| Full name: sorting nexin 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q13.1 | ||
| Entrez ID: 58533 | HGNC ID: HGNC:14970 | Ensembl Gene: ENSG00000129515 | OMIM ID: 606098 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SNX6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SNX6 | 58533 | 222410_s_at | 0.4474 | 0.6112 | |
| GSE20347 | SNX6 | 58533 | 217789_at | 0.4614 | 0.0188 | |
| GSE23400 | SNX6 | 58533 | 217789_at | 0.3704 | 0.0000 | |
| GSE26886 | SNX6 | 58533 | 222410_s_at | 0.0566 | 0.8180 | |
| GSE29001 | SNX6 | 58533 | 217789_at | 0.3949 | 0.0543 | |
| GSE38129 | SNX6 | 58533 | 217789_at | 0.3680 | 0.0147 | |
| GSE45670 | SNX6 | 58533 | 222410_s_at | 0.1992 | 0.0602 | |
| GSE53622 | SNX6 | 58533 | 103766 | 0.5500 | 0.0000 | |
| GSE53624 | SNX6 | 58533 | 103766 | 0.4143 | 0.0000 | |
| GSE63941 | SNX6 | 58533 | 222410_s_at | 0.4730 | 0.2757 | |
| GSE77861 | SNX6 | 58533 | 222410_s_at | 0.0925 | 0.8332 | |
| GSE97050 | SNX6 | 58533 | A_23_P54000 | 0.5940 | 0.1118 | |
| SRP007169 | SNX6 | 58533 | RNAseq | 0.9364 | 0.0273 | |
| SRP008496 | SNX6 | 58533 | RNAseq | 0.7864 | 0.0075 | |
| SRP064894 | SNX6 | 58533 | RNAseq | 0.4437 | 0.0001 | |
| SRP133303 | SNX6 | 58533 | RNAseq | 0.7406 | 0.0000 | |
| SRP159526 | SNX6 | 58533 | RNAseq | -0.0261 | 0.9122 | |
| SRP193095 | SNX6 | 58533 | RNAseq | -0.0413 | 0.7846 | |
| SRP219564 | SNX6 | 58533 | RNAseq | 0.2370 | 0.3237 | |
| TCGA | SNX6 | 58533 | RNAseq | 0.0926 | 0.0611 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SNX6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SNX6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SNX6 | 58533 | 10 | 4 | 16 | |
| GSE20123 | SNX6 | 58533 | 11 | 4 | 15 | |
| GSE43470 | SNX6 | 58533 | 9 | 2 | 32 | |
| GSE46452 | SNX6 | 58533 | 18 | 2 | 39 | |
| GSE47630 | SNX6 | 58533 | 11 | 10 | 19 | |
| GSE54993 | SNX6 | 58533 | 3 | 10 | 57 | |
| GSE54994 | SNX6 | 58533 | 19 | 5 | 29 | |
| GSE60625 | SNX6 | 58533 | 0 | 2 | 9 | |
| GSE74703 | SNX6 | 58533 | 8 | 2 | 26 | |
| GSE74704 | SNX6 | 58533 | 5 | 3 | 12 | |
| TCGA | SNX6 | 58533 | 33 | 14 | 49 |
Total number of gains: 127; Total number of losses: 58; Total Number of normals: 303.
Somatic mutations of SNX6:
Generating mutation plots.
Highly correlated genes for SNX6:
Showing top 20/412 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SNX6 | SLC37A3 | 0.795004 | 3 | 0 | 3 |
| SNX6 | NOSIP | 0.777297 | 3 | 0 | 3 |
| SNX6 | SRP54 | 0.77381 | 10 | 0 | 10 |
| SNX6 | ZNF808 | 0.76256 | 3 | 0 | 3 |
| SNX6 | RRAGC | 0.75318 | 3 | 0 | 3 |
| SNX6 | TRAPPC6B | 0.727149 | 4 | 0 | 4 |
| SNX6 | C2orf76 | 0.72567 | 3 | 0 | 3 |
| SNX6 | PTPMT1 | 0.715598 | 3 | 0 | 3 |
| SNX6 | RAB21 | 0.712696 | 3 | 0 | 3 |
| SNX6 | GTF2H3 | 0.712331 | 3 | 0 | 3 |
| SNX6 | WDR89 | 0.703446 | 4 | 0 | 4 |
| SNX6 | TRIT1 | 0.695386 | 4 | 0 | 3 |
| SNX6 | EAPP | 0.695244 | 10 | 0 | 9 |
| SNX6 | STAG1 | 0.692974 | 4 | 0 | 3 |
| SNX6 | TTC27 | 0.68953 | 3 | 0 | 3 |
| SNX6 | KDM5B | 0.687491 | 4 | 0 | 3 |
| SNX6 | FBXO33 | 0.686873 | 5 | 0 | 4 |
| SNX6 | PSMC6 | 0.686637 | 4 | 0 | 3 |
| SNX6 | MCMBP | 0.683871 | 4 | 0 | 3 |
| SNX6 | PARP14 | 0.683323 | 3 | 0 | 3 |
For details and further investigation, click here
