SLC12A9

 

Full name: solute carrier family 12 member 9 Alias Symbol: CIP1
Type: protein-coding gene Cytoband: 7q22.1
Entrez ID: 56996 HGNC ID: HGNC:17435 Ensembl Gene: ENSG00000146828 OMIM ID: 616861
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SLC12A9:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SLC12A9 56996 220371_s_at 0.4815 0.1858
GSE20347 SLC12A9 56996 220371_s_at 0.4057 0.0000
GSE23400 SLC12A9 56996 220371_s_at 0.3304 0.0000
GSE26886 SLC12A9 56996 220371_s_at 1.0834 0.0000
GSE29001 SLC12A9 56996 220371_s_at 0.1979 0.2814
GSE38129 SLC12A9 56996 220371_s_at 0.4079 0.0000
GSE45670 SLC12A9 56996 220371_s_at 0.3596 0.0067
GSE53622 SLC12A9 56996 121432 0.6064 0.0000
GSE53624 SLC12A9 56996 121432 0.8507 0.0000
GSE63941 SLC12A9 56996 220371_s_at -0.2960 0.2957
GSE77861 SLC12A9 56996 220371_s_at 0.2439 0.1078
GSE97050 SLC12A9 56996 A_33_P3229181 0.5158 0.1655
SRP007169 SLC12A9 56996 RNAseq 0.4533 0.2831
SRP008496 SLC12A9 56996 RNAseq 0.2552 0.4614
SRP064894 SLC12A9 56996 RNAseq 0.8573 0.0000
SRP133303 SLC12A9 56996 RNAseq 0.4651 0.0050
SRP159526 SLC12A9 56996 RNAseq 0.4090 0.0426
SRP193095 SLC12A9 56996 RNAseq 0.7651 0.0000
SRP219564 SLC12A9 56996 RNAseq 0.7746 0.0124
TCGA SLC12A9 56996 RNAseq 0.1922 0.0007

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by SLC12A9 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SLC12A9:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SLC12A9 56996 13 0 17
GSE20123 SLC12A9 56996 13 0 17
GSE43470 SLC12A9 56996 7 2 34
GSE46452 SLC12A9 56996 11 1 47
GSE47630 SLC12A9 56996 7 3 30
GSE54993 SLC12A9 56996 1 9 60
GSE54994 SLC12A9 56996 15 3 35
GSE60625 SLC12A9 56996 0 0 11
GSE74703 SLC12A9 56996 7 1 28
GSE74704 SLC12A9 56996 9 0 11
TCGA SLC12A9 56996 52 7 37

Total number of gains: 135; Total number of losses: 26; Total Number of normals: 327.  

 

Somatic mutations of SLC12A9:

 

Generating mutation plots.

 

Highly correlated genes for SLC12A9:

 

Showing top 20/1558 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SLC12A9SEMA3C0.787513303
SLC12A9RRP360.782304303
SLC12A9SRRT0.7584411011
SLC12A9PPP1R350.749523707
SLC12A9ARHGDIA0.742268404
SLC12A9PTCD10.734739404
SLC12A9PCIF10.728196303
SLC12A9RAVER10.726292504
SLC12A9ZAP700.72297403
SLC12A9TAF60.71069311011
SLC12A9NACC10.706479505
SLC12A9PYCR20.703129303
SLC12A9SSBP40.70155504
SLC12A9B3GALT60.700323605
SLC12A9CCDC240.699798505
SLC12A9TRIM470.699549404
SLC12A9POP70.6991541109
SLC12A9GPATCH20.69664303
SLC12A9TMEM161A0.69657710010
SLC12A9MCM70.6945171008

For details and further investigation, click here