| Full name: sterol O-acyltransferase 1 | Alias Symbol: ACAT | ||
| Type: protein-coding gene | Cytoband: 1q25.2 | ||
| Entrez ID: 6646 | HGNC ID: HGNC:11177 | Ensembl Gene: ENSG00000057252 | OMIM ID: 102642 |
| Drug and gene relationship at DGIdb | |||
Expression of SOAT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOAT1 | 6646 | 228479_at | 0.5818 | 0.1651 | |
| GSE20347 | SOAT1 | 6646 | 221561_at | 1.2466 | 0.0001 | |
| GSE23400 | SOAT1 | 6646 | 221561_at | 0.5972 | 0.0000 | |
| GSE26886 | SOAT1 | 6646 | 228479_at | 1.5751 | 0.0000 | |
| GSE29001 | SOAT1 | 6646 | 221561_at | 2.1248 | 0.0000 | |
| GSE38129 | SOAT1 | 6646 | 221561_at | 1.4298 | 0.0000 | |
| GSE45670 | SOAT1 | 6646 | 228479_at | -0.3023 | 0.2947 | |
| GSE53622 | SOAT1 | 6646 | 28829 | 0.3774 | 0.0010 | |
| GSE53624 | SOAT1 | 6646 | 28829 | 1.1045 | 0.0000 | |
| GSE63941 | SOAT1 | 6646 | 221561_at | -1.1756 | 0.0129 | |
| GSE77861 | SOAT1 | 6646 | 228479_at | 0.6977 | 0.0493 | |
| GSE97050 | SOAT1 | 6646 | A_24_P216654 | 0.6269 | 0.1126 | |
| SRP007169 | SOAT1 | 6646 | RNAseq | 2.9051 | 0.0000 | |
| SRP008496 | SOAT1 | 6646 | RNAseq | 2.5205 | 0.0000 | |
| SRP064894 | SOAT1 | 6646 | RNAseq | 1.3475 | 0.0000 | |
| SRP133303 | SOAT1 | 6646 | RNAseq | 1.0274 | 0.0000 | |
| SRP159526 | SOAT1 | 6646 | RNAseq | 1.3390 | 0.0000 | |
| SRP193095 | SOAT1 | 6646 | RNAseq | 0.8147 | 0.0000 | |
| SRP219564 | SOAT1 | 6646 | RNAseq | 1.5096 | 0.0017 | |
| TCGA | SOAT1 | 6646 | RNAseq | -0.0232 | 0.7537 |
Upregulated datasets: 11; Downregulated datasets: 1.
Survival by SOAT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOAT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOAT1 | 6646 | 12 | 0 | 18 | |
| GSE20123 | SOAT1 | 6646 | 12 | 0 | 18 | |
| GSE43470 | SOAT1 | 6646 | 7 | 1 | 35 | |
| GSE46452 | SOAT1 | 6646 | 3 | 1 | 55 | |
| GSE47630 | SOAT1 | 6646 | 14 | 0 | 26 | |
| GSE54993 | SOAT1 | 6646 | 0 | 6 | 64 | |
| GSE54994 | SOAT1 | 6646 | 15 | 0 | 38 | |
| GSE60625 | SOAT1 | 6646 | 0 | 0 | 11 | |
| GSE74703 | SOAT1 | 6646 | 7 | 1 | 28 | |
| GSE74704 | SOAT1 | 6646 | 5 | 0 | 15 | |
| TCGA | SOAT1 | 6646 | 40 | 3 | 53 |
Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.
Somatic mutations of SOAT1:
Generating mutation plots.
Highly correlated genes for SOAT1:
Showing top 20/1678 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOAT1 | DGKH | 0.782218 | 3 | 0 | 3 |
| SOAT1 | KRTCAP2 | 0.757655 | 3 | 0 | 3 |
| SOAT1 | TMEM263 | 0.757635 | 7 | 0 | 7 |
| SOAT1 | ALKBH6 | 0.754714 | 3 | 0 | 3 |
| SOAT1 | PSMB2 | 0.737894 | 8 | 0 | 8 |
| SOAT1 | CEP78 | 0.737555 | 5 | 0 | 5 |
| SOAT1 | FCGR3A | 0.734658 | 3 | 0 | 3 |
| SOAT1 | A1BG | 0.734347 | 3 | 0 | 3 |
| SOAT1 | SAFB2 | 0.732631 | 3 | 0 | 3 |
| SOAT1 | LHFPL2 | 0.727964 | 12 | 0 | 12 |
| SOAT1 | SSBP4 | 0.723675 | 4 | 0 | 4 |
| SOAT1 | MRPS23 | 0.719849 | 4 | 0 | 4 |
| SOAT1 | TAF1A | 0.717927 | 7 | 0 | 7 |
| SOAT1 | PRPS1 | 0.715928 | 11 | 0 | 10 |
| SOAT1 | ACTA2 | 0.712954 | 4 | 0 | 3 |
| SOAT1 | TMEM47 | 0.710881 | 4 | 0 | 4 |
| SOAT1 | FHL3 | 0.709887 | 5 | 0 | 4 |
| SOAT1 | PLOD1 | 0.708671 | 11 | 0 | 10 |
| SOAT1 | SLC39A14 | 0.707183 | 11 | 0 | 10 |
| SOAT1 | ARPC1B | 0.706208 | 10 | 0 | 9 |
For details and further investigation, click here
