| Full name: transcobalamin 1 | Alias Symbol: TCI|TC1 | ||
| Type: protein-coding gene | Cytoband: 11q12.1 | ||
| Entrez ID: 6947 | HGNC ID: HGNC:11652 | Ensembl Gene: ENSG00000134827 | OMIM ID: 189905 |
| Drug and gene relationship at DGIdb | |||
Expression of TCN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TCN1 | 6947 | 205513_at | -1.9810 | 0.1490 | |
| GSE20347 | TCN1 | 6947 | 205513_at | -1.9957 | 0.0001 | |
| GSE23400 | TCN1 | 6947 | 205513_at | -1.0104 | 0.0000 | |
| GSE26886 | TCN1 | 6947 | 205513_at | -3.4619 | 0.0000 | |
| GSE29001 | TCN1 | 6947 | 205513_at | -1.5394 | 0.0193 | |
| GSE38129 | TCN1 | 6947 | 205513_at | -2.0098 | 0.0000 | |
| GSE45670 | TCN1 | 6947 | 205513_at | -0.2521 | 0.8100 | |
| GSE53622 | TCN1 | 6947 | 124623 | -3.6875 | 0.0000 | |
| GSE53624 | TCN1 | 6947 | 124623 | -3.6839 | 0.0000 | |
| GSE63941 | TCN1 | 6947 | 205513_at | 0.7363 | 0.4697 | |
| GSE77861 | TCN1 | 6947 | 205513_at | -2.6056 | 0.0025 | |
| GSE97050 | TCN1 | 6947 | A_23_P64372 | -0.1679 | 0.6528 | |
| SRP007169 | TCN1 | 6947 | RNAseq | -2.8331 | 0.1721 | |
| SRP008496 | TCN1 | 6947 | RNAseq | -3.1727 | 0.0016 | |
| SRP064894 | TCN1 | 6947 | RNAseq | -4.4698 | 0.0000 | |
| SRP133303 | TCN1 | 6947 | RNAseq | -3.2230 | 0.0000 | |
| SRP159526 | TCN1 | 6947 | RNAseq | -2.5668 | 0.0122 | |
| SRP193095 | TCN1 | 6947 | RNAseq | -1.5363 | 0.0057 | |
| SRP219564 | TCN1 | 6947 | RNAseq | 0.0787 | 0.9517 | |
| TCGA | TCN1 | 6947 | RNAseq | -1.2537 | 0.0494 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by TCN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TCN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TCN1 | 6947 | 1 | 5 | 24 | |
| GSE20123 | TCN1 | 6947 | 1 | 5 | 24 | |
| GSE43470 | TCN1 | 6947 | 2 | 5 | 36 | |
| GSE46452 | TCN1 | 6947 | 9 | 4 | 46 | |
| GSE47630 | TCN1 | 6947 | 3 | 8 | 29 | |
| GSE54993 | TCN1 | 6947 | 3 | 0 | 67 | |
| GSE54994 | TCN1 | 6947 | 6 | 5 | 42 | |
| GSE60625 | TCN1 | 6947 | 0 | 3 | 8 | |
| GSE74703 | TCN1 | 6947 | 2 | 3 | 31 | |
| GSE74704 | TCN1 | 6947 | 1 | 4 | 15 | |
| TCGA | TCN1 | 6947 | 14 | 10 | 72 |
Total number of gains: 42; Total number of losses: 52; Total Number of normals: 394.
Somatic mutations of TCN1:
Generating mutation plots.
Highly correlated genes for TCN1:
Showing top 20/1163 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TCN1 | SNORA68 | 0.743448 | 3 | 0 | 3 |
| TCN1 | SPAG17 | 0.732774 | 6 | 0 | 5 |
| TCN1 | CXCR2 | 0.73023 | 9 | 0 | 9 |
| TCN1 | TBC1D20 | 0.721898 | 3 | 0 | 3 |
| TCN1 | FMO2 | 0.707803 | 10 | 0 | 10 |
| TCN1 | PRSS27 | 0.707562 | 7 | 0 | 6 |
| TCN1 | FCHO2 | 0.706531 | 6 | 0 | 5 |
| TCN1 | LRRC26 | 0.70503 | 3 | 0 | 3 |
| TCN1 | SPTSSB | 0.70437 | 5 | 0 | 5 |
| TCN1 | FAM3D | 0.704248 | 9 | 0 | 7 |
| TCN1 | CAPN14 | 0.702128 | 7 | 0 | 6 |
| TCN1 | ATP13A4 | 0.701234 | 8 | 0 | 8 |
| TCN1 | LINC00551 | 0.700884 | 3 | 0 | 3 |
| TCN1 | PLAC8 | 0.700636 | 10 | 0 | 10 |
| TCN1 | C12orf74 | 0.69651 | 3 | 0 | 3 |
| TCN1 | TP53I3 | 0.693178 | 10 | 0 | 10 |
| TCN1 | FAM3B | 0.693043 | 7 | 0 | 6 |
| TCN1 | MCEE | 0.691116 | 5 | 0 | 5 |
| TCN1 | SFTA2 | 0.689481 | 5 | 0 | 4 |
| TCN1 | CTTNBP2 | 0.6891 | 5 | 0 | 5 |
For details and further investigation, click here
