| Full name: TBK1 binding protein 1 | Alias Symbol: ProSAPiP2|KIAA0775 | ||
| Type: protein-coding gene | Cytoband: 17q21.32 | ||
| Entrez ID: 9755 | HGNC ID: HGNC:30140 | Ensembl Gene: ENSG00000198933 | OMIM ID: 608476 |
| Drug and gene relationship at DGIdb | |||
TBKBP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04622 | RIG-I-like receptor signaling pathway |
Expression of TBKBP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBKBP1 | 9755 | 205424_at | -0.1333 | 0.6027 | |
| GSE20347 | TBKBP1 | 9755 | 205424_at | -0.1681 | 0.0502 | |
| GSE23400 | TBKBP1 | 9755 | 205424_at | -0.2091 | 0.0000 | |
| GSE26886 | TBKBP1 | 9755 | 205424_at | 0.0314 | 0.8443 | |
| GSE29001 | TBKBP1 | 9755 | 205424_at | -0.3210 | 0.0475 | |
| GSE38129 | TBKBP1 | 9755 | 205424_at | -0.3112 | 0.0001 | |
| GSE45670 | TBKBP1 | 9755 | 205424_at | -0.1587 | 0.1610 | |
| GSE53622 | TBKBP1 | 9755 | 41807 | -0.2400 | 0.0009 | |
| GSE53624 | TBKBP1 | 9755 | 106953 | -0.9187 | 0.0000 | |
| GSE63941 | TBKBP1 | 9755 | 205424_at | 0.2492 | 0.1554 | |
| GSE77861 | TBKBP1 | 9755 | 205424_at | -0.3139 | 0.0512 | |
| GSE97050 | TBKBP1 | 9755 | A_23_P130169 | -0.1797 | 0.4245 | |
| SRP007169 | TBKBP1 | 9755 | RNAseq | -2.1095 | 0.0000 | |
| SRP008496 | TBKBP1 | 9755 | RNAseq | -2.2469 | 0.0000 | |
| SRP064894 | TBKBP1 | 9755 | RNAseq | -0.2413 | 0.3306 | |
| SRP133303 | TBKBP1 | 9755 | RNAseq | -0.9282 | 0.0000 | |
| SRP159526 | TBKBP1 | 9755 | RNAseq | -0.3743 | 0.1801 | |
| SRP193095 | TBKBP1 | 9755 | RNAseq | -0.6887 | 0.0033 | |
| SRP219564 | TBKBP1 | 9755 | RNAseq | -0.3570 | 0.3523 | |
| TCGA | TBKBP1 | 9755 | RNAseq | -0.2153 | 0.0077 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by TBKBP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBKBP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBKBP1 | 9755 | 5 | 2 | 23 | |
| GSE20123 | TBKBP1 | 9755 | 5 | 2 | 23 | |
| GSE43470 | TBKBP1 | 9755 | 1 | 2 | 40 | |
| GSE46452 | TBKBP1 | 9755 | 32 | 0 | 27 | |
| GSE47630 | TBKBP1 | 9755 | 9 | 0 | 31 | |
| GSE54993 | TBKBP1 | 9755 | 2 | 4 | 64 | |
| GSE54994 | TBKBP1 | 9755 | 11 | 5 | 37 | |
| GSE60625 | TBKBP1 | 9755 | 4 | 0 | 7 | |
| GSE74703 | TBKBP1 | 9755 | 1 | 1 | 34 | |
| GSE74704 | TBKBP1 | 9755 | 4 | 1 | 15 | |
| TCGA | TBKBP1 | 9755 | 28 | 6 | 62 |
Total number of gains: 102; Total number of losses: 23; Total Number of normals: 363.
Somatic mutations of TBKBP1:
Generating mutation plots.
Highly correlated genes for TBKBP1:
Showing top 20/738 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBKBP1 | PGC | 0.750939 | 4 | 0 | 4 |
| TBKBP1 | KRTAP4-8 | 0.739868 | 3 | 0 | 3 |
| TBKBP1 | FBF1 | 0.729851 | 4 | 0 | 3 |
| TBKBP1 | CDX2 | 0.723549 | 7 | 0 | 7 |
| TBKBP1 | OR2C3 | 0.716884 | 3 | 0 | 3 |
| TBKBP1 | TMUB1 | 0.714602 | 3 | 0 | 3 |
| TBKBP1 | PLEKHN1 | 0.713777 | 5 | 0 | 5 |
| TBKBP1 | PPP1R3F | 0.711384 | 3 | 0 | 3 |
| TBKBP1 | SP6 | 0.709783 | 4 | 0 | 4 |
| TBKBP1 | SLC6A18 | 0.709447 | 3 | 0 | 3 |
| TBKBP1 | FAM71A | 0.706947 | 4 | 0 | 4 |
| TBKBP1 | TMEM217 | 0.706095 | 5 | 0 | 5 |
| TBKBP1 | TMEM175 | 0.700351 | 3 | 0 | 3 |
| TBKBP1 | MMP17 | 0.698037 | 3 | 0 | 3 |
| TBKBP1 | RDH13 | 0.69474 | 4 | 0 | 3 |
| TBKBP1 | GPR26 | 0.687739 | 3 | 0 | 3 |
| TBKBP1 | SPRN | 0.686331 | 3 | 0 | 3 |
| TBKBP1 | CPA5 | 0.683939 | 3 | 0 | 3 |
| TBKBP1 | TDRD1 | 0.683896 | 4 | 0 | 4 |
| TBKBP1 | B3GNT8 | 0.683256 | 4 | 0 | 3 |
For details and further investigation, click here
