| Full name: syntaxin binding protein 1 | Alias Symbol: hUNC18|MUNC18-1|UNC18|rbSec1 | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 6812 | HGNC ID: HGNC:11444 | Ensembl Gene: ENSG00000136854 | OMIM ID: 602926 |
| Drug and gene relationship at DGIdb | |||
Expression of STXBP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STXBP1 | 6812 | 202260_s_at | 0.2991 | 0.6675 | |
| GSE20347 | STXBP1 | 6812 | 202260_s_at | 0.3301 | 0.2644 | |
| GSE23400 | STXBP1 | 6812 | 202260_s_at | -0.0143 | 0.8883 | |
| GSE26886 | STXBP1 | 6812 | 202260_s_at | 0.3680 | 0.2958 | |
| GSE29001 | STXBP1 | 6812 | 202260_s_at | 0.3976 | 0.4689 | |
| GSE38129 | STXBP1 | 6812 | 202260_s_at | 0.1347 | 0.7183 | |
| GSE45670 | STXBP1 | 6812 | 202260_s_at | -0.1209 | 0.7593 | |
| GSE53622 | STXBP1 | 6812 | 42767 | 0.2307 | 0.0115 | |
| GSE53624 | STXBP1 | 6812 | 42767 | 0.2666 | 0.0103 | |
| GSE63941 | STXBP1 | 6812 | 202260_s_at | -1.1766 | 0.1881 | |
| GSE77861 | STXBP1 | 6812 | 202260_s_at | 0.6088 | 0.2958 | |
| GSE97050 | STXBP1 | 6812 | A_24_P201171 | 0.0874 | 0.7694 | |
| SRP007169 | STXBP1 | 6812 | RNAseq | 0.1379 | 0.8823 | |
| SRP064894 | STXBP1 | 6812 | RNAseq | 0.1570 | 0.4499 | |
| SRP133303 | STXBP1 | 6812 | RNAseq | 0.2777 | 0.2650 | |
| SRP159526 | STXBP1 | 6812 | RNAseq | 0.6059 | 0.1475 | |
| SRP193095 | STXBP1 | 6812 | RNAseq | 0.5902 | 0.0000 | |
| SRP219564 | STXBP1 | 6812 | RNAseq | -0.1373 | 0.7198 | |
| TCGA | STXBP1 | 6812 | RNAseq | -0.0837 | 0.3859 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by STXBP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STXBP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STXBP1 | 6812 | 6 | 9 | 15 | |
| GSE20123 | STXBP1 | 6812 | 6 | 9 | 15 | |
| GSE43470 | STXBP1 | 6812 | 5 | 6 | 32 | |
| GSE46452 | STXBP1 | 6812 | 6 | 13 | 40 | |
| GSE47630 | STXBP1 | 6812 | 4 | 15 | 21 | |
| GSE54993 | STXBP1 | 6812 | 3 | 3 | 64 | |
| GSE54994 | STXBP1 | 6812 | 11 | 8 | 34 | |
| GSE60625 | STXBP1 | 6812 | 0 | 0 | 11 | |
| GSE74703 | STXBP1 | 6812 | 5 | 4 | 27 | |
| GSE74704 | STXBP1 | 6812 | 3 | 7 | 10 | |
| TCGA | STXBP1 | 6812 | 27 | 25 | 44 |
Total number of gains: 76; Total number of losses: 99; Total Number of normals: 313.
Somatic mutations of STXBP1:
Generating mutation plots.
Highly correlated genes for STXBP1:
Showing top 20/362 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STXBP1 | CERCAM | 0.719591 | 3 | 0 | 3 |
| STXBP1 | CDC42EP4 | 0.689433 | 3 | 0 | 3 |
| STXBP1 | PLXNB3 | 0.689144 | 4 | 0 | 4 |
| STXBP1 | ARHGEF11 | 0.683985 | 3 | 0 | 3 |
| STXBP1 | NR2F2 | 0.678217 | 3 | 0 | 3 |
| STXBP1 | TRIB1 | 0.673563 | 3 | 0 | 3 |
| STXBP1 | SSH1 | 0.661985 | 3 | 0 | 3 |
| STXBP1 | STK17A | 0.660958 | 3 | 0 | 3 |
| STXBP1 | EID3 | 0.65864 | 3 | 0 | 3 |
| STXBP1 | NGF | 0.654407 | 4 | 0 | 3 |
| STXBP1 | C20orf194 | 0.653004 | 4 | 0 | 4 |
| STXBP1 | UFM1 | 0.648156 | 4 | 0 | 3 |
| STXBP1 | GFRA3 | 0.644459 | 3 | 0 | 3 |
| STXBP1 | CREB5 | 0.638851 | 4 | 0 | 3 |
| STXBP1 | MTX3 | 0.637871 | 4 | 0 | 4 |
| STXBP1 | CD151 | 0.63764 | 4 | 0 | 4 |
| STXBP1 | ELMO1 | 0.633475 | 4 | 0 | 3 |
| STXBP1 | SMARCD1 | 0.629388 | 3 | 0 | 3 |
| STXBP1 | WTIP | 0.628449 | 3 | 0 | 3 |
| STXBP1 | TIMP4 | 0.627655 | 3 | 0 | 3 |
For details and further investigation, click here
