| Full name: BCL2 interacting killer | Alias Symbol: NBK | ||
| Type: protein-coding gene | Cytoband: 22q13.2 | ||
| Entrez ID: 638 | HGNC ID: HGNC:1051 | Ensembl Gene: ENSG00000100290 | OMIM ID: 603392 |
| Drug and gene relationship at DGIdb | |||
Expression of BIK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BIK | 638 | 205780_at | 0.2150 | 0.7765 | |
| GSE20347 | BIK | 638 | 205780_at | 0.3504 | 0.2477 | |
| GSE23400 | BIK | 638 | 205780_at | 0.4853 | 0.0001 | |
| GSE26886 | BIK | 638 | 205780_at | 0.7377 | 0.0016 | |
| GSE29001 | BIK | 638 | 205780_at | -0.3925 | 0.2942 | |
| GSE38129 | BIK | 638 | 205780_at | 0.7584 | 0.0170 | |
| GSE45670 | BIK | 638 | 205780_at | 0.6123 | 0.0754 | |
| GSE53622 | BIK | 638 | 42673 | 0.5963 | 0.0260 | |
| GSE53624 | BIK | 638 | 42673 | 0.3674 | 0.0058 | |
| GSE63941 | BIK | 638 | 205780_at | 2.7956 | 0.0119 | |
| GSE77861 | BIK | 638 | 205780_at | 0.7354 | 0.0862 | |
| GSE97050 | BIK | 638 | A_23_P404667 | 0.5199 | 0.3387 | |
| SRP007169 | BIK | 638 | RNAseq | 1.0911 | 0.0409 | |
| SRP008496 | BIK | 638 | RNAseq | 0.8707 | 0.0638 | |
| SRP064894 | BIK | 638 | RNAseq | 0.1628 | 0.7254 | |
| SRP133303 | BIK | 638 | RNAseq | 0.6347 | 0.0973 | |
| SRP159526 | BIK | 638 | RNAseq | 0.3678 | 0.4275 | |
| SRP193095 | BIK | 638 | RNAseq | 0.1483 | 0.5358 | |
| SRP219564 | BIK | 638 | RNAseq | 0.9877 | 0.3732 | |
| TCGA | BIK | 638 | RNAseq | 0.4234 | 0.0294 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by BIK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BIK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BIK | 638 | 6 | 6 | 18 | |
| GSE20123 | BIK | 638 | 6 | 5 | 19 | |
| GSE43470 | BIK | 638 | 3 | 6 | 34 | |
| GSE46452 | BIK | 638 | 31 | 2 | 26 | |
| GSE47630 | BIK | 638 | 9 | 4 | 27 | |
| GSE54993 | BIK | 638 | 3 | 6 | 61 | |
| GSE54994 | BIK | 638 | 11 | 8 | 34 | |
| GSE60625 | BIK | 638 | 5 | 0 | 6 | |
| GSE74703 | BIK | 638 | 3 | 4 | 29 | |
| GSE74704 | BIK | 638 | 3 | 3 | 14 | |
| TCGA | BIK | 638 | 26 | 15 | 55 |
Total number of gains: 106; Total number of losses: 59; Total Number of normals: 323.
Somatic mutations of BIK:
Generating mutation plots.
Highly correlated genes for BIK:
Showing top 20/430 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BIK | AP1S3 | 0.765631 | 3 | 0 | 3 |
| BIK | WDR54 | 0.746226 | 3 | 0 | 3 |
| BIK | PRTFDC1 | 0.721305 | 3 | 0 | 3 |
| BIK | SOX18 | 0.710918 | 3 | 0 | 3 |
| BIK | KRTCAP2 | 0.708451 | 3 | 0 | 3 |
| BIK | CDCA7 | 0.704086 | 3 | 0 | 3 |
| BIK | USP5 | 0.703119 | 4 | 0 | 4 |
| BIK | USP21 | 0.702145 | 3 | 0 | 3 |
| BIK | RNMT | 0.693481 | 3 | 0 | 3 |
| BIK | ZNF496 | 0.693471 | 3 | 0 | 3 |
| BIK | CNKSR1 | 0.69243 | 3 | 0 | 3 |
| BIK | SCARB1 | 0.680171 | 3 | 0 | 3 |
| BIK | GPR158 | 0.674527 | 4 | 0 | 3 |
| BIK | NPRL3 | 0.672616 | 4 | 0 | 4 |
| BIK | ZNF827 | 0.668481 | 3 | 0 | 3 |
| BIK | TOP1MT | 0.66786 | 4 | 0 | 3 |
| BIK | UXT | 0.667413 | 3 | 0 | 3 |
| BIK | PRDX4 | 0.665741 | 3 | 0 | 3 |
| BIK | FUBP1 | 0.664324 | 4 | 0 | 3 |
| BIK | DYNC2H1 | 0.660691 | 3 | 0 | 3 |
For details and further investigation, click here
