| Full name: Sp6 transcription factor | Alias Symbol: KLF14|Epfn | ||
| Type: protein-coding gene | Cytoband: 17q21.32 | ||
| Entrez ID: 80320 | HGNC ID: HGNC:14530 | Ensembl Gene: ENSG00000189120 | OMIM ID: 608613 |
| Drug and gene relationship at DGIdb | |||
Expression of SP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SP6 | 80320 | 228975_at | 0.1227 | 0.7372 | |
| GSE26886 | SP6 | 80320 | 228975_at | -0.4614 | 0.0076 | |
| GSE45670 | SP6 | 80320 | 228975_at | -0.1683 | 0.3047 | |
| GSE53622 | SP6 | 80320 | 11104 | -0.1920 | 0.0020 | |
| GSE53624 | SP6 | 80320 | 11104 | -0.5120 | 0.0000 | |
| GSE63941 | SP6 | 80320 | 228975_at | 0.5487 | 0.0257 | |
| GSE77861 | SP6 | 80320 | 228975_at | -0.3148 | 0.1125 | |
| GSE97050 | SP6 | 80320 | A_33_P3282075 | -0.1510 | 0.5544 | |
| SRP007169 | SP6 | 80320 | RNAseq | -2.7281 | 0.0000 | |
| SRP008496 | SP6 | 80320 | RNAseq | -1.7985 | 0.0016 | |
| SRP064894 | SP6 | 80320 | RNAseq | -0.8479 | 0.0101 | |
| SRP133303 | SP6 | 80320 | RNAseq | -0.3045 | 0.4863 | |
| SRP159526 | SP6 | 80320 | RNAseq | -0.6997 | 0.2863 | |
| SRP193095 | SP6 | 80320 | RNAseq | -0.3634 | 0.1982 | |
| SRP219564 | SP6 | 80320 | RNAseq | 1.4211 | 0.2215 | |
| TCGA | SP6 | 80320 | RNAseq | 0.6342 | 0.0010 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SP6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SP6 | 80320 | 5 | 2 | 23 | |
| GSE20123 | SP6 | 80320 | 5 | 2 | 23 | |
| GSE43470 | SP6 | 80320 | 1 | 2 | 40 | |
| GSE46452 | SP6 | 80320 | 32 | 0 | 27 | |
| GSE47630 | SP6 | 80320 | 9 | 0 | 31 | |
| GSE54993 | SP6 | 80320 | 2 | 4 | 64 | |
| GSE54994 | SP6 | 80320 | 11 | 5 | 37 | |
| GSE60625 | SP6 | 80320 | 4 | 0 | 7 | |
| GSE74703 | SP6 | 80320 | 1 | 1 | 34 | |
| GSE74704 | SP6 | 80320 | 4 | 1 | 15 | |
| TCGA | SP6 | 80320 | 28 | 6 | 62 |
Total number of gains: 102; Total number of losses: 23; Total Number of normals: 363.
Somatic mutations of SP6:
Generating mutation plots.
Highly correlated genes for SP6:
Showing top 20/368 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SP6 | NUDT13 | 0.818249 | 3 | 0 | 3 |
| SP6 | TERT | 0.795781 | 4 | 0 | 4 |
| SP6 | ESPNL | 0.770395 | 4 | 0 | 4 |
| SP6 | ADAMTS13 | 0.755395 | 3 | 0 | 3 |
| SP6 | C11orf86 | 0.749546 | 3 | 0 | 3 |
| SP6 | PRSS38 | 0.746758 | 3 | 0 | 3 |
| SP6 | DYTN | 0.74046 | 3 | 0 | 3 |
| SP6 | ENTPD8 | 0.727875 | 3 | 0 | 3 |
| SP6 | OR13G1 | 0.725542 | 3 | 0 | 3 |
| SP6 | LCN8 | 0.722962 | 3 | 0 | 3 |
| SP6 | GALR3 | 0.722958 | 4 | 0 | 4 |
| SP6 | SLC25A47 | 0.722081 | 3 | 0 | 3 |
| SP6 | MMP17 | 0.718675 | 3 | 0 | 3 |
| SP6 | GDF7 | 0.716258 | 3 | 0 | 3 |
| SP6 | B3GNT8 | 0.710164 | 4 | 0 | 4 |
| SP6 | TBKBP1 | 0.709783 | 4 | 0 | 4 |
| SP6 | BTK | 0.708544 | 4 | 0 | 4 |
| SP6 | OR10G8 | 0.704821 | 3 | 0 | 3 |
| SP6 | ONECUT1 | 0.704457 | 3 | 0 | 3 |
| SP6 | CLDN24 | 0.70312 | 3 | 0 | 3 |
For details and further investigation, click here
