| Full name: signal peptidase complex subunit 3 | Alias Symbol: FLJ22649|SPC22/23|SPC3|YLR066W|PRO3567 | ||
| Type: protein-coding gene | Cytoband: 4q34.2 | ||
| Entrez ID: 60559 | HGNC ID: HGNC:26212 | Ensembl Gene: ENSG00000129128 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SPCS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPCS3 | 60559 | 221844_x_at | 0.2041 | 0.7558 | |
| GSE20347 | SPCS3 | 60559 | 221844_x_at | -0.3693 | 0.0073 | |
| GSE23400 | SPCS3 | 60559 | 221844_x_at | 0.0494 | 0.5054 | |
| GSE26886 | SPCS3 | 60559 | 221844_x_at | -0.2287 | 0.0662 | |
| GSE29001 | SPCS3 | 60559 | 221844_x_at | -0.2955 | 0.0793 | |
| GSE38129 | SPCS3 | 60559 | 221844_x_at | -0.1987 | 0.0901 | |
| GSE45670 | SPCS3 | 60559 | 221844_x_at | -0.1162 | 0.5059 | |
| GSE53622 | SPCS3 | 60559 | 9345 | -0.0972 | 0.1969 | |
| GSE53624 | SPCS3 | 60559 | 9345 | -0.0365 | 0.6585 | |
| GSE63941 | SPCS3 | 60559 | 221844_x_at | -1.3734 | 0.0089 | |
| GSE77861 | SPCS3 | 60559 | 221844_x_at | 0.1385 | 0.3446 | |
| GSE97050 | SPCS3 | 60559 | A_23_P132936 | 0.8633 | 0.1255 | |
| SRP007169 | SPCS3 | 60559 | RNAseq | -0.5058 | 0.1425 | |
| SRP008496 | SPCS3 | 60559 | RNAseq | -0.3334 | 0.0665 | |
| SRP064894 | SPCS3 | 60559 | RNAseq | 0.0701 | 0.6458 | |
| SRP133303 | SPCS3 | 60559 | RNAseq | 0.4867 | 0.0214 | |
| SRP159526 | SPCS3 | 60559 | RNAseq | -0.0684 | 0.7590 | |
| SRP193095 | SPCS3 | 60559 | RNAseq | -0.3810 | 0.0055 | |
| SRP219564 | SPCS3 | 60559 | RNAseq | -0.0602 | 0.8461 | |
| TCGA | SPCS3 | 60559 | RNAseq | -0.1888 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SPCS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPCS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPCS3 | 60559 | 1 | 10 | 19 | |
| GSE20123 | SPCS3 | 60559 | 1 | 10 | 19 | |
| GSE43470 | SPCS3 | 60559 | 0 | 14 | 29 | |
| GSE46452 | SPCS3 | 60559 | 1 | 36 | 22 | |
| GSE47630 | SPCS3 | 60559 | 0 | 22 | 18 | |
| GSE54993 | SPCS3 | 60559 | 10 | 0 | 60 | |
| GSE54994 | SPCS3 | 60559 | 2 | 12 | 39 | |
| GSE60625 | SPCS3 | 60559 | 0 | 0 | 11 | |
| GSE74703 | SPCS3 | 60559 | 0 | 12 | 24 | |
| GSE74704 | SPCS3 | 60559 | 0 | 5 | 15 | |
| TCGA | SPCS3 | 60559 | 10 | 36 | 50 |
Total number of gains: 25; Total number of losses: 157; Total Number of normals: 306.
Somatic mutations of SPCS3:
Generating mutation plots.
Highly correlated genes for SPCS3:
Showing top 20/292 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPCS3 | EIF5B | 0.736445 | 3 | 0 | 3 |
| SPCS3 | PTPN22 | 0.718279 | 4 | 0 | 4 |
| SPCS3 | CXCL13 | 0.718053 | 3 | 0 | 3 |
| SPCS3 | SH3KBP1 | 0.713859 | 3 | 0 | 3 |
| SPCS3 | ZNF562 | 0.708671 | 3 | 0 | 3 |
| SPCS3 | MINK1 | 0.708238 | 3 | 0 | 3 |
| SPCS3 | CABLES1 | 0.706434 | 3 | 0 | 3 |
| SPCS3 | RNF24 | 0.703481 | 3 | 0 | 3 |
| SPCS3 | CMTM6 | 0.698456 | 4 | 0 | 4 |
| SPCS3 | ATP6V0D1 | 0.692423 | 3 | 0 | 3 |
| SPCS3 | CAPZA2 | 0.677155 | 3 | 0 | 3 |
| SPCS3 | PHF6 | 0.676417 | 3 | 0 | 3 |
| SPCS3 | ZNF521 | 0.673818 | 3 | 0 | 3 |
| SPCS3 | A1BG | 0.673211 | 3 | 0 | 3 |
| SPCS3 | C1orf162 | 0.670412 | 4 | 0 | 3 |
| SPCS3 | KDM5B | 0.667583 | 3 | 0 | 3 |
| SPCS3 | GOSR2 | 0.664988 | 3 | 0 | 3 |
| SPCS3 | FKBP10 | 0.66412 | 3 | 0 | 3 |
| SPCS3 | CLEC11A | 0.659631 | 3 | 0 | 3 |
| SPCS3 | C2orf69 | 0.659296 | 3 | 0 | 3 |
For details and further investigation, click here
