| Full name: SPG11 vesicle trafficking associated, spatacsin | Alias Symbol: FLJ21439 | ||
| Type: protein-coding gene | Cytoband: 15q21.1 | ||
| Entrez ID: 80208 | HGNC ID: HGNC:11226 | Ensembl Gene: ENSG00000104133 | OMIM ID: 610844 |
| Drug and gene relationship at DGIdb | |||
Expression of SPG11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPG11 | 80208 | 203513_at | -0.5693 | 0.0399 | |
| GSE20347 | SPG11 | 80208 | 203513_at | -0.3840 | 0.0002 | |
| GSE23400 | SPG11 | 80208 | 203513_at | -0.1437 | 0.0711 | |
| GSE26886 | SPG11 | 80208 | 203513_at | 0.1732 | 0.5165 | |
| GSE29001 | SPG11 | 80208 | 203513_at | -0.3513 | 0.2193 | |
| GSE38129 | SPG11 | 80208 | 203513_at | -0.3775 | 0.0001 | |
| GSE45670 | SPG11 | 80208 | 203513_at | -0.1166 | 0.4720 | |
| GSE53622 | SPG11 | 80208 | 111085 | -0.3997 | 0.0000 | |
| GSE53624 | SPG11 | 80208 | 111085 | -0.6490 | 0.0000 | |
| GSE63941 | SPG11 | 80208 | 203513_at | -0.4611 | 0.2992 | |
| GSE77861 | SPG11 | 80208 | 203513_at | -0.1354 | 0.5204 | |
| GSE97050 | SPG11 | 80208 | A_23_P65699 | -0.4480 | 0.1623 | |
| SRP007169 | SPG11 | 80208 | RNAseq | -0.3682 | 0.2921 | |
| SRP008496 | SPG11 | 80208 | RNAseq | -0.3966 | 0.0591 | |
| SRP064894 | SPG11 | 80208 | RNAseq | -0.2808 | 0.1865 | |
| SRP133303 | SPG11 | 80208 | RNAseq | -0.1790 | 0.1385 | |
| SRP159526 | SPG11 | 80208 | RNAseq | -0.4139 | 0.3572 | |
| SRP193095 | SPG11 | 80208 | RNAseq | -0.2559 | 0.0034 | |
| SRP219564 | SPG11 | 80208 | RNAseq | -0.3157 | 0.2164 | |
| TCGA | SPG11 | 80208 | RNAseq | -0.1375 | 0.0015 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPG11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPG11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPG11 | 80208 | 3 | 4 | 23 | |
| GSE20123 | SPG11 | 80208 | 3 | 5 | 22 | |
| GSE43470 | SPG11 | 80208 | 4 | 4 | 35 | |
| GSE46452 | SPG11 | 80208 | 3 | 7 | 49 | |
| GSE47630 | SPG11 | 80208 | 8 | 10 | 22 | |
| GSE54993 | SPG11 | 80208 | 4 | 6 | 60 | |
| GSE54994 | SPG11 | 80208 | 5 | 7 | 41 | |
| GSE60625 | SPG11 | 80208 | 4 | 0 | 7 | |
| GSE74703 | SPG11 | 80208 | 4 | 3 | 29 | |
| GSE74704 | SPG11 | 80208 | 1 | 2 | 17 | |
| TCGA | SPG11 | 80208 | 12 | 16 | 68 |
Total number of gains: 51; Total number of losses: 64; Total Number of normals: 373.
Somatic mutations of SPG11:
Generating mutation plots.
Highly correlated genes for SPG11:
Showing top 20/862 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPG11 | ZBTB33 | 0.739742 | 3 | 0 | 3 |
| SPG11 | YAP1 | 0.726676 | 3 | 0 | 3 |
| SPG11 | SLC10A5 | 0.707475 | 3 | 0 | 3 |
| SPG11 | CD59 | 0.707258 | 3 | 0 | 3 |
| SPG11 | CCNDBP1 | 0.704957 | 6 | 0 | 6 |
| SPG11 | CA13 | 0.693972 | 3 | 0 | 3 |
| SPG11 | ZNF140 | 0.693513 | 4 | 0 | 3 |
| SPG11 | DNAJC3 | 0.689888 | 3 | 0 | 3 |
| SPG11 | SCRN3 | 0.688717 | 4 | 0 | 3 |
| SPG11 | BRK1 | 0.683961 | 4 | 0 | 4 |
| SPG11 | FGD4 | 0.682884 | 4 | 0 | 4 |
| SPG11 | SERF2 | 0.681331 | 3 | 0 | 3 |
| SPG11 | IFT74 | 0.680071 | 4 | 0 | 3 |
| SPG11 | BBIP1 | 0.679026 | 6 | 0 | 6 |
| SPG11 | ALKBH7 | 0.674676 | 4 | 0 | 4 |
| SPG11 | DLG2 | 0.671756 | 7 | 0 | 6 |
| SPG11 | TRERF1 | 0.669001 | 5 | 0 | 4 |
| SPG11 | ICK | 0.668094 | 4 | 0 | 3 |
| SPG11 | DCAF10 | 0.666891 | 5 | 0 | 4 |
| SPG11 | CCDC160 | 0.666864 | 3 | 0 | 3 |
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