| Full name: serine palmitoyltransferase long chain base subunit 2 | Alias Symbol: KIAA0526|LCB2|LCB2A|hLCB2a | ||
| Type: protein-coding gene | Cytoband: 14q24.3 | ||
| Entrez ID: 9517 | HGNC ID: HGNC:11278 | Ensembl Gene: ENSG00000100596 | OMIM ID: 605713 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SPTLC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPTLC2 | 9517 | 203127_s_at | -0.5725 | 0.3952 | |
| GSE20347 | SPTLC2 | 9517 | 203127_s_at | -0.8817 | 0.0001 | |
| GSE23400 | SPTLC2 | 9517 | 203127_s_at | -0.3433 | 0.0015 | |
| GSE26886 | SPTLC2 | 9517 | 203127_s_at | -0.6719 | 0.0006 | |
| GSE29001 | SPTLC2 | 9517 | 203127_s_at | -0.7851 | 0.0328 | |
| GSE38129 | SPTLC2 | 9517 | 203127_s_at | -0.3491 | 0.1571 | |
| GSE45670 | SPTLC2 | 9517 | 203127_s_at | -0.3178 | 0.1199 | |
| GSE53622 | SPTLC2 | 9517 | 55224 | -0.3560 | 0.0006 | |
| GSE53624 | SPTLC2 | 9517 | 55224 | -0.5842 | 0.0000 | |
| GSE63941 | SPTLC2 | 9517 | 203127_s_at | 0.4658 | 0.3545 | |
| GSE77861 | SPTLC2 | 9517 | 203127_s_at | -0.3718 | 0.4037 | |
| GSE97050 | SPTLC2 | 9517 | A_24_P150486 | -0.0282 | 0.9305 | |
| SRP007169 | SPTLC2 | 9517 | RNAseq | -1.0176 | 0.0078 | |
| SRP008496 | SPTLC2 | 9517 | RNAseq | -1.1726 | 0.0000 | |
| SRP064894 | SPTLC2 | 9517 | RNAseq | -0.6198 | 0.0000 | |
| SRP133303 | SPTLC2 | 9517 | RNAseq | -0.4545 | 0.0008 | |
| SRP159526 | SPTLC2 | 9517 | RNAseq | -0.9967 | 0.0013 | |
| SRP193095 | SPTLC2 | 9517 | RNAseq | -0.8598 | 0.0000 | |
| SRP219564 | SPTLC2 | 9517 | RNAseq | -0.8406 | 0.1002 | |
| TCGA | SPTLC2 | 9517 | RNAseq | -0.1578 | 0.0100 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SPTLC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPTLC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPTLC2 | 9517 | 8 | 3 | 19 | |
| GSE20123 | SPTLC2 | 9517 | 8 | 3 | 19 | |
| GSE43470 | SPTLC2 | 9517 | 8 | 3 | 32 | |
| GSE46452 | SPTLC2 | 9517 | 16 | 3 | 40 | |
| GSE47630 | SPTLC2 | 9517 | 11 | 8 | 21 | |
| GSE54993 | SPTLC2 | 9517 | 3 | 8 | 59 | |
| GSE54994 | SPTLC2 | 9517 | 19 | 4 | 30 | |
| GSE60625 | SPTLC2 | 9517 | 0 | 2 | 9 | |
| GSE74703 | SPTLC2 | 9517 | 7 | 3 | 26 | |
| GSE74704 | SPTLC2 | 9517 | 3 | 3 | 14 | |
| TCGA | SPTLC2 | 9517 | 31 | 16 | 49 |
Total number of gains: 114; Total number of losses: 56; Total Number of normals: 318.
Somatic mutations of SPTLC2:
Generating mutation plots.
Highly correlated genes for SPTLC2:
Showing top 20/1159 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPTLC2 | CCNYL1 | 0.780553 | 3 | 0 | 3 |
| SPTLC2 | ZBTB8OS | 0.7798 | 3 | 0 | 3 |
| SPTLC2 | STOML2 | 0.748135 | 3 | 0 | 3 |
| SPTLC2 | PPM1D | 0.747205 | 3 | 0 | 3 |
| SPTLC2 | TMEM167A | 0.737078 | 3 | 0 | 3 |
| SPTLC2 | AK2 | 0.730631 | 4 | 0 | 4 |
| SPTLC2 | SLC12A6 | 0.710373 | 7 | 0 | 7 |
| SPTLC2 | MPZL3 | 0.709191 | 6 | 0 | 6 |
| SPTLC2 | CPVL | 0.707343 | 3 | 0 | 3 |
| SPTLC2 | ITCH | 0.703354 | 11 | 0 | 10 |
| SPTLC2 | SHMT1 | 0.701615 | 3 | 0 | 3 |
| SPTLC2 | HPSE | 0.700818 | 12 | 0 | 11 |
| SPTLC2 | RALB | 0.700607 | 9 | 0 | 8 |
| SPTLC2 | PLD1 | 0.699829 | 9 | 0 | 8 |
| SPTLC2 | RCOR1 | 0.6983 | 10 | 0 | 9 |
| SPTLC2 | ANKHD1 | 0.697088 | 3 | 0 | 3 |
| SPTLC2 | STXBP5 | 0.696042 | 5 | 0 | 4 |
| SPTLC2 | RNF146 | 0.694708 | 3 | 0 | 3 |
| SPTLC2 | CCDC25 | 0.694202 | 3 | 0 | 3 |
| SPTLC2 | ZDHHC13 | 0.691168 | 9 | 0 | 9 |
For details and further investigation, click here
