| Full name: serine palmitoyltransferase small subunit B | Alias Symbol: ADMP|ssSPTb | ||
| Type: protein-coding gene | Cytoband: 3q26.1 | ||
| Entrez ID: 165679 | HGNC ID: HGNC:24045 | Ensembl Gene: ENSG00000196542 | OMIM ID: 610412 |
| Drug and gene relationship at DGIdb | |||
Expression of SPTSSB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPTSSB | 165679 | 238702_at | -0.2764 | 0.2230 | |
| GSE26886 | SPTSSB | 165679 | 238702_at | -0.7074 | 0.0020 | |
| GSE45670 | SPTSSB | 165679 | 238702_at | -0.3113 | 0.0674 | |
| GSE53622 | SPTSSB | 165679 | 35711 | -1.6284 | 0.0000 | |
| GSE53624 | SPTSSB | 165679 | 35711 | -2.7747 | 0.0000 | |
| GSE63941 | SPTSSB | 165679 | 238702_at | 0.5485 | 0.2302 | |
| GSE77861 | SPTSSB | 165679 | 238702_at | -0.0842 | 0.5808 | |
| GSE97050 | SPTSSB | 165679 | A_32_P199551 | 0.0551 | 0.9635 | |
| SRP007169 | SPTSSB | 165679 | RNAseq | -3.6481 | 0.0000 | |
| SRP008496 | SPTSSB | 165679 | RNAseq | -2.5841 | 0.0010 | |
| SRP064894 | SPTSSB | 165679 | RNAseq | -1.5519 | 0.0030 | |
| SRP133303 | SPTSSB | 165679 | RNAseq | -0.5531 | 0.4201 | |
| SRP159526 | SPTSSB | 165679 | RNAseq | -0.0905 | 0.8971 | |
| SRP193095 | SPTSSB | 165679 | RNAseq | -2.7772 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by SPTSSB expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SPTSSB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPTSSB | 165679 | 22 | 0 | 8 | |
| GSE20123 | SPTSSB | 165679 | 22 | 0 | 8 | |
| GSE43470 | SPTSSB | 165679 | 23 | 0 | 20 | |
| GSE46452 | SPTSSB | 165679 | 18 | 2 | 39 | |
| GSE47630 | SPTSSB | 165679 | 19 | 3 | 18 | |
| GSE54993 | SPTSSB | 165679 | 1 | 11 | 58 | |
| GSE54994 | SPTSSB | 165679 | 38 | 1 | 14 | |
| GSE60625 | SPTSSB | 165679 | 0 | 6 | 5 | |
| GSE74703 | SPTSSB | 165679 | 20 | 0 | 16 | |
| GSE74704 | SPTSSB | 165679 | 14 | 0 | 6 | |
| TCGA | SPTSSB | 165679 | 77 | 0 | 19 |
Total number of gains: 254; Total number of losses: 23; Total Number of normals: 211.
Somatic mutations of SPTSSB:
Generating mutation plots.
Highly correlated genes for SPTSSB:
Showing top 20/622 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPTSSB | CYP2C9 | 0.709593 | 4 | 0 | 4 |
| SPTSSB | ATP13A4 | 0.70856 | 6 | 0 | 5 |
| SPTSSB | DNASE1L3 | 0.708553 | 5 | 0 | 5 |
| SPTSSB | TCN1 | 0.70437 | 5 | 0 | 5 |
| SPTSSB | CEACAM1 | 0.697569 | 4 | 0 | 4 |
| SPTSSB | CYP2C18 | 0.696371 | 4 | 0 | 4 |
| SPTSSB | SERPINB3 | 0.69384 | 3 | 0 | 3 |
| SPTSSB | SPINK7 | 0.693303 | 4 | 0 | 3 |
| SPTSSB | TEX101 | 0.692833 | 3 | 0 | 3 |
| SPTSSB | TST | 0.691932 | 6 | 0 | 6 |
| SPTSSB | PIM1 | 0.687713 | 3 | 0 | 3 |
| SPTSSB | RDH12 | 0.68009 | 6 | 0 | 5 |
| SPTSSB | TIAM1 | 0.678288 | 5 | 0 | 5 |
| SPTSSB | ATP6V1C2 | 0.6774 | 3 | 0 | 3 |
| SPTSSB | CPT2 | 0.676687 | 3 | 0 | 3 |
| SPTSSB | TTC9 | 0.675298 | 7 | 0 | 6 |
| SPTSSB | GLTP | 0.675011 | 4 | 0 | 3 |
| SPTSSB | KLHDC8A | 0.672871 | 5 | 0 | 4 |
| SPTSSB | FAM214A | 0.671315 | 4 | 0 | 4 |
| SPTSSB | ABHD12 | 0.670116 | 4 | 0 | 4 |
For details and further investigation, click here
