| Full name: eukaryotic translation initiation factor 2 alpha kinase 1 | Alias Symbol: HRI|KIAA1369 | ||
| Type: protein-coding gene | Cytoband: 7p22.1 | ||
| Entrez ID: 27102 | HGNC ID: HGNC:24921 | Ensembl Gene: ENSG00000086232 | OMIM ID: 613635 |
| Drug and gene relationship at DGIdb | |||
EIF2AK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05160 | Hepatitis C | |
| hsa05162 | Measles | |
| hsa05164 | Influenza A | |
| hsa05168 | Herpes simplex infection |
Expression of EIF2AK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF2AK1 | 27102 | 217736_s_at | 0.5935 | 0.0535 | |
| GSE20347 | EIF2AK1 | 27102 | 217736_s_at | 0.5555 | 0.0003 | |
| GSE23400 | EIF2AK1 | 27102 | 217736_s_at | 0.8596 | 0.0000 | |
| GSE26886 | EIF2AK1 | 27102 | 217736_s_at | 0.1084 | 0.6846 | |
| GSE29001 | EIF2AK1 | 27102 | 217736_s_at | 0.5945 | 0.0130 | |
| GSE38129 | EIF2AK1 | 27102 | 217736_s_at | 0.8068 | 0.0000 | |
| GSE45670 | EIF2AK1 | 27102 | 217736_s_at | 0.4329 | 0.0004 | |
| GSE53622 | EIF2AK1 | 27102 | 7112 | 0.7383 | 0.0000 | |
| GSE53624 | EIF2AK1 | 27102 | 7112 | 0.6466 | 0.0000 | |
| GSE63941 | EIF2AK1 | 27102 | 217736_s_at | 1.6171 | 0.0004 | |
| GSE77861 | EIF2AK1 | 27102 | 217736_s_at | 0.5879 | 0.0095 | |
| GSE97050 | EIF2AK1 | 27102 | A_23_P251173 | 0.6657 | 0.1313 | |
| SRP007169 | EIF2AK1 | 27102 | RNAseq | 1.1260 | 0.0138 | |
| SRP008496 | EIF2AK1 | 27102 | RNAseq | 1.2918 | 0.0000 | |
| SRP064894 | EIF2AK1 | 27102 | RNAseq | 0.5889 | 0.0001 | |
| SRP133303 | EIF2AK1 | 27102 | RNAseq | 0.7423 | 0.0000 | |
| SRP159526 | EIF2AK1 | 27102 | RNAseq | 0.6587 | 0.0000 | |
| SRP193095 | EIF2AK1 | 27102 | RNAseq | 0.2153 | 0.0691 | |
| SRP219564 | EIF2AK1 | 27102 | RNAseq | 0.6619 | 0.0656 | |
| TCGA | EIF2AK1 | 27102 | RNAseq | 0.1260 | 0.0025 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by EIF2AK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF2AK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF2AK1 | 27102 | 14 | 1 | 15 | |
| GSE20123 | EIF2AK1 | 27102 | 14 | 1 | 15 | |
| GSE43470 | EIF2AK1 | 27102 | 6 | 1 | 36 | |
| GSE46452 | EIF2AK1 | 27102 | 13 | 1 | 45 | |
| GSE47630 | EIF2AK1 | 27102 | 9 | 1 | 30 | |
| GSE54993 | EIF2AK1 | 27102 | 0 | 6 | 64 | |
| GSE54994 | EIF2AK1 | 27102 | 20 | 1 | 32 | |
| GSE60625 | EIF2AK1 | 27102 | 0 | 0 | 11 | |
| GSE74703 | EIF2AK1 | 27102 | 6 | 0 | 30 | |
| GSE74704 | EIF2AK1 | 27102 | 9 | 0 | 11 | |
| TCGA | EIF2AK1 | 27102 | 55 | 5 | 36 |
Total number of gains: 146; Total number of losses: 17; Total Number of normals: 325.
Somatic mutations of EIF2AK1:
Generating mutation plots.
Highly correlated genes for EIF2AK1:
Showing top 20/1853 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF2AK1 | PMS2 | 0.799924 | 3 | 0 | 3 |
| EIF2AK1 | DTL | 0.74748 | 10 | 0 | 10 |
| EIF2AK1 | DDX56 | 0.746559 | 10 | 0 | 10 |
| EIF2AK1 | UBE2C | 0.742228 | 11 | 0 | 11 |
| EIF2AK1 | PYCR2 | 0.73308 | 3 | 0 | 3 |
| EIF2AK1 | EIF3B | 0.73101 | 12 | 0 | 12 |
| EIF2AK1 | SLC19A1 | 0.729004 | 3 | 0 | 3 |
| EIF2AK1 | CDCA2 | 0.728301 | 5 | 0 | 4 |
| EIF2AK1 | ITPR3 | 0.724684 | 11 | 0 | 10 |
| EIF2AK1 | LSM4 | 0.723026 | 9 | 0 | 9 |
| EIF2AK1 | TPX2 | 0.722192 | 11 | 0 | 10 |
| EIF2AK1 | CCNB2 | 0.718289 | 9 | 0 | 9 |
| EIF2AK1 | MCM5 | 0.718007 | 9 | 0 | 9 |
| EIF2AK1 | ORAI1 | 0.717892 | 6 | 0 | 6 |
| EIF2AK1 | ASPM | 0.716494 | 10 | 0 | 10 |
| EIF2AK1 | MCM2 | 0.716452 | 10 | 0 | 10 |
| EIF2AK1 | LSM5 | 0.713589 | 9 | 0 | 9 |
| EIF2AK1 | NACC1 | 0.713289 | 4 | 0 | 4 |
| EIF2AK1 | DNAJC9 | 0.712503 | 7 | 0 | 7 |
| EIF2AK1 | RPA3 | 0.709527 | 10 | 0 | 10 |
For details and further investigation, click here
