| Full name: misshapen like kinase 1 | Alias Symbol: B55|MINK|ZC3|MAP4K6|YSK2 | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 50488 | HGNC ID: HGNC:17565 | Ensembl Gene: ENSG00000141503 | OMIM ID: 609426 |
| Drug and gene relationship at DGIdb | |||
Expression of MINK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MINK1 | 50488 | 214246_x_at | 0.0113 | 0.9921 | |
| GSE20347 | MINK1 | 50488 | 214246_x_at | -0.5355 | 0.0019 | |
| GSE23400 | MINK1 | 50488 | 214246_x_at | -0.1893 | 0.0400 | |
| GSE26886 | MINK1 | 50488 | 214246_x_at | -0.4088 | 0.1308 | |
| GSE29001 | MINK1 | 50488 | 214246_x_at | -0.4330 | 0.4871 | |
| GSE38129 | MINK1 | 50488 | 214246_x_at | -0.2069 | 0.2531 | |
| GSE45670 | MINK1 | 50488 | 214246_x_at | 0.1115 | 0.5248 | |
| GSE53622 | MINK1 | 50488 | 46437 | -0.3544 | 0.0001 | |
| GSE53624 | MINK1 | 50488 | 46437 | -0.5893 | 0.0000 | |
| GSE63941 | MINK1 | 50488 | 214246_x_at | 0.2444 | 0.4918 | |
| GSE77861 | MINK1 | 50488 | 214246_x_at | -0.0822 | 0.8530 | |
| GSE97050 | MINK1 | 50488 | A_23_P164313 | 0.1166 | 0.6996 | |
| SRP007169 | MINK1 | 50488 | RNAseq | -1.0071 | 0.0081 | |
| SRP008496 | MINK1 | 50488 | RNAseq | -1.2224 | 0.0000 | |
| SRP064894 | MINK1 | 50488 | RNAseq | -0.6049 | 0.0075 | |
| SRP133303 | MINK1 | 50488 | RNAseq | -0.6730 | 0.0023 | |
| SRP159526 | MINK1 | 50488 | RNAseq | -0.7859 | 0.0000 | |
| SRP193095 | MINK1 | 50488 | RNAseq | -0.2290 | 0.0849 | |
| SRP219564 | MINK1 | 50488 | RNAseq | -0.5572 | 0.3119 | |
| TCGA | MINK1 | 50488 | RNAseq | 0.0272 | 0.6091 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by MINK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MINK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MINK1 | 50488 | 5 | 2 | 23 | |
| GSE20123 | MINK1 | 50488 | 5 | 3 | 22 | |
| GSE43470 | MINK1 | 50488 | 1 | 6 | 36 | |
| GSE46452 | MINK1 | 50488 | 34 | 1 | 24 | |
| GSE47630 | MINK1 | 50488 | 7 | 1 | 32 | |
| GSE54993 | MINK1 | 50488 | 4 | 3 | 63 | |
| GSE54994 | MINK1 | 50488 | 5 | 9 | 39 | |
| GSE60625 | MINK1 | 50488 | 4 | 0 | 7 | |
| GSE74703 | MINK1 | 50488 | 1 | 3 | 32 | |
| GSE74704 | MINK1 | 50488 | 3 | 1 | 16 | |
| TCGA | MINK1 | 50488 | 19 | 21 | 56 |
Total number of gains: 88; Total number of losses: 50; Total Number of normals: 350.
Somatic mutations of MINK1:
Generating mutation plots.
Highly correlated genes for MINK1:
Showing top 20/659 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MINK1 | MXD3 | 0.796078 | 3 | 0 | 3 |
| MINK1 | STXBP5 | 0.76448 | 3 | 0 | 3 |
| MINK1 | ZBTB33 | 0.760615 | 3 | 0 | 3 |
| MINK1 | EBPL | 0.734153 | 3 | 0 | 3 |
| MINK1 | SMN2 | 0.729813 | 3 | 0 | 3 |
| MINK1 | SPCS3 | 0.708238 | 3 | 0 | 3 |
| MINK1 | VAMP2 | 0.705249 | 4 | 0 | 3 |
| MINK1 | LAMP1 | 0.702745 | 4 | 0 | 4 |
| MINK1 | SYN3 | 0.700747 | 3 | 0 | 3 |
| MINK1 | MOB3C | 0.696648 | 3 | 0 | 3 |
| MINK1 | DMBT1 | 0.696257 | 4 | 0 | 3 |
| MINK1 | CTDSPL | 0.696204 | 3 | 0 | 3 |
| MINK1 | APBB1IP | 0.693713 | 3 | 0 | 3 |
| MINK1 | WNK1 | 0.693315 | 4 | 0 | 4 |
| MINK1 | ALKBH3 | 0.690131 | 4 | 0 | 4 |
| MINK1 | PAQR7 | 0.68971 | 4 | 0 | 3 |
| MINK1 | ATAT1 | 0.682829 | 4 | 0 | 3 |
| MINK1 | MARVELD2 | 0.681399 | 4 | 0 | 3 |
| MINK1 | ADAM15 | 0.677734 | 7 | 0 | 6 |
| MINK1 | PHRF1 | 0.676884 | 4 | 0 | 3 |
For details and further investigation, click here
