| Full name: protein tyrosine phosphatase non-receptor type 22 | Alias Symbol: Lyp|Lyp1|Lyp2 | ||
| Type: protein-coding gene | Cytoband: 1p13.2 | ||
| Entrez ID: 26191 | HGNC ID: HGNC:9652 | Ensembl Gene: ENSG00000134242 | OMIM ID: 600716 |
| Drug and gene relationship at DGIdb | |||
Expression of PTPN22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTPN22 | 26191 | 206060_s_at | 0.4504 | 0.6509 | |
| GSE20347 | PTPN22 | 26191 | 206060_s_at | -0.3228 | 0.0732 | |
| GSE23400 | PTPN22 | 26191 | 206060_s_at | -0.1736 | 0.0001 | |
| GSE26886 | PTPN22 | 26191 | 206060_s_at | -0.8722 | 0.0046 | |
| GSE29001 | PTPN22 | 26191 | 206060_s_at | -0.5645 | 0.0275 | |
| GSE38129 | PTPN22 | 26191 | 206060_s_at | -0.2703 | 0.1149 | |
| GSE45670 | PTPN22 | 26191 | 206060_s_at | -0.0925 | 0.7927 | |
| GSE53622 | PTPN22 | 26191 | 62042 | -0.7726 | 0.0000 | |
| GSE53624 | PTPN22 | 26191 | 62042 | -1.1722 | 0.0000 | |
| GSE63941 | PTPN22 | 26191 | 206060_s_at | 0.1113 | 0.7214 | |
| GSE77861 | PTPN22 | 26191 | 206060_s_at | -0.2728 | 0.0452 | |
| GSE97050 | PTPN22 | 26191 | A_23_P201181 | 0.9266 | 0.1747 | |
| SRP007169 | PTPN22 | 26191 | RNAseq | -0.8610 | 0.1488 | |
| SRP064894 | PTPN22 | 26191 | RNAseq | -0.3484 | 0.3593 | |
| SRP133303 | PTPN22 | 26191 | RNAseq | -0.2385 | 0.3083 | |
| SRP159526 | PTPN22 | 26191 | RNAseq | -1.1837 | 0.1472 | |
| SRP193095 | PTPN22 | 26191 | RNAseq | -0.9344 | 0.0001 | |
| SRP219564 | PTPN22 | 26191 | RNAseq | 0.1706 | 0.8142 | |
| TCGA | PTPN22 | 26191 | RNAseq | 0.0185 | 0.9252 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PTPN22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTPN22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTPN22 | 26191 | 0 | 9 | 21 | |
| GSE20123 | PTPN22 | 26191 | 0 | 9 | 21 | |
| GSE43470 | PTPN22 | 26191 | 0 | 8 | 35 | |
| GSE46452 | PTPN22 | 26191 | 2 | 1 | 56 | |
| GSE47630 | PTPN22 | 26191 | 9 | 5 | 26 | |
| GSE54993 | PTPN22 | 26191 | 0 | 1 | 69 | |
| GSE54994 | PTPN22 | 26191 | 7 | 3 | 43 | |
| GSE60625 | PTPN22 | 26191 | 0 | 0 | 11 | |
| GSE74703 | PTPN22 | 26191 | 0 | 7 | 29 | |
| GSE74704 | PTPN22 | 26191 | 0 | 5 | 15 | |
| TCGA | PTPN22 | 26191 | 11 | 30 | 55 |
Total number of gains: 29; Total number of losses: 78; Total Number of normals: 381.
Somatic mutations of PTPN22:
Generating mutation plots.
Highly correlated genes for PTPN22:
Showing top 20/472 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTPN22 | CD38 | 0.766439 | 4 | 0 | 4 |
| PTPN22 | CR1L | 0.758582 | 3 | 0 | 3 |
| PTPN22 | ATRNL1 | 0.755181 | 3 | 0 | 3 |
| PTPN22 | GZMA | 0.747315 | 5 | 0 | 5 |
| PTPN22 | GNGT2 | 0.746991 | 3 | 0 | 3 |
| PTPN22 | ZC3H12D | 0.739204 | 4 | 0 | 4 |
| PTPN22 | LAX1 | 0.7351 | 4 | 0 | 3 |
| PTPN22 | TRG-AS1 | 0.729261 | 3 | 0 | 3 |
| PTPN22 | SCML4 | 0.721587 | 3 | 0 | 3 |
| PTPN22 | SPCS3 | 0.718279 | 4 | 0 | 4 |
| PTPN22 | STAP1 | 0.717349 | 4 | 0 | 4 |
| PTPN22 | UHRF2 | 0.716729 | 4 | 0 | 3 |
| PTPN22 | PCED1B-AS1 | 0.711636 | 3 | 0 | 3 |
| PTPN22 | SLCO2A1 | 0.71008 | 3 | 0 | 3 |
| PTPN22 | SAMD3 | 0.706162 | 4 | 0 | 4 |
| PTPN22 | SOX9-AS1 | 0.701047 | 3 | 0 | 3 |
| PTPN22 | FCRLA | 0.690322 | 3 | 0 | 3 |
| PTPN22 | CD2 | 0.68186 | 7 | 0 | 6 |
| PTPN22 | LACTBL1 | 0.678128 | 3 | 0 | 3 |
| PTPN22 | SPOCK2 | 0.677526 | 4 | 0 | 3 |
For details and further investigation, click here
