PIM1

 

Full name: Pim-1 proto-oncogene, serine/threonine kinase Alias Symbol: 
Type: protein-coding gene Cytoband: 6p21.2
Entrez ID: 5292 HGNC ID: HGNC:8986 Ensembl Gene: ENSG00000137193 OMIM ID: 164960
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 14/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PIM1 involved pathways:

KEGG pathway Description View
hsa04630Jak-STAT signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05221Acute myeloid leukemia

 

Expression of PIM1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PIM1 5292 209193_at -1.2715 0.0362
GSE20347 PIM1 5292 209193_at -1.3713 0.0000
GSE23400 PIM1 5292 209193_at -1.3042 0.0000
GSE26886 PIM1 5292 209193_at -2.5048 0.0000
GSE29001 PIM1 5292 209193_at -1.7886 0.0001
GSE38129 PIM1 5292 209193_at -1.0367 0.0000
GSE45670 PIM1 5292 209193_at -0.6297 0.0304
GSE53622 PIM1 5292 34076 -1.6153 0.0000
GSE53624 PIM1 5292 34076 -1.5377 0.0000
GSE63941 PIM1 5292 209193_at -0.2855 0.6484
GSE77861 PIM1 5292 209193_at -1.1500 0.0003
GSE97050 PIM1 5292 A_23_P345118 -0.7832 0.1242
SRP007169 PIM1 5292 RNAseq -4.2120 0.0000
SRP008496 PIM1 5292 RNAseq -3.8851 0.0000
SRP064894 PIM1 5292 RNAseq -1.9226 0.0000
SRP133303 PIM1 5292 RNAseq -1.7714 0.0000
SRP159526 PIM1 5292 RNAseq -2.7047 0.0000
SRP193095 PIM1 5292 RNAseq -1.8377 0.0000
SRP219564 PIM1 5292 RNAseq -1.9088 0.0001
TCGA PIM1 5292 RNAseq 0.0047 0.9571

Upregulated datasets: 0; Downregulated datasets: 16.  

 

Survival by PIM1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PIM1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PIM1 5292 6 0 24
GSE20123 PIM1 5292 6 0 24
GSE43470 PIM1 5292 5 1 37
GSE46452 PIM1 5292 2 9 48
GSE47630 PIM1 5292 8 4 28
GSE54993 PIM1 5292 3 1 66
GSE54994 PIM1 5292 10 5 38
GSE60625 PIM1 5292 1 0 10
GSE74703 PIM1 5292 5 0 31
GSE74704 PIM1 5292 3 0 17
TCGA PIM1 5292 16 14 66

Total number of gains: 65; Total number of losses: 34; Total Number of normals: 389.  

 

Somatic mutations of PIM1:

 

Generating mutation plots.

 

Highly correlated genes for PIM1:

 

Showing top 20/1791 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PIM1TRIP100.85908411011
PIM1GDPD30.8532110010
PIM1CYSRT10.850766606
PIM1ECM10.84865310010
PIM1EVPL0.84795810010
PIM1SCNN1B0.84114710010
PIM1VSIG10L0.838043606
PIM1FCHO20.836328707
PIM1IL1RN0.83237710010
PIM1PRSS270.830871606
PIM1PADI10.82991808
PIM1SNORA680.82868404
PIM1ALS2CL0.82663610010
PIM1CRCT10.82546311010
PIM1DUSP50.82504211011
PIM1MALL0.82368911010
PIM1GYS20.8173810010
PIM1NLRX10.81345610010
PIM1SH3GL10.81186111011
PIM1TOM10.8104811011

For details and further investigation, click here