| Full name: G protein-coupled receptor 3 | Alias Symbol: ACCA | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 2827 | HGNC ID: HGNC:4484 | Ensembl Gene: ENSG00000181773 | OMIM ID: 600241 |
| Drug and gene relationship at DGIdb | |||
Expression of GPR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR3 | 2827 | 214613_at | -0.1199 | 0.7194 | |
| GSE20347 | GPR3 | 2827 | 214613_at | 0.1628 | 0.1163 | |
| GSE23400 | GPR3 | 2827 | 214613_at | -0.1159 | 0.0013 | |
| GSE26886 | GPR3 | 2827 | 214613_at | 0.3111 | 0.0153 | |
| GSE29001 | GPR3 | 2827 | 214613_at | -0.1080 | 0.3467 | |
| GSE38129 | GPR3 | 2827 | 214613_at | 0.1036 | 0.3954 | |
| GSE45670 | GPR3 | 2827 | 214613_at | -0.1346 | 0.1271 | |
| GSE53622 | GPR3 | 2827 | 31370 | -0.1633 | 0.1867 | |
| GSE53624 | GPR3 | 2827 | 31370 | -0.7280 | 0.0000 | |
| GSE63941 | GPR3 | 2827 | 214613_at | 0.3283 | 0.1279 | |
| GSE77861 | GPR3 | 2827 | 214613_at | 0.0309 | 0.7545 | |
| GSE97050 | GPR3 | 2827 | A_23_P35000 | 0.0276 | 0.9169 | |
| SRP007169 | GPR3 | 2827 | RNAseq | 2.1607 | 0.0158 | |
| SRP159526 | GPR3 | 2827 | RNAseq | 2.0014 | 0.0062 | |
| SRP219564 | GPR3 | 2827 | RNAseq | -0.3946 | 0.6278 | |
| TCGA | GPR3 | 2827 | RNAseq | 0.4292 | 0.0631 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by GPR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR3 | 2827 | 0 | 6 | 24 | |
| GSE20123 | GPR3 | 2827 | 0 | 5 | 25 | |
| GSE43470 | GPR3 | 2827 | 4 | 6 | 33 | |
| GSE46452 | GPR3 | 2827 | 5 | 1 | 53 | |
| GSE47630 | GPR3 | 2827 | 8 | 3 | 29 | |
| GSE54993 | GPR3 | 2827 | 2 | 1 | 67 | |
| GSE54994 | GPR3 | 2827 | 10 | 4 | 39 | |
| GSE60625 | GPR3 | 2827 | 0 | 0 | 11 | |
| GSE74703 | GPR3 | 2827 | 3 | 4 | 29 | |
| GSE74704 | GPR3 | 2827 | 0 | 0 | 20 | |
| TCGA | GPR3 | 2827 | 11 | 23 | 62 |
Total number of gains: 43; Total number of losses: 53; Total Number of normals: 392.
Somatic mutations of GPR3:
Generating mutation plots.
Highly correlated genes for GPR3:
Showing top 20/324 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR3 | HABP4 | 0.80046 | 3 | 0 | 3 |
| GPR3 | MRPL33 | 0.798444 | 3 | 0 | 3 |
| GPR3 | NR4A2 | 0.762243 | 3 | 0 | 3 |
| GPR3 | SOX5 | 0.755972 | 3 | 0 | 3 |
| GPR3 | LIX1L | 0.747026 | 3 | 0 | 3 |
| GPR3 | IRS2 | 0.74391 | 3 | 0 | 3 |
| GPR3 | PYGO1 | 0.730736 | 3 | 0 | 3 |
| GPR3 | SNX25 | 0.722792 | 3 | 0 | 3 |
| GPR3 | PREX2 | 0.72115 | 5 | 0 | 5 |
| GPR3 | LRP3 | 0.719656 | 3 | 0 | 3 |
| GPR3 | NR4A1 | 0.708676 | 4 | 0 | 3 |
| GPR3 | KIF13A | 0.708554 | 3 | 0 | 3 |
| GPR3 | ABHD1 | 0.706713 | 3 | 0 | 3 |
| GPR3 | HES6 | 0.705611 | 3 | 0 | 3 |
| GPR3 | STK17A | 0.701355 | 3 | 0 | 3 |
| GPR3 | YBEY | 0.694289 | 3 | 0 | 3 |
| GPR3 | TNFSF9 | 0.694144 | 3 | 0 | 3 |
| GPR3 | SORBS3 | 0.693977 | 3 | 0 | 3 |
| GPR3 | ARHGAP4 | 0.690286 | 3 | 0 | 3 |
| GPR3 | IDS | 0.689224 | 4 | 0 | 3 |
For details and further investigation, click here
