| Full name: serine hydroxymethyltransferase 1 | Alias Symbol: CSHMT|SHMT|MGC15229|MGC24556 | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 6470 | HGNC ID: HGNC:10850 | Ensembl Gene: ENSG00000176974 | OMIM ID: 182144 |
| Drug and gene relationship at DGIdb | |||
Expression of SHMT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHMT1 | 6470 | 231701_s_at | -0.2205 | 0.3685 | |
| GSE20347 | SHMT1 | 6470 | 217304_at | 0.0689 | 0.2891 | |
| GSE23400 | SHMT1 | 6470 | 217304_at | 0.0478 | 0.0683 | |
| GSE26886 | SHMT1 | 6470 | 231701_s_at | -0.2268 | 0.1987 | |
| GSE29001 | SHMT1 | 6470 | 217304_at | 0.1192 | 0.4746 | |
| GSE38129 | SHMT1 | 6470 | 217304_at | 0.0457 | 0.4525 | |
| GSE45670 | SHMT1 | 6470 | 231701_s_at | -0.2470 | 0.1217 | |
| GSE53622 | SHMT1 | 6470 | 57754 | -0.3295 | 0.0000 | |
| GSE53624 | SHMT1 | 6470 | 57754 | -0.1213 | 0.0037 | |
| GSE63941 | SHMT1 | 6470 | 231701_s_at | 0.3433 | 0.1795 | |
| GSE77861 | SHMT1 | 6470 | 217304_at | 0.0824 | 0.5821 | |
| GSE97050 | SHMT1 | 6470 | A_23_P502654 | -0.4231 | 0.2909 | |
| SRP007169 | SHMT1 | 6470 | RNAseq | -2.0013 | 0.0005 | |
| SRP008496 | SHMT1 | 6470 | RNAseq | -1.9679 | 0.0000 | |
| SRP064894 | SHMT1 | 6470 | RNAseq | -1.0555 | 0.0000 | |
| SRP133303 | SHMT1 | 6470 | RNAseq | -1.5164 | 0.0000 | |
| SRP159526 | SHMT1 | 6470 | RNAseq | -1.3807 | 0.0001 | |
| SRP193095 | SHMT1 | 6470 | RNAseq | -1.5085 | 0.0000 | |
| SRP219564 | SHMT1 | 6470 | RNAseq | -1.4250 | 0.0080 | |
| TCGA | SHMT1 | 6470 | RNAseq | 0.0328 | 0.6591 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by SHMT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHMT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHMT1 | 6470 | 3 | 3 | 24 | |
| GSE20123 | SHMT1 | 6470 | 3 | 4 | 23 | |
| GSE43470 | SHMT1 | 6470 | 1 | 5 | 37 | |
| GSE46452 | SHMT1 | 6470 | 34 | 1 | 24 | |
| GSE47630 | SHMT1 | 6470 | 7 | 1 | 32 | |
| GSE54993 | SHMT1 | 6470 | 3 | 3 | 64 | |
| GSE54994 | SHMT1 | 6470 | 6 | 6 | 41 | |
| GSE60625 | SHMT1 | 6470 | 4 | 0 | 7 | |
| GSE74703 | SHMT1 | 6470 | 1 | 2 | 33 | |
| GSE74704 | SHMT1 | 6470 | 2 | 1 | 17 | |
| TCGA | SHMT1 | 6470 | 19 | 23 | 54 |
Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.
Somatic mutations of SHMT1:
Generating mutation plots.
Highly correlated genes for SHMT1:
Showing top 20/222 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHMT1 | SMPD2 | 0.705847 | 3 | 0 | 3 |
| SHMT1 | MPP7 | 0.702627 | 4 | 0 | 4 |
| SHMT1 | SPTLC2 | 0.701615 | 3 | 0 | 3 |
| SHMT1 | CAPNS2 | 0.689997 | 3 | 0 | 3 |
| SHMT1 | HAUS2 | 0.687074 | 4 | 0 | 4 |
| SHMT1 | RMND5B | 0.681469 | 4 | 0 | 4 |
| SHMT1 | SPINT1 | 0.674956 | 3 | 0 | 3 |
| SHMT1 | FAM110C | 0.671835 | 4 | 0 | 4 |
| SHMT1 | ABI1 | 0.670935 | 3 | 0 | 3 |
| SHMT1 | CMPK1 | 0.670511 | 4 | 0 | 4 |
| SHMT1 | DOCK9 | 0.665759 | 4 | 0 | 4 |
| SHMT1 | ABR | 0.659824 | 3 | 0 | 3 |
| SHMT1 | ANKRD37 | 0.64934 | 4 | 0 | 3 |
| SHMT1 | YTHDC2 | 0.649001 | 4 | 0 | 3 |
| SHMT1 | SERPINB11 | 0.648756 | 4 | 0 | 3 |
| SHMT1 | RASGEF1B | 0.647157 | 3 | 0 | 3 |
| SHMT1 | USP6NL | 0.644503 | 4 | 0 | 3 |
| SHMT1 | RBFA | 0.641601 | 3 | 0 | 3 |
| SHMT1 | HSD17B4 | 0.641269 | 4 | 0 | 3 |
| SHMT1 | TRIP10 | 0.636674 | 5 | 0 | 5 |
For details and further investigation, click here
