| Full name: solute carrier family 7 member 11 | Alias Symbol: xCT | ||
| Type: protein-coding gene | Cytoband: 4q28.3 | ||
| Entrez ID: 23657 | HGNC ID: HGNC:11059 | Ensembl Gene: ENSG00000151012 | OMIM ID: 607933 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC7A11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC7A11 | 23657 | 209921_at | 1.6356 | 0.4943 | |
| GSE20347 | SLC7A11 | 23657 | 209921_at | 1.9139 | 0.0039 | |
| GSE23400 | SLC7A11 | 23657 | 217678_at | 0.8213 | 0.0001 | |
| GSE26886 | SLC7A11 | 23657 | 209921_at | 1.8532 | 0.0211 | |
| GSE29001 | SLC7A11 | 23657 | 209921_at | 1.1446 | 0.0432 | |
| GSE38129 | SLC7A11 | 23657 | 209921_at | 2.3325 | 0.0000 | |
| GSE45670 | SLC7A11 | 23657 | 209921_at | 2.7195 | 0.0005 | |
| GSE53622 | SLC7A11 | 23657 | 786 | 1.7618 | 0.0000 | |
| GSE53624 | SLC7A11 | 23657 | 786 | 1.9128 | 0.0000 | |
| GSE63941 | SLC7A11 | 23657 | 209921_at | -2.3541 | 0.1225 | |
| GSE77861 | SLC7A11 | 23657 | 209921_at | 2.6906 | 0.0030 | |
| GSE97050 | SLC7A11 | 23657 | A_33_P3242623 | 1.0060 | 0.1729 | |
| SRP007169 | SLC7A11 | 23657 | RNAseq | 4.0353 | 0.0000 | |
| SRP008496 | SLC7A11 | 23657 | RNAseq | 3.9654 | 0.0000 | |
| SRP064894 | SLC7A11 | 23657 | RNAseq | 1.1498 | 0.0270 | |
| SRP133303 | SLC7A11 | 23657 | RNAseq | 1.8438 | 0.0000 | |
| SRP159526 | SLC7A11 | 23657 | RNAseq | 3.5315 | 0.0000 | |
| SRP193095 | SLC7A11 | 23657 | RNAseq | 2.2405 | 0.0000 | |
| SRP219564 | SLC7A11 | 23657 | RNAseq | 1.9576 | 0.1001 | |
| TCGA | SLC7A11 | 23657 | RNAseq | 0.3893 | 0.0621 |
Upregulated datasets: 14; Downregulated datasets: 0.
Survival by SLC7A11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC7A11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC7A11 | 23657 | 0 | 12 | 18 | |
| GSE20123 | SLC7A11 | 23657 | 0 | 12 | 18 | |
| GSE43470 | SLC7A11 | 23657 | 0 | 13 | 30 | |
| GSE46452 | SLC7A11 | 23657 | 1 | 36 | 22 | |
| GSE47630 | SLC7A11 | 23657 | 0 | 22 | 18 | |
| GSE54993 | SLC7A11 | 23657 | 10 | 0 | 60 | |
| GSE54994 | SLC7A11 | 23657 | 2 | 10 | 41 | |
| GSE60625 | SLC7A11 | 23657 | 0 | 1 | 10 | |
| GSE74703 | SLC7A11 | 23657 | 0 | 11 | 25 | |
| GSE74704 | SLC7A11 | 23657 | 0 | 6 | 14 | |
| TCGA | SLC7A11 | 23657 | 10 | 32 | 54 |
Total number of gains: 23; Total number of losses: 155; Total Number of normals: 310.
Somatic mutations of SLC7A11:
Generating mutation plots.
Highly correlated genes for SLC7A11:
Showing top 20/626 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC7A11 | G6PD | 0.747357 | 10 | 0 | 10 |
| SLC7A11 | SRXN1 | 0.713199 | 7 | 0 | 6 |
| SLC7A11 | DLX6-AS1 | 0.701816 | 4 | 0 | 4 |
| SLC7A11 | C16orf74 | 0.695751 | 7 | 0 | 7 |
| SLC7A11 | AKR1C1 | 0.680633 | 12 | 0 | 11 |
| SLC7A11 | FOXE1 | 0.68035 | 10 | 0 | 9 |
| SLC7A11 | TXNRD1 | 0.679799 | 13 | 0 | 11 |
| SLC7A11 | COA6 | 0.67914 | 7 | 0 | 6 |
| SLC7A11 | DKC1 | 0.678752 | 3 | 0 | 3 |
| SLC7A11 | MXRA7 | 0.671177 | 3 | 0 | 3 |
| SLC7A11 | KRTCAP3 | 0.665563 | 4 | 0 | 4 |
| SLC7A11 | ABCC1 | 0.663261 | 12 | 0 | 11 |
| SLC7A11 | AKR1C2 | 0.662605 | 10 | 0 | 10 |
| SLC7A11 | FAM89A | 0.659828 | 3 | 0 | 3 |
| SLC7A11 | TENM2 | 0.65539 | 6 | 0 | 5 |
| SLC7A11 | HAS3 | 0.65037 | 6 | 0 | 5 |
| SLC7A11 | EME1 | 0.649629 | 5 | 0 | 5 |
| SLC7A11 | FEZ1 | 0.645864 | 3 | 0 | 3 |
| SLC7A11 | ATP2B1 | 0.645067 | 11 | 0 | 9 |
| SLC7A11 | PIGW | 0.645021 | 7 | 0 | 6 |
For details and further investigation, click here
