| Full name: Snf2 related CREBBP activator protein | Alias Symbol: KIAA0309|EAF1|SWR1|DOMO1 | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 10847 | HGNC ID: HGNC:16974 | Ensembl Gene: ENSG00000080603 | OMIM ID: 611421 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SRCAP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRCAP | 10847 | 212275_s_at | 0.1394 | 0.6767 | |
| GSE20347 | SRCAP | 10847 | 212275_s_at | -0.0335 | 0.7039 | |
| GSE23400 | SRCAP | 10847 | 215053_at | -0.1256 | 0.0005 | |
| GSE26886 | SRCAP | 10847 | 212275_s_at | 0.2208 | 0.0660 | |
| GSE29001 | SRCAP | 10847 | 212275_s_at | -0.3274 | 0.0824 | |
| GSE38129 | SRCAP | 10847 | 212275_s_at | 0.0070 | 0.9300 | |
| GSE45670 | SRCAP | 10847 | 212275_s_at | -0.0392 | 0.6908 | |
| GSE53622 | SRCAP | 10847 | 96742 | -0.5830 | 0.0000 | |
| GSE53624 | SRCAP | 10847 | 96742 | -0.7321 | 0.0000 | |
| GSE63941 | SRCAP | 10847 | 212275_s_at | 0.0564 | 0.7887 | |
| GSE77861 | SRCAP | 10847 | 212275_s_at | 0.0205 | 0.8976 | |
| GSE97050 | SRCAP | 10847 | A_23_P394917 | -0.3677 | 0.2959 | |
| SRP007169 | SRCAP | 10847 | RNAseq | 1.0101 | 0.0215 | |
| SRP008496 | SRCAP | 10847 | RNAseq | 0.9331 | 0.0020 | |
| SRP064894 | SRCAP | 10847 | RNAseq | 0.0323 | 0.8787 | |
| SRP133303 | SRCAP | 10847 | RNAseq | 0.2344 | 0.2094 | |
| SRP159526 | SRCAP | 10847 | RNAseq | 0.2278 | 0.2459 | |
| SRP193095 | SRCAP | 10847 | RNAseq | 0.3070 | 0.0355 | |
| SRP219564 | SRCAP | 10847 | RNAseq | 0.1190 | 0.5819 | |
| TCGA | SRCAP | 10847 | RNAseq | -0.0303 | 0.4257 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SRCAP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRCAP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRCAP | 10847 | 5 | 5 | 20 | |
| GSE20123 | SRCAP | 10847 | 5 | 4 | 21 | |
| GSE43470 | SRCAP | 10847 | 3 | 3 | 37 | |
| GSE46452 | SRCAP | 10847 | 38 | 1 | 20 | |
| GSE47630 | SRCAP | 10847 | 11 | 7 | 22 | |
| GSE54993 | SRCAP | 10847 | 2 | 5 | 63 | |
| GSE54994 | SRCAP | 10847 | 5 | 9 | 39 | |
| GSE60625 | SRCAP | 10847 | 4 | 0 | 7 | |
| GSE74703 | SRCAP | 10847 | 3 | 2 | 31 | |
| GSE74704 | SRCAP | 10847 | 3 | 2 | 15 | |
| TCGA | SRCAP | 10847 | 20 | 10 | 66 |
Total number of gains: 99; Total number of losses: 48; Total Number of normals: 341.
Somatic mutations of SRCAP:
Generating mutation plots.
Highly correlated genes for SRCAP:
Showing top 20/466 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRCAP | CSTL1 | 0.777994 | 3 | 0 | 3 |
| SRCAP | OR10G8 | 0.774635 | 3 | 0 | 3 |
| SRCAP | TMEM102 | 0.754342 | 3 | 0 | 3 |
| SRCAP | SPRED3 | 0.742971 | 4 | 0 | 3 |
| SRCAP | KLHL10 | 0.742612 | 3 | 0 | 3 |
| SRCAP | NR1I3 | 0.734413 | 3 | 0 | 3 |
| SRCAP | MATN1 | 0.731066 | 3 | 0 | 3 |
| SRCAP | TSPAN10 | 0.727876 | 3 | 0 | 3 |
| SRCAP | SLC22A11 | 0.719196 | 4 | 0 | 4 |
| SRCAP | MIXL1 | 0.713414 | 3 | 0 | 3 |
| SRCAP | LMAN1L | 0.705456 | 3 | 0 | 3 |
| SRCAP | C19orf81 | 0.70531 | 3 | 0 | 3 |
| SRCAP | OR2Z1 | 0.705051 | 3 | 0 | 3 |
| SRCAP | C20orf141 | 0.702078 | 4 | 0 | 4 |
| SRCAP | CCNJL | 0.701663 | 3 | 0 | 3 |
| SRCAP | NKAIN4 | 0.697472 | 3 | 0 | 3 |
| SRCAP | MYO1A | 0.69538 | 3 | 0 | 3 |
| SRCAP | CLDN14 | 0.69454 | 4 | 0 | 4 |
| SRCAP | SLC6A13 | 0.692322 | 4 | 0 | 3 |
| SRCAP | FCN2 | 0.692124 | 5 | 0 | 4 |
For details and further investigation, click here
