| Full name: discs large MAGUK scaffold protein 2 | Alias Symbol: PSD-93|PSD93|chapsyn-110|PPP1R58 | ||
| Type: protein-coding gene | Cytoband: 11q14.1 | ||
| Entrez ID: 1740 | HGNC ID: HGNC:2901 | Ensembl Gene: ENSG00000150672 | OMIM ID: 603583 |
| Drug and gene relationship at DGIdb | |||
DLG2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04390 | Hippo signaling pathway |
Expression of DLG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DLG2 | 1740 | 228973_at | -1.3684 | 0.0054 | |
| GSE20347 | DLG2 | 1740 | 206253_at | -0.7938 | 0.0000 | |
| GSE23400 | DLG2 | 1740 | 206253_at | -0.1874 | 0.0000 | |
| GSE26886 | DLG2 | 1740 | 228973_at | -1.1519 | 0.0000 | |
| GSE29001 | DLG2 | 1740 | 206253_at | -1.0185 | 0.0002 | |
| GSE38129 | DLG2 | 1740 | 206253_at | -0.7425 | 0.0000 | |
| GSE45670 | DLG2 | 1740 | 228973_at | -1.2201 | 0.0001 | |
| GSE53622 | DLG2 | 1740 | 51119 | -1.2867 | 0.0000 | |
| GSE53624 | DLG2 | 1740 | 167158 | -3.6677 | 0.0000 | |
| GSE63941 | DLG2 | 1740 | 228973_at | -0.1628 | 0.3274 | |
| GSE77861 | DLG2 | 1740 | 228973_at | -0.4510 | 0.0048 | |
| GSE97050 | DLG2 | 1740 | A_23_P124514 | -0.2425 | 0.4174 | |
| SRP007169 | DLG2 | 1740 | RNAseq | -4.4405 | 0.0000 | |
| SRP064894 | DLG2 | 1740 | RNAseq | -1.9812 | 0.0000 | |
| SRP133303 | DLG2 | 1740 | RNAseq | -2.0619 | 0.0000 | |
| SRP159526 | DLG2 | 1740 | RNAseq | -4.0864 | 0.0000 | |
| SRP193095 | DLG2 | 1740 | RNAseq | -2.6770 | 0.0000 | |
| SRP219564 | DLG2 | 1740 | RNAseq | -1.1588 | 0.1871 | |
| TCGA | DLG2 | 1740 | RNAseq | -1.6557 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by DLG2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DLG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DLG2 | 1740 | 4 | 9 | 17 | |
| GSE20123 | DLG2 | 1740 | 4 | 9 | 17 | |
| GSE43470 | DLG2 | 1740 | 3 | 5 | 35 | |
| GSE46452 | DLG2 | 1740 | 6 | 24 | 29 | |
| GSE47630 | DLG2 | 1740 | 2 | 19 | 19 | |
| GSE54993 | DLG2 | 1740 | 8 | 2 | 60 | |
| GSE54994 | DLG2 | 1740 | 5 | 19 | 29 | |
| GSE60625 | DLG2 | 1740 | 0 | 4 | 7 | |
| GSE74703 | DLG2 | 1740 | 2 | 4 | 30 | |
| GSE74704 | DLG2 | 1740 | 3 | 6 | 11 | |
| TCGA | DLG2 | 1740 | 18 | 37 | 41 |
Total number of gains: 55; Total number of losses: 138; Total Number of normals: 295.
Somatic mutations of DLG2:
Generating mutation plots.
Highly correlated genes for DLG2:
Showing top 20/2101 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DLG2 | SNORA68 | 0.826872 | 4 | 0 | 4 |
| DLG2 | SLC16A6 | 0.826315 | 10 | 0 | 10 |
| DLG2 | PLEKHA7 | 0.815389 | 6 | 0 | 6 |
| DLG2 | A2ML1 | 0.809269 | 5 | 0 | 5 |
| DLG2 | TFAP2B | 0.8081 | 9 | 0 | 9 |
| DLG2 | C5orf66-AS1 | 0.807784 | 5 | 0 | 5 |
| DLG2 | FAM214A | 0.806064 | 5 | 0 | 5 |
| DLG2 | SCNN1B | 0.805834 | 9 | 0 | 9 |
| DLG2 | SLC46A2 | 0.805221 | 6 | 0 | 6 |
| DLG2 | TMPRSS11B | 0.801066 | 5 | 0 | 5 |
| DLG2 | GOLGA4 | 0.799219 | 8 | 0 | 8 |
| DLG2 | GDPD3 | 0.798196 | 9 | 0 | 9 |
| DLG2 | GBP6 | 0.793982 | 4 | 0 | 4 |
| DLG2 | EIF4E3 | 0.793135 | 7 | 0 | 7 |
| DLG2 | CXCR2 | 0.792886 | 10 | 0 | 10 |
| DLG2 | SFTA2 | 0.792303 | 4 | 0 | 4 |
| DLG2 | EHD3 | 0.790133 | 10 | 0 | 10 |
| DLG2 | GYS2 | 0.788576 | 9 | 0 | 9 |
| DLG2 | ENDOU | 0.787718 | 10 | 0 | 10 |
| DLG2 | C18orf25 | 0.787282 | 10 | 0 | 10 |
For details and further investigation, click here
