| Full name: serpin family B member 3 | Alias Symbol: T4-A|HsT1196 | ||
| Type: protein-coding gene | Cytoband: 18q21.33 | ||
| Entrez ID: 6317 | HGNC ID: HGNC:10569 | Ensembl Gene: ENSG00000057149 | OMIM ID: 600517 |
| Drug and gene relationship at DGIdb | |||
Expression of SERPINB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINB3 | 6317 | 209719_x_at | -2.8145 | 0.2965 | |
| GSE20347 | SERPINB3 | 6317 | 209719_x_at | -3.3473 | 0.0001 | |
| GSE23400 | SERPINB3 | 6317 | 209719_x_at | -2.4722 | 0.0000 | |
| GSE26886 | SERPINB3 | 6317 | 209719_x_at | -5.4503 | 0.0000 | |
| GSE29001 | SERPINB3 | 6317 | 209719_x_at | -3.6222 | 0.0000 | |
| GSE38129 | SERPINB3 | 6317 | 209719_x_at | -1.5576 | 0.0951 | |
| GSE45670 | SERPINB3 | 6317 | 209719_x_at | -0.2804 | 0.4507 | |
| GSE63941 | SERPINB3 | 6317 | 209719_x_at | 2.3194 | 0.1882 | |
| GSE77861 | SERPINB3 | 6317 | 209719_x_at | -1.2636 | 0.0233 | |
| GSE97050 | SERPINB3 | 6317 | A_23_P55632 | -0.2711 | 0.8604 | |
| SRP007169 | SERPINB3 | 6317 | RNAseq | -6.6973 | 0.0000 | |
| SRP008496 | SERPINB3 | 6317 | RNAseq | -3.6650 | 0.0000 | |
| SRP064894 | SERPINB3 | 6317 | RNAseq | -3.5727 | 0.0000 | |
| SRP133303 | SERPINB3 | 6317 | RNAseq | -2.6842 | 0.0000 | |
| SRP159526 | SERPINB3 | 6317 | RNAseq | -2.2857 | 0.0435 | |
| SRP219564 | SERPINB3 | 6317 | RNAseq | -2.4695 | 0.0395 | |
| TCGA | SERPINB3 | 6317 | RNAseq | 0.9739 | 0.0156 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by SERPINB3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SERPINB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINB3 | 6317 | 1 | 9 | 20 | |
| GSE20123 | SERPINB3 | 6317 | 1 | 9 | 20 | |
| GSE43470 | SERPINB3 | 6317 | 0 | 7 | 36 | |
| GSE46452 | SERPINB3 | 6317 | 1 | 26 | 32 | |
| GSE47630 | SERPINB3 | 6317 | 5 | 21 | 14 | |
| GSE54993 | SERPINB3 | 6317 | 9 | 0 | 61 | |
| GSE54994 | SERPINB3 | 6317 | 1 | 18 | 34 | |
| GSE60625 | SERPINB3 | 6317 | 0 | 4 | 7 | |
| GSE74703 | SERPINB3 | 6317 | 0 | 7 | 29 | |
| GSE74704 | SERPINB3 | 6317 | 1 | 6 | 13 | |
| TCGA | SERPINB3 | 6317 | 10 | 45 | 41 |
Total number of gains: 29; Total number of losses: 152; Total Number of normals: 307.
Somatic mutations of SERPINB3:
Generating mutation plots.
Highly correlated genes for SERPINB3:
Showing top 20/1073 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINB3 | SERPINB4 | 0.87642 | 11 | 0 | 11 |
| SERPINB3 | IL20RB | 0.845327 | 4 | 0 | 4 |
| SERPINB3 | SCEL | 0.802573 | 10 | 0 | 10 |
| SERPINB3 | TMPRSS11E | 0.791549 | 10 | 0 | 9 |
| SERPINB3 | CERS3 | 0.787096 | 4 | 0 | 4 |
| SERPINB3 | SERPINB13 | 0.780458 | 11 | 0 | 11 |
| SERPINB3 | CLIC3 | 0.780193 | 10 | 0 | 10 |
| SERPINB3 | RHCG | 0.777747 | 10 | 0 | 10 |
| SERPINB3 | PPL | 0.770344 | 10 | 0 | 10 |
| SERPINB3 | CXCR2 | 0.76922 | 7 | 0 | 7 |
| SERPINB3 | FMO2 | 0.765813 | 8 | 0 | 8 |
| SERPINB3 | CYSRT1 | 0.765635 | 4 | 0 | 4 |
| SERPINB3 | RAB11A | 0.764918 | 8 | 0 | 8 |
| SERPINB3 | TGM1 | 0.764143 | 11 | 0 | 10 |
| SERPINB3 | KLK13 | 0.76277 | 11 | 0 | 10 |
| SERPINB3 | TMPRSS11D | 0.761227 | 10 | 0 | 9 |
| SERPINB3 | SPINK5 | 0.760059 | 10 | 0 | 10 |
| SERPINB3 | SULT2B1 | 0.759845 | 10 | 0 | 9 |
| SERPINB3 | SH3PXD2A-AS1 | 0.755992 | 4 | 0 | 4 |
| SERPINB3 | MUC17 | 0.754275 | 3 | 0 | 3 |
For details and further investigation, click here
