPHP4 | 261734 | 213471_at | 1.0281 | 0.0000 | |
| GSE29001 | NPHP4 | 261734 | 213471_at | 0.4551 | 0.0124 | |
| GSE38129 | NPHP4 | 261734 | 216344_at | -0.1213 | 0.1364 | |
| GSE45670 | NPHP4 | 261734 | 213471_at | 0.2516 | 0.0605 | |
| GSE53622 | NPHP4 | 261734 | 50878 | 0.6554 | 0.0000 | |
| GSE53624 | NPHP4 | 261734 | 29363 | 0.7702 | 0.0000 | |
| GSE63941 | NPHP4 | 261734 | 213471_at | 0.0266 | 0.9618 | |
| GSE77861 | NPHP4 | 261734 | 213471_at | 0.1100 | 0.6277 | |
| GSE97050 | NPHP4 | 261734 | A_33_P3372389 | 0.4283 | 0.1512 | |
| SRP007169 | NPHP4 | 261734 | RNAseq | 1.0515 | 0.0642 | |
| SRP008496 | NPHP4 | 261734 | RNAseq | 1.0402 | 0.0196 | |
| SRP064894 | NPHP4 | 261734 | RNAseq | 0.8393 | 0.0000 | |
| SRP133303 | NPHP4 | 261734 | RNAseq | 0.5304 | 0.0012 | |
| SRP159526 | NPHP4 | 261734 | RNAseq | 0.8183 | 0.0200 | |
| SRP193095 | NPHP4 | 261734 | RNAseq | 0.7825 | 0.0000 | |
| SRP219564 | NPHP4 | 261734 | RNAseq | 0.4465 | 0.0563 | |
| TCGA | NPHP4 | 261734 | RNAseq | 0.2089 | 0.0006 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NPHP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPHP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPHP4 | 261734 | 3 | 6 | 21 | |
| GSE20123 | NPHP4 | 261734 | 3 | 5 | 22 | |
| GSE43470 | NPHP4 | 261734 | 6 | 5 | 32 | |
| GSE46452 | NPHP4 | 261734 | 7 | 1 | 51 | |
| GSE47630 | NPHP4 | 261734 | 8 | 4 | 28 | |
| GSE54993 | NPHP4 | 261734 | 3 | 2 | 65 | |
| GSE54994 | NPHP4 | 261734 | 14 | 3 | 36 | |
| GSE60625 | NPHP4 | 261734 | 0 | 0 | 11 | |
| GSE74703 | NPHP4 | 261734 | 5 | 3 | 28 | |
| GSE74704 | NPHP4 | 261734 | 3 | 0 | 17 | |
| TCGA | NPHP4 | 261734 | 12 | 22 | 62 |
Total number of gains: 64; Total number of losses: 51; Total Number of normals: 373.
Somatic mutations of NPHP4:
Generating mutation plots.
Highly correlated genes for NPHP4:
Showing top 20/836 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPHP4 | TDRKH | 0.763518 | 3 | 0 | 3 |
| NPHP4 | DPP7 | 0.749357 | 3 | 0 | 3 |
| NPHP4 | SLC39A10 | 0.743241 | 5 | 0 | 5 |
| NPHP4 | ROMO1 | 0.741857 | 3 | 0 | 3 |
| NPHP4 | ZBTB9 | 0.722605 | 5 | 0 | 5 |
| NPHP4 | SMPDL3B | 0.715935 | 3 | 0 | 3 |
| NPHP4 | MRPL14 | 0.713491 | 4 | 0 | 4 |
| NPHP4 | UBE2J2 | 0.711146 | 5 | 0 | 5 |
| NPHP4 | SERPINF2 | 0.701931 | 3 | 0 | 3 |
| NPHP4 | CNTROB | 0.700113 | 5 | 0 | 5 |
| NPHP4 | CCDC150 | 0.698555 | 4 | 0 | 4 |
| NPHP4 | TNK1 | 0.690696 | 5 | 0 | 5 |
| NPHP4 | LRIG2 | 0.685354 | 3 | 0 | 3 |
| NPHP4 | AP2A1 | 0.683848 | 3 | 0 | 3 |
| NPHP4 | CPNE2 | 0.68362 | 5 | 0 | 5 |
| NPHP4 | FAM89A | 0.682397 | 3 | 0 | 3 |
| NPHP4 | ALG1 | 0.682376 | 3 | 0 | 3 |
| NPHP4 | YDJC | 0.681596 | 5 | 0 | 4 |
| NPHP4 | GZMB | 0.681267 | 3 | 0 | 3 |
| NPHP4 | DHRS13 | 0.678899 | 3 | 0 | 3 |
For details and further investigation, click here
