KNTC1

 

Full name: kinetochore associated 1 Alias Symbol: KIAA0166|ROD
Type: protein-coding gene Cytoband: 12q24.31
Entrez ID: 9735 HGNC ID: HGNC:17255 Ensembl Gene: ENSG00000184445 OMIM ID: 607363
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of KNTC1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KNTC1 9735 206316_s_at 0.9749 0.0171
GSE20347 KNTC1 9735 206316_s_at 1.2444 0.0000
GSE23400 KNTC1 9735 206316_s_at 0.6290 0.0000
GSE26886 KNTC1 9735 206316_s_at 0.6968 0.0092
GSE29001 KNTC1 9735 206316_s_at 1.3301 0.0000
GSE38129 KNTC1 9735 206316_s_at 1.3407 0.0000
GSE45670 KNTC1 9735 206316_s_at 0.9556 0.0000
GSE53622 KNTC1 9735 57214 1.4700 0.0000
GSE53624 KNTC1 9735 57214 1.5065 0.0000
GSE63941 KNTC1 9735 206316_s_at 1.6840 0.0044
GSE77861 KNTC1 9735 206316_s_at 1.1653 0.0020
GSE97050 KNTC1 9735 A_23_P136817 0.8597 0.1450
SRP007169 KNTC1 9735 RNAseq 1.8650 0.0001
SRP008496 KNTC1 9735 RNAseq 1.6958 0.0000
SRP064894 KNTC1 9735 RNAseq 1.2331 0.0001
SRP133303 KNTC1 9735 RNAseq 1.1866 0.0000
SRP159526 KNTC1 9735 RNAseq 1.7024 0.0001
SRP193095 KNTC1 9735 RNAseq 0.8672 0.0000
SRP219564 KNTC1 9735 RNAseq 1.0456 0.0201
TCGA KNTC1 9735 RNAseq 0.5992 0.0000

Upregulated datasets: 13; Downregulated datasets: 0.  

 

Survival by KNTC1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of KNTC1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KNTC1 9735 5 4 21
GSE20123 KNTC1 9735 5 4 21
GSE43470 KNTC1 9735 2 1 40
GSE46452 KNTC1 9735 9 1 49
GSE47630 KNTC1 9735 9 3 28
GSE54993 KNTC1 9735 0 5 65
GSE54994 KNTC1 9735 5 7 41
GSE60625 KNTC1 9735 0 0 11
GSE74703 KNTC1 9735 2 0 34
GSE74704 KNTC1 9735 4 2 14
TCGA KNTC1 9735 21 10 65

Total number of gains: 62; Total number of losses: 37; Total Number of normals: 389.  

 

Somatic mutations of KNTC1:

 

Generating mutation plots.

 

Highly correlated genes for KNTC1:

 

Showing top 20/1996 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KNTC1TOP2A0.82861612012
KNTC1TIMELESS0.82480612012
KNTC1GINS10.80966212012
KNTC1CEP550.80550311011
KNTC1NCAPG20.80042211011
KNTC1CENPF0.79983413012
KNTC1GMNN0.79604812012
KNTC1KIF230.79572811011
KNTC1FANCI0.7947512012
KNTC1UBE2C0.78874512011
KNTC1MCM60.78633313013
KNTC1ASPM0.7834413013
KNTC1CDK10.78224311011
KNTC1TRIP130.78087911011
KNTC1CENPI0.7800312011
KNTC1MMS22L0.778416303
KNTC1CKS1B0.77786412012
KNTC1DTL0.77583913012
KNTC1FANCB0.77559606
KNTC1ZIC50.774816303

For details and further investigation, click here