| Full name: SRY-box transcription factor 18 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20q13.33 | ||
| Entrez ID: 54345 | HGNC ID: HGNC:11194 | Ensembl Gene: ENSG00000203883 | OMIM ID: 601618 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SOX18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOX18 | 54345 | 219568_x_at | 0.4443 | 0.3306 | |
| GSE20347 | SOX18 | 54345 | 219568_x_at | 0.0141 | 0.9230 | |
| GSE23400 | SOX18 | 54345 | 219568_x_at | -0.0131 | 0.6648 | |
| GSE26886 | SOX18 | 54345 | 219568_x_at | 0.1707 | 0.0329 | |
| GSE29001 | SOX18 | 54345 | 219568_x_at | 0.0667 | 0.4946 | |
| GSE38129 | SOX18 | 54345 | 219568_x_at | -0.1234 | 0.5099 | |
| GSE45670 | SOX18 | 54345 | 219568_x_at | 0.0281 | 0.8191 | |
| GSE53622 | SOX18 | 54345 | 48909 | -0.7532 | 0.0026 | |
| GSE53624 | SOX18 | 54345 | 48909 | -0.0799 | 0.6354 | |
| GSE63941 | SOX18 | 54345 | 219568_x_at | 0.2166 | 0.2086 | |
| GSE77861 | SOX18 | 54345 | 219568_x_at | 0.0522 | 0.5480 | |
| GSE97050 | SOX18 | 54345 | A_33_P3226761 | 0.3849 | 0.3249 | |
| SRP007169 | SOX18 | 54345 | RNAseq | 0.5212 | 0.4960 | |
| SRP064894 | SOX18 | 54345 | RNAseq | 0.6485 | 0.0646 | |
| SRP133303 | SOX18 | 54345 | RNAseq | -0.8541 | 0.0074 | |
| SRP159526 | SOX18 | 54345 | RNAseq | 0.0561 | 0.8646 | |
| TCGA | SOX18 | 54345 | RNAseq | -0.0584 | 0.5880 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SOX18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOX18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOX18 | 54345 | 13 | 2 | 15 | |
| GSE20123 | SOX18 | 54345 | 13 | 2 | 15 | |
| GSE43470 | SOX18 | 54345 | 11 | 1 | 31 | |
| GSE46452 | SOX18 | 54345 | 35 | 0 | 24 | |
| GSE47630 | SOX18 | 54345 | 25 | 1 | 14 | |
| GSE54993 | SOX18 | 54345 | 0 | 17 | 53 | |
| GSE54994 | SOX18 | 54345 | 29 | 0 | 24 | |
| GSE60625 | SOX18 | 54345 | 0 | 0 | 11 | |
| GSE74703 | SOX18 | 54345 | 10 | 0 | 26 | |
| GSE74704 | SOX18 | 54345 | 10 | 0 | 10 | |
| TCGA | SOX18 | 54345 | 44 | 4 | 48 |
Total number of gains: 190; Total number of losses: 27; Total Number of normals: 271.
Somatic mutations of SOX18:
Generating mutation plots.
Highly correlated genes for SOX18:
Showing top 20/298 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOX18 | POLDIP3 | 0.768494 | 3 | 0 | 3 |
| SOX18 | TBC1D2B | 0.765549 | 3 | 0 | 3 |
| SOX18 | TEAD2 | 0.765399 | 3 | 0 | 3 |
| SOX18 | TMPRSS3 | 0.763777 | 3 | 0 | 3 |
| SOX18 | APOL3 | 0.739224 | 3 | 0 | 3 |
| SOX18 | SSH2 | 0.73715 | 3 | 0 | 3 |
| SOX18 | MRPS14 | 0.736964 | 3 | 0 | 3 |
| SOX18 | ARHGAP9 | 0.730979 | 3 | 0 | 3 |
| SOX18 | ZNF280C | 0.727765 | 3 | 0 | 3 |
| SOX18 | CEP70 | 0.719481 | 3 | 0 | 3 |
| SOX18 | MRPS35 | 0.71913 | 3 | 0 | 3 |
| SOX18 | VASH1 | 0.718084 | 4 | 0 | 3 |
| SOX18 | BIK | 0.710918 | 3 | 0 | 3 |
| SOX18 | CXCL3 | 0.705049 | 3 | 0 | 3 |
| SOX18 | PIK3R3 | 0.70487 | 3 | 0 | 3 |
| SOX18 | FMNL3 | 0.703566 | 3 | 0 | 3 |
| SOX18 | GLCCI1 | 0.70118 | 3 | 0 | 3 |
| SOX18 | TP53I13 | 0.700085 | 4 | 0 | 4 |
| SOX18 | ZCCHC3 | 0.699879 | 3 | 0 | 3 |
| SOX18 | CKAP5 | 0.693229 | 3 | 0 | 3 |
For details and further investigation, click here
