| Full name: kelch domain containing 8A | Alias Symbol: FLJ10748 | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 55220 | HGNC ID: HGNC:25573 | Ensembl Gene: ENSG00000162873 | OMIM ID: 614503 |
| Drug and gene relationship at DGIdb | |||
Expression of KLHDC8A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHDC8A | 55220 | 222871_at | -0.8390 | 0.0863 | |
| GSE20347 | KLHDC8A | 55220 | 219331_s_at | -0.5202 | 0.0001 | |
| GSE23400 | KLHDC8A | 55220 | 219331_s_at | -0.4901 | 0.0000 | |
| GSE26886 | KLHDC8A | 55220 | 222871_at | -1.5325 | 0.0001 | |
| GSE29001 | KLHDC8A | 55220 | 219331_s_at | -0.3284 | 0.0778 | |
| GSE38129 | KLHDC8A | 55220 | 219331_s_at | -0.5233 | 0.0000 | |
| GSE45670 | KLHDC8A | 55220 | 222871_at | -0.6645 | 0.1708 | |
| GSE53622 | KLHDC8A | 55220 | 107921 | -2.3966 | 0.0000 | |
| GSE53624 | KLHDC8A | 55220 | 107921 | -2.8748 | 0.0000 | |
| GSE63941 | KLHDC8A | 55220 | 222871_at | 0.5759 | 0.1657 | |
| GSE77861 | KLHDC8A | 55220 | 222871_at | -0.4624 | 0.0019 | |
| GSE97050 | KLHDC8A | 55220 | A_24_P62800 | 0.1897 | 0.4983 | |
| SRP007169 | KLHDC8A | 55220 | RNAseq | -4.9589 | 0.0000 | |
| SRP008496 | KLHDC8A | 55220 | RNAseq | -5.1424 | 0.0000 | |
| SRP064894 | KLHDC8A | 55220 | RNAseq | -2.7880 | 0.0000 | |
| SRP133303 | KLHDC8A | 55220 | RNAseq | -2.6191 | 0.0000 | |
| SRP159526 | KLHDC8A | 55220 | RNAseq | -2.3190 | 0.0000 | |
| SRP219564 | KLHDC8A | 55220 | RNAseq | -3.4234 | 0.0000 | |
| TCGA | KLHDC8A | 55220 | RNAseq | -1.4540 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by KLHDC8A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHDC8A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHDC8A | 55220 | 11 | 0 | 19 | |
| GSE20123 | KLHDC8A | 55220 | 11 | 0 | 19 | |
| GSE43470 | KLHDC8A | 55220 | 6 | 0 | 37 | |
| GSE46452 | KLHDC8A | 55220 | 3 | 1 | 55 | |
| GSE47630 | KLHDC8A | 55220 | 14 | 0 | 26 | |
| GSE54993 | KLHDC8A | 55220 | 0 | 6 | 64 | |
| GSE54994 | KLHDC8A | 55220 | 15 | 0 | 38 | |
| GSE60625 | KLHDC8A | 55220 | 0 | 0 | 11 | |
| GSE74703 | KLHDC8A | 55220 | 6 | 0 | 30 | |
| GSE74704 | KLHDC8A | 55220 | 5 | 0 | 15 | |
| TCGA | KLHDC8A | 55220 | 43 | 4 | 49 |
Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.
Somatic mutations of KLHDC8A:
Generating mutation plots.
Highly correlated genes for KLHDC8A:
Showing top 20/1407 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHDC8A | KRT78 | 0.754659 | 6 | 0 | 6 |
| KLHDC8A | KLB | 0.753843 | 6 | 0 | 6 |
| KLHDC8A | LTA4H | 0.752189 | 3 | 0 | 3 |
| KLHDC8A | MAPK3 | 0.748945 | 11 | 0 | 11 |
| KLHDC8A | GDPD3 | 0.746767 | 11 | 0 | 11 |
| KLHDC8A | SLC10A5 | 0.744986 | 3 | 0 | 3 |
| KLHDC8A | SLC7A4 | 0.743576 | 8 | 0 | 8 |
| KLHDC8A | PRSS27 | 0.739475 | 6 | 0 | 6 |
| KLHDC8A | ATP13A4 | 0.736628 | 7 | 0 | 7 |
| KLHDC8A | IQCF1 | 0.732666 | 3 | 0 | 3 |
| KLHDC8A | CYSRT1 | 0.730953 | 6 | 0 | 6 |
| KLHDC8A | UPK3B | 0.730841 | 3 | 0 | 3 |
| KLHDC8A | SPINK7 | 0.730654 | 6 | 0 | 6 |
| KLHDC8A | HCG22 | 0.727205 | 6 | 0 | 6 |
| KLHDC8A | SLURP1 | 0.724787 | 10 | 0 | 10 |
| KLHDC8A | CAPN14 | 0.719555 | 6 | 0 | 6 |
| KLHDC8A | TMEM45B | 0.714281 | 7 | 0 | 7 |
| KLHDC8A | SH3PXD2A-AS1 | 0.712941 | 4 | 0 | 4 |
| KLHDC8A | GYS2 | 0.712646 | 10 | 0 | 10 |
| KLHDC8A | SCNN1B | 0.711118 | 11 | 0 | 11 |
For details and further investigation, click here
