| Full name: RAS protein activator like 2 | Alias Symbol: nGAP | ||
| Type: protein-coding gene | Cytoband: 1q25.2 | ||
| Entrez ID: 9462 | HGNC ID: HGNC:9874 | Ensembl Gene: ENSG00000075391 | OMIM ID: 606136 |
| Drug and gene relationship at DGIdb | |||
RASAL2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway |
Expression of RASAL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RASAL2 | 9462 | 222810_s_at | -0.8126 | 0.1435 | |
| GSE20347 | RASAL2 | 9462 | 219026_s_at | -1.5253 | 0.0000 | |
| GSE23400 | RASAL2 | 9462 | 219026_s_at | -1.0625 | 0.0000 | |
| GSE26886 | RASAL2 | 9462 | 222810_s_at | -0.4151 | 0.1814 | |
| GSE29001 | RASAL2 | 9462 | 219026_s_at | -1.5421 | 0.0052 | |
| GSE38129 | RASAL2 | 9462 | 219026_s_at | -0.9674 | 0.0029 | |
| GSE45670 | RASAL2 | 9462 | 222810_s_at | -0.7313 | 0.0050 | |
| GSE53622 | RASAL2 | 9462 | 13568 | -0.7184 | 0.0000 | |
| GSE53624 | RASAL2 | 9462 | 13568 | -1.3996 | 0.0000 | |
| GSE63941 | RASAL2 | 9462 | 222810_s_at | 1.5680 | 0.0066 | |
| GSE77861 | RASAL2 | 9462 | 222810_s_at | -0.3280 | 0.4307 | |
| GSE97050 | RASAL2 | 9462 | A_33_P3350758 | 0.0034 | 0.9954 | |
| SRP007169 | RASAL2 | 9462 | RNAseq | -1.6139 | 0.0000 | |
| SRP008496 | RASAL2 | 9462 | RNAseq | -1.4755 | 0.0000 | |
| SRP064894 | RASAL2 | 9462 | RNAseq | -1.4996 | 0.0000 | |
| SRP133303 | RASAL2 | 9462 | RNAseq | -0.9469 | 0.0000 | |
| SRP159526 | RASAL2 | 9462 | RNAseq | -1.6072 | 0.0000 | |
| SRP193095 | RASAL2 | 9462 | RNAseq | -1.4776 | 0.0000 | |
| SRP219564 | RASAL2 | 9462 | RNAseq | -0.9958 | 0.1071 | |
| TCGA | RASAL2 | 9462 | RNAseq | 0.0490 | 0.4750 |
Upregulated datasets: 1; Downregulated datasets: 9.
Survival by RASAL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RASAL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RASAL2 | 9462 | 12 | 0 | 18 | |
| GSE20123 | RASAL2 | 9462 | 12 | 0 | 18 | |
| GSE43470 | RASAL2 | 9462 | 7 | 1 | 35 | |
| GSE46452 | RASAL2 | 9462 | 3 | 1 | 55 | |
| GSE47630 | RASAL2 | 9462 | 14 | 0 | 26 | |
| GSE54993 | RASAL2 | 9462 | 0 | 6 | 64 | |
| GSE54994 | RASAL2 | 9462 | 15 | 0 | 38 | |
| GSE60625 | RASAL2 | 9462 | 0 | 0 | 11 | |
| GSE74703 | RASAL2 | 9462 | 7 | 1 | 28 | |
| GSE74704 | RASAL2 | 9462 | 5 | 0 | 15 | |
| TCGA | RASAL2 | 9462 | 40 | 3 | 53 |
Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.
Somatic mutations of RASAL2:
Generating mutation plots.
Highly correlated genes for RASAL2:
Showing top 20/1229 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RASAL2 | SPRYD4 | 0.810618 | 3 | 0 | 3 |
| RASAL2 | TECR | 0.761614 | 8 | 0 | 8 |
| RASAL2 | RAB25 | 0.758873 | 10 | 0 | 10 |
| RASAL2 | RMND5B | 0.757704 | 9 | 0 | 9 |
| RASAL2 | SH3GL1 | 0.756335 | 10 | 0 | 9 |
| RASAL2 | SLC46A2 | 0.75606 | 6 | 0 | 6 |
| RASAL2 | ZNF365 | 0.754938 | 9 | 0 | 9 |
| RASAL2 | ARGLU1 | 0.751544 | 3 | 0 | 3 |
| RASAL2 | LMNA | 0.750951 | 3 | 0 | 3 |
| RASAL2 | GYS2 | 0.747272 | 10 | 0 | 9 |
| RASAL2 | FLG | 0.746863 | 9 | 0 | 9 |
| RASAL2 | ELOVL1 | 0.743988 | 3 | 0 | 3 |
| RASAL2 | YOD1 | 0.743701 | 11 | 0 | 10 |
| RASAL2 | IL18 | 0.741301 | 10 | 0 | 9 |
| RASAL2 | NUAK2 | 0.73622 | 3 | 0 | 3 |
| RASAL2 | SNX24 | 0.734572 | 9 | 0 | 8 |
| RASAL2 | ACPP | 0.73374 | 9 | 0 | 8 |
| RASAL2 | MXD1 | 0.733675 | 10 | 0 | 8 |
| RASAL2 | SMAGP | 0.731946 | 10 | 0 | 9 |
| RASAL2 | TOM1 | 0.729676 | 10 | 0 | 8 |
For details and further investigation, click here
