| Full name: DNA polymerase delta interacting protein 3 | Alias Symbol: PDIP46|KIAA1649|SKAR|PDIP3 | ||
| Type: protein-coding gene | Cytoband: 22q13.2 | ||
| Entrez ID: 84271 | HGNC ID: HGNC:23782 | Ensembl Gene: ENSG00000100227 | OMIM ID: 611520 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of POLDIP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLDIP3 | 84271 | 212100_s_at | 0.2971 | 0.3743 | |
| GSE20347 | POLDIP3 | 84271 | 212100_s_at | 0.0600 | 0.6949 | |
| GSE23400 | POLDIP3 | 84271 | 212100_s_at | 0.0574 | 0.1593 | |
| GSE26886 | POLDIP3 | 84271 | 212100_s_at | -0.3204 | 0.0558 | |
| GSE29001 | POLDIP3 | 84271 | 212100_s_at | -0.0058 | 0.9657 | |
| GSE38129 | POLDIP3 | 84271 | 212100_s_at | -0.0735 | 0.4766 | |
| GSE45670 | POLDIP3 | 84271 | 212100_s_at | 0.0218 | 0.8991 | |
| GSE53622 | POLDIP3 | 84271 | 64923 | 0.0689 | 0.2049 | |
| GSE53624 | POLDIP3 | 84271 | 64923 | 0.2295 | 0.0000 | |
| GSE63941 | POLDIP3 | 84271 | 212100_s_at | -0.0405 | 0.9369 | |
| GSE77861 | POLDIP3 | 84271 | 212100_s_at | 0.1302 | 0.4531 | |
| GSE97050 | POLDIP3 | 84271 | A_33_P3340085 | 0.0026 | 0.9925 | |
| SRP007169 | POLDIP3 | 84271 | RNAseq | -0.7861 | 0.0356 | |
| SRP008496 | POLDIP3 | 84271 | RNAseq | -0.7618 | 0.0000 | |
| SRP064894 | POLDIP3 | 84271 | RNAseq | 0.0366 | 0.7962 | |
| SRP133303 | POLDIP3 | 84271 | RNAseq | -0.2685 | 0.0248 | |
| SRP159526 | POLDIP3 | 84271 | RNAseq | 0.0448 | 0.8220 | |
| SRP193095 | POLDIP3 | 84271 | RNAseq | -0.1971 | 0.0372 | |
| SRP219564 | POLDIP3 | 84271 | RNAseq | 0.0805 | 0.7878 | |
| TCGA | POLDIP3 | 84271 | RNAseq | -0.0927 | 0.0323 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POLDIP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLDIP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLDIP3 | 84271 | 6 | 6 | 18 | |
| GSE20123 | POLDIP3 | 84271 | 6 | 5 | 19 | |
| GSE43470 | POLDIP3 | 84271 | 4 | 6 | 33 | |
| GSE46452 | POLDIP3 | 84271 | 31 | 2 | 26 | |
| GSE47630 | POLDIP3 | 84271 | 9 | 4 | 27 | |
| GSE54993 | POLDIP3 | 84271 | 3 | 6 | 61 | |
| GSE54994 | POLDIP3 | 84271 | 11 | 8 | 34 | |
| GSE60625 | POLDIP3 | 84271 | 5 | 0 | 6 | |
| GSE74703 | POLDIP3 | 84271 | 4 | 4 | 28 | |
| GSE74704 | POLDIP3 | 84271 | 3 | 3 | 14 | |
| TCGA | POLDIP3 | 84271 | 28 | 13 | 55 |
Total number of gains: 110; Total number of losses: 57; Total Number of normals: 321.
Somatic mutations of POLDIP3:
Generating mutation plots.
Highly correlated genes for POLDIP3:
Showing top 20/242 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLDIP3 | CIAPIN1 | 0.770732 | 3 | 0 | 3 |
| POLDIP3 | SOX18 | 0.768494 | 3 | 0 | 3 |
| POLDIP3 | LRRC42 | 0.761149 | 3 | 0 | 3 |
| POLDIP3 | RBM14 | 0.760186 | 3 | 0 | 3 |
| POLDIP3 | TUFM | 0.748433 | 3 | 0 | 3 |
| POLDIP3 | GLUD1 | 0.744129 | 3 | 0 | 3 |
| POLDIP3 | MLLT6 | 0.738876 | 3 | 0 | 3 |
| POLDIP3 | AIFM1 | 0.738393 | 4 | 0 | 3 |
| POLDIP3 | LOXL4 | 0.734298 | 3 | 0 | 3 |
| POLDIP3 | SBNO1 | 0.730498 | 3 | 0 | 3 |
| POLDIP3 | ZNF784 | 0.728778 | 3 | 0 | 3 |
| POLDIP3 | ZNF564 | 0.728075 | 3 | 0 | 3 |
| POLDIP3 | FAM53B | 0.725811 | 3 | 0 | 3 |
| POLDIP3 | VPS26B | 0.72543 | 3 | 0 | 3 |
| POLDIP3 | COQ9 | 0.722285 | 3 | 0 | 3 |
| POLDIP3 | DUS3L | 0.716415 | 3 | 0 | 3 |
| POLDIP3 | TBK1 | 0.71305 | 3 | 0 | 3 |
| POLDIP3 | UNG | 0.712842 | 3 | 0 | 3 |
| POLDIP3 | ZNF606 | 0.712032 | 3 | 0 | 3 |
| POLDIP3 | ZMYM6 | 0.711524 | 3 | 0 | 3 |
For details and further investigation, click here
